Quick Guide To The Cytochrome P450 System
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Author | : Paul R. Ortiz de Montellano |
Publisher | : Springer Science & Business Media |
Total Pages | : 702 |
Release | : 2007-02-05 |
Genre | : Medical |
ISBN | : 0387274472 |
Cytochrome P450: Structure, Mechanism, and Biochemistry, third edition is a revision of a review that summarizes the current state of research in the field of drug metabolism. The emphasis is on structure, mechanism, biochemistry, and regulation. Coverage is interdisciplinary, ranging from bioinorganic chemistry of cytochrome P450 to its relevance in human medicine. Each chapter provides an in-depth review of a given topic, but concentrates on advances of the last 10 years.
Author | : Michael D. Coleman |
Publisher | : John Wiley & Sons |
Total Pages | : 360 |
Release | : 2010-03-30 |
Genre | : Science |
ISBN | : 9780470689349 |
Human Drug Metabolism, An Introduction, Second Edition provides an accessible introduction to the subject and will be particularly invaluable to those who already have some understanding of the life sciences. Completely revised and updated throughout, the new edition focuses only on essential chemical detail and includes patient case histories to illustrate the clinical consequences of changes in drug metabolism and its impact on patient welfare. After underlining the relationship between efficacy, toxicity and drug concentration, the book then considers how metabolizing systems operate and how they impact upon drug concentration, both under drug pressure and during inhibition. Factors affecting drug metabolism, such as genetic polymorphisms, age and diet are discussed and how metabolism can lead to toxicity is explained. The book concludes with the role of drug metabolism in the commercial development of therapeutic agents as well as the pharmacology of some illicit drugs.
Author | : Kelly L. Cozza |
Publisher | : American Psychiatric Publishing |
Total Pages | : 294 |
Release | : 2001 |
Genre | : Medical |
ISBN | : |
Adverse medication reactions account for up to 7,000 deaths annually in the United States. In today's era of polypharmacy, busy clinicians - especially those who practice in medical/surgical settings - must be able to quickly find and even anticipate psychiatric drug interactions.
Author | : Pavel Anzenbacher |
Publisher | : John Wiley & Sons |
Total Pages | : 755 |
Release | : 2012-05-29 |
Genre | : Medical |
ISBN | : 352732903X |
A practice-oriented desktop reference for medical professionals, toxicologists and pharmaceutical researchers, this handbook provides systematic coverage of the metabolic pathways of all major classes of xenobiotics in the human body. The first part comprehensively reviews the main enzyme systems involved in biotransformation and how they are orchestrated in the body, while parts two to four cover the three main classes of xenobiotics: drugs, natural products, environmental pollutants. The part on drugs includes more than 300 substances from five major therapeutic groups (central nervous system, cardiovascular system, cancer, infection, and pain) as well as most drugs of abuse including nicotine, alcohol and "designer" drugs. Selected, well-documented case studies from the most important xenobiotics classes illustrate general principles of metabolism, making this equally useful for teaching courses on pharmacology, drug metabolism or molecular toxicology. Of particular interest, and unique to this volume is the inclusion of a wide range of additional xenobiotic compounds, including food supplements, herbal preparations, and agrochemicals.
Author | : S. Cyrus Khojasteh |
Publisher | : Springer Nature |
Total Pages | : 241 |
Release | : 2022-12-12 |
Genre | : Medical |
ISBN | : 3031106911 |
This book is intended for a broad readership, in particular, those working or interested in drug discovery coming from various disciplines such as medicinal chemistry, pharmacology, drug metabolism and pharmacokinetics, bioanalysis, clinical sciences, biochemistry, pharmaceutics, and toxicology. It provides, for the first time, a completely integrated look at multiple aspects of ADME sciences (absorption, distribution, metabolism, and excretion) in a summary format that is clear, concise, and self-explanatory. DMPK in Drug Discovery - Guide to Data Interpretation and integration leverages the prior knowledge from the first book that covers the basics of each concept (Drug Metabolism and Pharmacokinetics Quick Guide). This reference book is meant to be used day to day and provides many useful tables (used for data interpretation), figures, and case studies that can facilitate drug discovery. The case studies are intended to be short and relevant to the topic discussed and present another dimension to the discussions.
