Recent Advances In Biotechnology Recent Progress In Glycotherapy
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| Author | : Qun Zhou |
| Publisher | : Bentham Science Publishers |
| Total Pages | : 228 |
| Release | : 2016-12-06 |
| Genre | : Science |
| ISBN | : 1681083914 |
Carbohydrates (monosaccharides, oligosaccharides and polysaccharides) exist naturally in free from and as components of other macromolecules (nucleic acids, proteins and lipids). Glycotherapy refers to this use of carbohydrates or glycoengineered macromolecules in fighting life-threatening diseases. Although glycotherapy is a relatively new and limited field of pharmacology, significant progress has been made in recent years in academia and the pharmaceutical industry facilitated by advances in enzymology and recombinant DNA technologies. Consequently, carbohydrate containing biologics are now used in therapeutic regimens. This volume provides a summary of the progress made in developing therapeutic solutions using glycoengineering techniques. Topics covered in this volume include the development of vaccines and antibodies against tumor-associated carbohydrate antigens for cancer treatment, the use of glycan for viral inhibition, glycoPEGylation, hyaluronic acid conjugation, and protein modification and conjugation for increasing therapeutic index using recombinant and chemoenzymatic approaches. The volume is essential reading for biochemists, pharmacologists and R&D professionals interested in glycotherapy.
| Author | : Raj K. Keservani |
| Publisher | : CRC Press |
| Total Pages | : 512 |
| Release | : 2019-08-05 |
| Genre | : Medical |
| ISBN | : 0429877544 |
This new volume, Nanocarriers for Brain Targeting: Principles and Applications, covers recent research on brain physiology and the development of drug delivery systems. It explores a diverse variety of strategies that can be employed to achieve drug targeting to the brain. The nanocarriers that are discussed include nanoparticles, vesicular carriers, carriers having carbon as a core constituent, dispersed systems, and more. The inherent anatomy and physiology of the brain renders it different from other organs. The past few decades have witnessed significant research on brain ailments in response to a majority of hospitalizations that occur due to age-related central nervous system disorders. The prevalence of diverse diseases such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, multiple sclerosis, HIV-dementia, etc., affect about 1.5 billion people globally, which is further anticipated to reach 1.9 billion by the year 2020. Nanocarriers for drug delivery to the brain are seen as one of the answers to this growing problem.
| Author | : National Research Council |
| Publisher | : National Academies Press |
| Total Pages | : 171 |
| Release | : 2012-10-23 |
| Genre | : Science |
| ISBN | : 0309260868 |
A new focus on glycoscience, a field that explores the structures and functions of sugars, promises great advances in areas as diverse as medicine, energy generation, and materials science, this report finds. Glycans-also known as carbohydrates, saccharides, or simply as sugars-play central roles in many biological processes and have properties useful in an array of applications. However, glycans have received little attention from the research community due to a lack of tools to probe their often complex structures and properties. Transforming Glycoscience: A Roadmap for the Future presents a roadmap for transforming glycoscience from a field dominated by specialists to a widely studied and integrated discipline, which could lead to a more complete understanding of glycans and help solve key challenges in diverse fields.
| Author | : |
| Publisher | : Academic Press |
| Total Pages | : 554 |
| Release | : 2019-04-26 |
| Genre | : Science |
| ISBN | : 0128177411 |
Glycans and Glycosaminoglycans as Clinical Biomarkers and Therapeutics - Part B, Volume 163 in the Progress in Molecular Biology and Translational Science series, provides informative monographs on a variety of research topics related to Glycans and glycosaminoglycans as clinical biomarkers and therapeutics. Topics in this update include an Overview of Fugal Glycan-based Therapeutics, Heparin: An Essential Drug for Modern Medicine, Low Molecular Weight Heparins and Their Clinical Applications, The Clinical Use of Fondaparinux: A Synthetic Heparin Pentasaccharid, Heparinoids as Clinically Used Drugs, Marine Glycan-Derived Therapeutics in China, Efficacy of Heparinoid PSS in Treating Cardiovascular and other Diseases—30 Years Clinical Applications in China, and more. - Includes comprehensive coverage of molecular biology - Presents ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided - Contains contributions from renowned experts in the field
| Author | : Uday M. Basheer Al-Naib |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 232 |
| Release | : 2018-09-19 |
| Genre | : Technology & Engineering |
| ISBN | : 1789236525 |
Porous ceramics have recently gained growing importance in industry because of their many applications like filters, absorbers, dust collectors, thermal insulation, hot gas collectors, dielectric resonators, bioreactors, bone replacement and automobile engine components. Generally, porous ceramics have good properties such as mechanical strength, abrasion resistance, and chemical and thermal stability. These porous network ceramic structures also have relatively low density, low mass and low thermal conductivity. Furthermore, permeability is one of the most important properties of porous ceramics for different applications such as membranes because this property directly relates to the pressure drop during filtration. Pore size control is one key factor in fabrication of porous ceramics. The size of particles and their distribution of the raw materials, manufacturing techniques, types of binder used, distribution of binder, and sintering affect the final porosity and pore connectivity, are important things that must be considered during the manufacturing of a porous ceramic body. Therefore, the development of porous ceramic research requires sufficient mechanical and chemical stability as well as permeability. This book covers a wide range of topics such as porous ceramic structure and properties, preparation, simulation and fabrication, sintering, applications for bioceramics, sensors, magnetics and energy saving.
