Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries

Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries
Author: Peter H. Seeberger
Publisher: John Wiley & Sons
Total Pages: 321
Release: 2004-04-07
Genre: Science
ISBN: 0471460729

Solid-phase synthesis of carbohydrates presents unique challenges to synthetic chemists and currently represents one of the hottest areas of research in bioorganic chemistry. Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries addresses the exciting expectation that solid-phase assembly of oligosaccharides will have a fundamental impact on the field of glycobiology. This publication details the methodologies currently investigated for the attachment of carbohydrates to beads, synthesis including coupling strategies, and removal of the product from beads. With chapters written by eminent contributing authors, the material explores different synthetic strategies, glycosylation protocols, the use of solid supports versus soluble polymeric supports, and "on-resin" analytical methods. Tremendous progress in the field has set the stage for Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries to provide a wealth of information on such topics as: Specific oligosaccharide structures used in signal transduction processes Preparation and screening of glycopeptide libraries Solid-phase carbohydrate synthesis

Modern Methods in Carbohydrate Synthesis

Modern Methods in Carbohydrate Synthesis
Author: Shaheer H. Khan
Publisher: CRC Press
Total Pages: 580
Release: 2020-08-26
Genre: Science
ISBN: 1000159485

Modern Methods in Carbohydrate Synthesis presents in one volume a sequence of chapters leading from classical methods through to today's newest state-of -the-art technology for oligosaccharide synthesis. It places particular emphasis on the most recent breakthroughs in the field, including emerging technologies for both oligosaccharide and glycoconjugate synthesis. Chapters describing the synthesis of increasingly important glycosidic linkage analogs, as well as the oligosaccharides containing derivatives and analogs of natural sugars are included. While chemical-synthetic methods constitute the major part of the book, completing the volume is a section on the rapidly expanding and important field of enzymatic synthesis, also covering combined chemical and enzymatic synthesis. Chapters are written by leading experts in the field. Wherever possible, methods of synthesis are provided in sufficient detail to allow the reader to implement the techniques described. More than 1700 references are provided in the 21 chapters comprising the book. This volume should provide a wealth of information to a large number of synthetic organic chemists, medicinal chemists, protein chemists, biochemists, glycobiologists and cell biologists, including students in these fields.

Automated Synthesis of the Lewis Blood Group Oligosaccharides

Automated Synthesis of the Lewis Blood Group Oligosaccharides
Author: Kerry Routenberg Love
Publisher:
Total Pages: 323
Release: 2004
Genre:
ISBN:

Cell-surface carbohydrates are markers of specific cell types. These oligosaccharides are involved in recognition, adhesion, and signal transduction events. Advances in molecular glycobiology rely heavily on straightforward access to structurally defined oligosaccharides, but traditional syntheses of complex carbohydrates have been very laborious. Development of a novel linker and monitoring of each glycosylation reaction during automated solid-phase oligosaccharide synthesis allowed for the rapid synthesis of three Lewis-type cell surface oligosaccharides. The assembly of the nonasaccharide adenocarcinoma marker Le[superscript]y-Le[superscript]x monosaccharide building blocks was achieved in just 23 hours, while the syntheses of the tumor markers Lewis X, a pentasaccharide, and Lewis Y, a hexasaccharide, required only 12 and 14 hours respectively. The automation of carbohydrate synthesis greatly accelerates access to molecules for biological study and vaccine development.

Reactivity Tuning in Oligosaccharide Assembly

Reactivity Tuning in Oligosaccharide Assembly
Author: Bert Fraser-Reid
Publisher: Springer Science & Business Media
Total Pages: 309
Release: 2011-05-12
Genre: Science
ISBN: 3642209130

