Sickle Cell Disease (SCD) is a complex and multifaceted condition, not only in terms of its physical symptoms but also in the psychological and emotional toll it can take on those affected. Throughout my career and experiences with individuals navigating this illness, I have come to understand the profound impact that mental health has on managing chronic disease. This book, Psychological Support by Cognitive Behavioral Therapy for Sickle Cell Disease, is born from the desire to bridge the gap between medical treatment and psychological support for individuals living with SCD. Cognitive Behavioral Therapy (CBT) has long been recognized as an effective tool in managing psychological distress, particularly in chronic illness settings. By addressing the thoughts, feelings, and behaviors that arise from the experience of illness, CBT helps individuals reclaim a sense of control and empowerment in their daily lives. For those with Sickle Cell Disease, who often experience unpredictable episodes of pain, fatigue, and other physical symptoms, having a reliable psychological framework for managing these challenges is crucial. This book is designed to provide a comprehensive, accessible guide for individuals, caregivers, and mental health professionals. We explore the biological basis of SCD, alongside the genetic and hereditary aspects, to provide a solid understanding of the disease. But we also go beyond biology—delving into how trauma, mental health, and cognitive processes influence the overall experience of SCD. The tools of CBT are presented in a structured way, offering readers practical techniques to manage both the psychological and physical burdens of the disease. Additionally, we delve into various cognitive behavioral strategies that can be tailored to each individual’s needs, whether through personalized therapeutic approaches, pain management, or navigating the complexities of living with a genetic illness. The book also addresses specific challenges such as societal pressures, navigating medical bureaucracy, and the emotional impact on family dynamics. Ultimately, this book aims to provide hope and resilience, not only through scientific knowledge but also through practical strategies that foster mental and emotional strength. My hope is that, through the tools and approaches outlined here, individuals with Sickle Cell Disease will find support in their journey toward well-being.