Promotion of Neuronal Survival and Axonal Regeneration in Clarke's Nucleus After Spinal Cord Injury in Adult Rats
Author | : Leung-wah Yick |
Publisher | : |
Total Pages | : 272 |
Release | : 1999 |
Genre | : Central nervous system |
ISBN | : |
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Author | : Leung-wah Yick |
Publisher | : |
Total Pages | : 272 |
Release | : 1999 |
Genre | : Central nervous system |
ISBN | : |
Author | : 易亮華 |
Publisher | : Open Dissertation Press |
Total Pages | : 198 |
Release | : 2017-01-27 |
Genre | : Medical |
ISBN | : 9781374779143 |
This dissertation, "Promotion of Neuronal Survival and Axonal Regeneration in Clarke's Nucleus After Spinal Cord Injury in Adult Rats" by 易亮華, Leung-wah, Yick, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. DOI: 10.5353/th_b3123965 Subjects: Neurons - Growth Central nervous system - Regeneration Spinal cord - Wounds and injuries Rats - Physiology
Author | : Robert Vink |
Publisher | : University of Adelaide Press |
Total Pages | : 354 |
Release | : 2011 |
Genre | : Medical |
ISBN | : 0987073052 |
The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.
Author | : A.M. Davies |
Publisher | : Elsevier Inc. Chapters |
Total Pages | : 28 |
Release | : 2013-05-06 |
Genre | : Medical |
ISBN | : 0128062215 |
Author | : George J. Siegel |
Publisher | : Lippincott Raven |
Total Pages | : 1216 |
Release | : 1999 |
Genre | : Medical |
ISBN | : |
Illustrations by Lorie M. Gavulic, MFA Sponsored by the American Society for Neurochemistry.
Author | : William M. Reichert |
Publisher | : CRC Press |
Total Pages | : 300 |
Release | : 2007-12-17 |
Genre | : Medical |
ISBN | : 1420009303 |
Despite enormous advances made in the development of external effector prosthetics over the last quarter century, significant questions remain, especially those concerning signal degradation that occurs with chronically implanted neuroelectrodes. Offering contributions from pioneering researchers in neuroprosthetics and tissue repair, Indwel
Author | : National Research Council |
Publisher | : National Academies Press |
Total Pages | : 610 |
Release | : 2000-11-13 |
Genre | : Social Science |
ISBN | : 0309069882 |
How we raise young children is one of today's most highly personalized and sharply politicized issues, in part because each of us can claim some level of "expertise." The debate has intensified as discoveries about our development-in the womb and in the first months and years-have reached the popular media. How can we use our burgeoning knowledge to assure the well-being of all young children, for their own sake as well as for the sake of our nation? Drawing from new findings, this book presents important conclusions about nature-versus-nurture, the impact of being born into a working family, the effect of politics on programs for children, the costs and benefits of intervention, and other issues. The committee issues a series of challenges to decision makers regarding the quality of child care, issues of racial and ethnic diversity, the integration of children's cognitive and emotional development, and more. Authoritative yet accessible, From Neurons to Neighborhoods presents the evidence about "brain wiring" and how kids learn to speak, think, and regulate their behavior. It examines the effect of the climate-family, child care, community-within which the child grows.
Author | : Daniel Laskowitz |
Publisher | : CRC Press |
Total Pages | : 388 |
Release | : 2016-04-21 |
Genre | : Medical |
ISBN | : 1498766579 |
Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the developme
Author | : Somasish Ghosh Dastidar |
Publisher | : |
Total Pages | : 344 |
Release | : 2011 |
Genre | : Cells |
ISBN | : |
The generation of neurons in the mammalian brain involves a highly complex but carefully choreographed sequence of events including the regulated proliferation of neural progenitor cells, their carefully-timed differentiation into neurons, the migration of newly produced neurons to predictable destinations in the brain, the extension of axons that connect to target cells sometimes located at a considerable distance away and the life-long maintenance of survival of mature neurons that have made proper connections. Numerous molecules have been identified that are involved in the control of these processes. Among these, TLE1, FoxG1, and MeCP2 play critical roles on early brain development. Whereas TLE1 and FoxG1 ensure that neural progenitor cells continue to proliferate until proper brain mass is built, MeCP2 has been implicated in the regulation of various developmental process including survival of neural progenitor cells, axon guidance and morphogenesis of certain brain parts. However, all three of these molecules are abundantly expressed in neurons of the postnatal brain and into adulthood. Their roles in postmitotic neurons are poorly understood. The research I have done as part of my thesis and described herein has shed light on this important issue. I have discovered that FoxG1 and TLE1 cooperate to maintain the survival of postmitotic neurons. In contrast, one of the two isoforms of MeCP2 promotes neuronal death. I discovered that FoxG1 inhibits this cell death-promoting activity of MeCP2. I believe my research provides new information on how the survival of neurons is maintained normally. It is possible that deregulation of these molecules contributes to the abnormal loss of neurons in neurodegenerative diseases as well as to dysfunction of neurons in other brain disorders. Indeed mutations of MeCP2 and FoxG1 cause Rett syndrome, a debilitating neurodevelopmental disorder. The dissertation is organized into four chapters. Chapter 1 provides an introduction of TLE1, FoxG1 and MeCP2 whereas the other three chapters describe my research on each of the three molecules and the interrelationships between them.