| Author | : Iwona Cieślak |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2022 |
| Genre | : |
| ISBN | : 9783036530222 |
This book is dedicated to urbanization, which is observed every day, as well as the methods and techniques of monitoring and analyzing this phenomenon. In the 21st century, urbanization has gained momentum, and the awareness of the significance and influence of this phenomenon on our lives make us take a closer look at it not only with curiosity, but also great attention. There are numerous reasons for this, among which the economy is of special significance, but it also has many results, namely, economic, social, and environmental. First of all, it is a spatial phenomenon, as all of the aspects can be placed in space. We would therefore like to draw special attention to the results of urbanization seen on the Earth's surface and in the surrounding space. The urbanization-land relation seems obvious, but is also interesting and multi-layered. The development of science and technology provides a lot of new tools for observing urbanization, as well as the analyses and inference of the phenomenon in space. This book is devoted to in-depth analysis of past, present and future urbanization processes all over the world. We present the latest trends of research that use experience in the widely understood geography of the area. This book is focused on multidisciplinary phenomenon, i.e., urbanization, with the use of the satellite and photogrammetric observation technologies and GIS analyses.
| Author | : Wei Wang |
| Publisher | : Frontiers Media SA |
| Total Pages | : 147 |
| Release | : 2023-11-01 |
| Genre | : Medical |
| ISBN | : 2832538193 |
| Author | : René Roy |
| Publisher | : ACS Symposium |
| Total Pages | : 0 |
| Release | : 2008 |
| Genre | : Science |
| ISBN | : 9780841239838 |
This book is the first of its kind entirely dedicated to carbohydrate vaccines written by renowned scientists with expertise in carbohydrate chemistry and immunochemistry. It covers the synthesis of carbohydrate antigens related to bacteria and parasites such as: Heamophilus influenza, Streptococcus pnemoniae, Shigella flexneri, Candida albicans, Mycobacterium tuberculosis, and Chlamydia. The first three chapters are of wide interest as they cover fundamental concerns in new vaccine developments. The first one presents the immune system and how carbohydrate antigens are processed before protective antibodies are produced. It also illustrates antigen presentation in the context of major histocompatibility complexes (MHCs). The second chapter describes regulatory issues when carbohydrate vaccines are involved while the third one discuss several techniques used in conjugation chemistry and the implication of certain chemical linkages that may induce unexpected anti-linker antibodies. This section will be particularly appealing for those involved in drug-conjugate design, pro-drug developments, and drug vectorization. The book concludes with one chapter that illustrates the principle through which peptide antigens can functionally mimic carbohydrate epitopes, thus, unraveling the potential for peptide surrogates as replacement for complex carbohydrate structures. This book is unique in that it covers all aspects related to carbohydrate vaccines including the success story with the first semi-synthetic bacterial polysaccharide vaccine against Heamophilus influenza type b responsible for pneumonia and meningitis, liable for more than 600,000 infant deaths worldwide in developing countries. The book also presents regulatory issues and will thus be vital for government agencies approving candidate vaccines. It widely covers synthetic methodologies for the attachment of carbohydrate antigens to peptides and immunogenic protein carriers. Vaccines against bacterial antigens, cancer, and parasites are also discussed by worldwide experts in this field in details. No other book contains such a wide panel of different expertise. It will also be useful to students and researchers involved with the immunology of forreings antigens and how the under appreciated carbohydrate antigens are processed by the immune system.
| Author | : Tanveer Ali Dar |
| Publisher | : Academic Press |
| Total Pages | : 0 |
| Release | : 2019-05-21 |
| Genre | : Science |
| ISBN | : 9780128119136 |
Protein Modificomics: From Modifications to Clinical Perspectives comprehensively deals with all of the most recent aspects of post-translational modification (PTM) of proteins, including discussions on diseases involving PTMs, such as Alzheimer's, Huntington's, X-linked spinal muscular atrophy-2, aneurysmal bone cyst, angelman syndrome and OFC10. The book also discusses the role PTMs play in plant physiology and the production of medicinally important primary and secondary metabolites. The understanding of PTMs in plants helps us enhance the production of these metabolites without greatly altering the genome, providing robust eukaryotic systems for the production and isolation of desired products without considerable downstream and isolation processes.
| Author | : Sabu Thomas |
| Publisher | : Woodhead Publishing |
| Total Pages | : 354 |
| Release | : 2018-03-20 |
| Genre | : Technology & Engineering |
| ISBN | : 008102195X |
Fundamental Biomaterials: Polymers provides current information on findings and developments of biopolymers and their conversion from base materials to medical devices. Chapters analyze the types of polymers and discuss a range of biomedical applications. It is the first title in a three volume set, with each reviewing the most important and commonly used classes of biomaterials and providing comprehensive information on classification, materials properties, behavior, biocompatibility and applications. The book concludes with essential information on wear, lifetime prediction and cytotoxicity of biomaterials. This title will be of use to researchers and professionals in development stages, but will also help medical researchers understand and effectively communicate the requirements of a biomaterial for a specific application. Further, with the recent introduction of a number of interdisciplinary bio-related undergraduate and graduate programs, this book will be an appropriate reference volume for large number of students at undergraduate and post graduate levels. - Provides current information on findings and developments of biopolymers and their conversion from base materials to medical devices - Includes analyses of the types of polymers and a discussion of a range of biomedical applications - Presents essential information on wear, lifetime prediction and cytotoxicity of biomaterials - Explores both theoretical and practical aspects of polymers in biomaterials