Author | : Patrick Schnider |
Publisher | : Royal Society of Chemistry |
Total Pages | : 541 |
Release | : 2021-08-27 |
Genre | : Science |
ISBN | : 1788012275 |
Medicinal chemistry is a complex science that lies at the very heart of drug discovery. Poor solubility, complex metabolism, tissue retention and slow elimination are just some of the properties of investigational compounds that present a challenge to the design and conduct of ADMET studies. Medicinal chemistry experience and knowledge relating to how a lead structure was modified to solve a specific problem is generally very challenging to retrieve. Presented in a visual and accessible style, this book provides rapid solutions to overcome the universal challenges to optimizing ADMET.
Author | : Catherine Pelletier |
Publisher | : McGraw-Hill Education / Medical |
Total Pages | : 0 |
Release | : 2003-03-17 |
Genre | : Medical |
ISBN | : 9780071388788 |
Organized by drug group, this book presents a complete review of pharmacology in an innovative format. Composed entirely of tables and diagrams, this book facilitates comparison and clarifies relationships among drugs in terms of interactions, pharmacokinetics, uses, and side effects. Each chapter begins with an outline of the drug class discussed, followed by a list of key terms.
Author | : Richard Balon, M.D. |
Publisher | : American Psychiatric Pub |
Total Pages | : 238 |
Release | : 2023-03-30 |
Genre | : Medical |
ISBN | : 1615374531 |
Author | : Mea A. Weinberg |
Publisher | : John Wiley & Sons |
Total Pages | : 378 |
Release | : 2015-04-15 |
Genre | : Medical |
ISBN | : 1118953096 |
With increasing numbers of dental patients being elderly or having medical conditions, it is important for the dentist to understand how these conditions may impact dental treatment. The Dentist’s Quick Guide to Medical Conditions presents the relevant information dentists need—symptoms, diagnostic tests, medications prescribed, and dental management—for each disease and condition. Chapters will focus on each major bodily system, including respiratory, cardiovascular, hematologic, endocrine, gastrointestinal, immune, nervous, reproductive, and urinary, as well as chapters on the liver, kidneys, skin, and psychological conditions. Appendices list guidelines for antibiotic prophylaxis, additional conditions requiring antibiotics, and a quick list of diagnostic tests.
Author | : Gary H. Wynn |
Publisher | : American Psychiatric Pub |
Total Pages | : 608 |
Release | : 2009-06-03 |
Genre | : Medical |
ISBN | : 1585628921 |
Drug interactions have become a significant iatrogenic complication, with as many as 5% of hospitalizations and 7,000 deaths annually attributable to drug-drug interactions in the United States. There are several reasons these numbers have increased. First, many new medications have been brought to market in recent years. Second, advances in medical care have resulted in increased longevity and more elderly patients than ever before -- patients who are more likely to be following polypharmacy regimens. Population patterns in the U.S. have amplified this trend, with aging baby boomers swelling the patient pool and demanding treatment with medications advertised on television and in print. Fortunately, drug interactions can be prevented with access to current, comprehensive, reliable information, and the Clinical Manual of Drug Interaction Principles for Medical Practice provides just that in a user-friendly format psychiatry clinicians (including residents and nurses) and forensics experts will find indispensable. With this new edition, the book has evolved from "Concise Guide" to "Clinical Manual" and offers the expanded coverage and features healthcare providers need to keep up with this critical field. The book is well organized, with major sections on metabolism; cytochrome P450 enzymes; drug interactions by medical specialty; and practical matters, such as the medicolegal implications of drug-drug interactions and how to retrieve and review the literature. In the section on P450 enzymes, each chapter addresses what the individual enzyme does and where, its polymorphisms, and drugs that inhibit or induce activity. Each chapter also includes extensive references and study cases to help the reader understand and contextualize the information. A number of additional features enhance the book's scope and utility: The book boasts the very latest information in the area of drug metabolism, transport, and interaction. The chapter on P-glycoprotein (a drug transporter) was expanded from the last edition to include a broader array of transport mechanisms. The highest ethical standard was adhered to in the development of this volume, which was not supported in any way by pharmaceutical makers or distributors. All eight contributors to this excellent resource are experts in the fields they have addressed, and clinicians can trust that the information contained in the Manual reflects the very latest research. This exceptionally practical manual is essential to maintaining the highest standard of care.