Proteomics And Nanocrystallography
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Author | : Eugenia Pechkova |
Publisher | : Springer Science & Business Media |
Total Pages | : 199 |
Release | : 2012-12-06 |
Genre | : Science |
ISBN | : 1461500419 |
The book addresses the most recent developments in structural and functional proteomics underlying the recent contributions given in these areas by our laboratory to the instrumentations, the methods and the procedures as mutuated from the nanoscale sciences and technologies. These developments introduced in the last few years make now possible protein massive identification (mass spectrometry and biomolecular arrays down to nanoamounts) and protein structural characterization in solution and in crystals down to the atomic scale to an extent and to a degree so far unmatched. Emphasis is placed in the growth by nanobiofilm template of protein crystals of any type and size from millimeter to micron, leading in combination with microfocus synchrotron technology and atomic force microscopy to the definition of a new field called nanocrystallography. The few useful examples being shown, concerning yet structurally unsolved proteins, point this very promising approach nanotechnology-based in structural proteomics using highly focused X-rays. This has not to be confused with the important study of nanocrystals, both organic and inorganic, and novel diamond like nanocomposite materials and devices having 3D protein crystals as matrices to be equilibrated with nanoparticles/gold/silver to be utilized in the most diversified electronic applications here also summarized. vii Acknowledgments We are particularly grateful to Giuseppe Zanotti at the University of Padova for his fundamental collaboration during all the crystallographic studies.
Author | : Eugenia Pechkova |
Publisher | : |
Total Pages | : 208 |
Release | : 2003-09-01 |
Genre | : |
ISBN | : 9781461500421 |
Author | : Eaton E. Lattman |
Publisher | : JHU Press |
Total Pages | : 149 |
Release | : 2008-04-28 |
Genre | : Medical |
ISBN | : 0801888085 |
The proteome remains a mysterious realm. Researchers have determined the structures of only a small fraction of the proteins encoded by the human genome. Crystallography continues to be the primary method used to determine the structures of the remaining unknown proteins. This imaging technique uses the diffraction of X-rays to determine a protein’s three-dimensional molecular structure. Drawing on years of research and teaching experience, Eaton E. Lattman and Patrick J. Loll use clear examples and abundant illustrations to provide a concise and accessible primer on protein crystallography. Discussing the basics of diffraction, the behavior of two- and three-dimensional crystals, phase determination (including MIR and MAD phasing and molecular replacement), the Patterson function, and refinement, Lattman and Loll provide a complete overview of this important technique, illuminated by physical insights. The crisp writing style and simple illustrations will provide beginner crystallographers with a guide to the process of unraveling protein structure.
Author | : Eugenia Pechkova |
Publisher | : CRC Press |
Total Pages | : 514 |
Release | : 2011-11-11 |
Genre | : Medical |
ISBN | : 9814267937 |
This book presents an overview of the current state of research in both synchrotron radiation and structural proteomics from different laboratories worldwide. The book presents recent research results in the most advanced methods of synchrotron radiation analysis, protein micro- and nano crystallography, X-ray scattering and X-ray optics, coherent
Author | : Roger L. Lundblad |
Publisher | : CRC Press |
Total Pages | : 260 |
Release | : 2005-10-14 |
Genre | : Medical |
ISBN | : 1000654044 |
Largely driven by major improvements in the analytical capability of mass spectrometry, proteomics is being applied to broader areas of experimental biology, ranging from oncology research to plant biology to environmental health. However, while it has already eclipsed solution protein chemistry as a discipline, it is still essentially an extension
Author | : |
Publisher | : Academic Press |
Total Pages | : 377 |
Release | : 2014-07-03 |
Genre | : Business & Economics |
ISBN | : 0128005955 |
Volume 95 of Advances in Protein Chemistry and Structural Biology focuses on advances in proteomic techniques and their application in biomedicine and pharmacology. This volume describes in detail the applications of these techniques in studying a number of diseases and specific protein modifications and profiles, including phosphoproteomics, glycoproteomics, and more. Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology series is the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics. Describes advances in application of powerful techniques in translational research (biomedicine and pharmacology) Chapters are written by authorities in their field Targeted to a wide audience of researchers, specialists, and students The information provided in the volume is well supported by a number of high quality illustrations, figures, and tables
Author | : Claudio Nicolini |
Publisher | : CRC Press |
Total Pages | : 367 |
Release | : 2019-10-10 |
Genre | : Medical |
ISBN | : 9814241393 |
This volume introduces, in a coherent and comprehensive fashion, the Pan Stanford Series on Nanobiotechnology by defining and reviewing the major sectors of nanobiotechnology and nanobiosciences with respect to the most recent developments. It covers the basic principles and main applications of nanobiotechnology as an emerging field at the frontiers of biotechnology and nanotechnology, with contributions from leading scientists active in their respective specialties.
Author | : Roger L. Lundblad |
Publisher | : CRC Press |
Total Pages | : 446 |
Release | : 2009-05-12 |
Genre | : Medical |
ISBN | : 1420073427 |
Reflecting the versatility of the author's science and the depth of his experience, Application of Solution Protein Chemistry to Biotechnology explores key contributions that protein scientists can make in the development of products that are both important and commercially viable, and provides them with tools and information required for successfu
Author | : Jan Drenth |
Publisher | : Springer Science & Business Media |
Total Pages | : 332 |
Release | : 2007-04-05 |
Genre | : Science |
ISBN | : 0387337466 |
X-ray crystallography is an established method for studying the structure of proteins and other macromolecules. As the importance of proteins grows, researchers in many fields have found that a working knowledge of X-ray diffraction is an indispensable tool. In this new edition of his essential work, the internationally recognized researcher Dr. Jan Drenth offers an up-to-date and technically rigorous introduction to the subject, providing the theoretical background necessary to understand how the structure of proteins is determined at atomic resolution. New material in the 3rd edition includes a section on twinning, an additional chapter on crystal growth and a discussion of single-wavelength anomalous dispersion.
Author | : Dennis Sherwood |
Publisher | : Oxford University Press |
Total Pages | : 640 |
Release | : 2011 |
Genre | : Language Arts & Disciplines |
ISBN | : 019955904X |
Information derived from X-ray crystal structures of biological molecules allows us to explain their functions in living organisms in extraordinary detail, and to develop drugs to treat disease. This book describes the principles and practice of X-ray diffraction as a key technique at the forefront of new discoveries in biology and medicine.