Armed–Disarmed Effects in Carbohydrate Chemistry: History, Synthetic and Mechanistic Studies, by Bert Fraser-Reid and J. Cristóbal López * A Survey of Ley’s Reactivity Tuning in Oligosaccharide Synthesis, by Ana M. Gómez * “Active–Latent” Thioglycosyl Donors and Acceptors in Oligosaccharide Syntheses, by Tze Chieh Shiao and René Roy * Effect of Electron-Withdrawing Protecting Groups at Remote Positions of Donors on Glycosylation Stereochemistry, by Kwan Soo Kim and Dae-Hwan Suk * Influence of Protecting Groups on the Reactivity and Selectivity of Glycosylation: Chemistry of the 4,6-O-Benzylidene Protected Mannopyranosyl Donors and Related Species, by Sylvain Aubry, Kaname Sasaki, Indrajeet Sharma and David Crich * Superarmed and Superdisarmed Building Blocks in Expeditious Oligosaccharide Synthesis, by Hemali D. Premathilake and Alexei V. Demchenko * Programmable One-Pot Glycosylation, by Chung -Yi Wu and Chi -Huey Wong * Uronic Acids in Oligosaccharide and Glycoconjugate Synthesis, by Jeroen D. C. Codée, Alphert E. Christina, Marthe T. C. Walvoort, Herman S. Overkleeft and Gijsbert A. van der Marel

Essentials of Glycobiology

Essentials of Glycobiology
Author: Ajit Varki
Publisher: CSHL Press
Total Pages: 694
Release: 1999
Genre: Medical
ISBN: 9780879696818

Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.

Glycochemical Synthesis

Glycochemical Synthesis
Author: Shang-Cheng Hung
Publisher: John Wiley & Sons
Total Pages: 574
Release: 2016-10-10
Genre: Science
ISBN: 1118299841

This book is a comprehensive and concise review on principles, strategies, and crucial advances in glycochemistry. It focuses on synthesis and practical applications and emphasizes state-of-the-art approaches to the assembly and design of sugars. • Provides detailed discussion on specific topics like oligosaccharide assembly and design of sugars, techniques in glycoconjugate preparation, multivalency, and carbohydrate-based drug design • Uses notable examples, like solution-based one-pot methods and automated methods for sugar assembly, to illustrate important concepts and advances in a rapidly emerging field • Discusses practical applications of carbohydrates, like medicine, therapeutics, drug and vaccine development

Carbohydrates: The Essential Molecules of Life

Carbohydrates: The Essential Molecules of Life
Author: Robert V. Stick
Publisher: Elsevier
Total Pages: 497
Release: 2010-08-06
Genre: Technology & Engineering
ISBN: 0080927025

This book provides the "nuts and bolts" background for a successful study of carbohydrates - the essential molecules that not only give you energy, but are an integral part of many biological processes.A question often asked is 'Why do carbohydrate chemistry?' The answer is simple: It is fundamental to a study of biology. Carbohydrates are the building blocks of life and enable biological processes to take place.Therefore the book will provide a taste for the subject of glycobiology.Covering the basics of carbohydrates and then the chemistry and reactions of carbohydrates this book will enable a chemist to gain essential knowledge that will enable them to move smoothly into the worlds of biochemistry, molecular biology and cell biology. Includes perspective from new co-author Spencer Williams, who enhances coverage of the connection between carbohydrates and life Describes the basic chemistry and biology of carbohydrates Reviews the concepts, synthesis, reactions, and biology of carbohydrates

Bacterial Lipopolysaccharides

Bacterial Lipopolysaccharides
Author: Yuriy A. Knirel
Publisher: Springer Science & Business Media
Total Pages: 444
Release: 2011-07-13
Genre: Science
ISBN: 3709107334

The bacterial lipopolysaccharide also known as endotoxin is exhaustively covered in the present work. Central emphasis is placed upon the fine chemical structure of the lipopolysaccharide and its significance for understanding their activity and function. In particular, the role it plays in the interaction of bacteria with other biological systems is examined. New aspects of their physicochemical biology are introduced and updates to the current knowledge concerning the lipopolysaccharide are provided. This important class of biomolecules has recently attracted the attention of many investigators, in particular for understanding its involvement in innate immunity, toll-like receptor recognition and intracellular signaling.