Cybersecurity is a paramount concern in both Internet of Things (IoT) and Cyber-Physical Systems (CPSs) due to the interconnected and often critical nature of these systems. The integration of AI/ML into the realm of IoT and CPS security has gained significant attention and momentum in recent years. The success of AI/ML in various domains has sparked interest in leveraging these technologies to enhance the security, resilience, and adaptability of IoT and CPS. Secure and Smart Cyber-Physical Systems provides an extensive exploration of AI/ML-based security applications in the context of IoT and CPS. Features Presents cutting-edge topics and research in IoT and CPS Includes contributions from leading worldwide researchers Focuses on CPS architectures for secure and smart environments Explores AI/ML and blockchain approaches for providing security and privacy to CPS including smart grids, smart cities, and smart healthcare Provides comprehensive guidance into the intricate world of software development for medical devices Covers a blueprint for the emergence of 6G communications technology in Industry 5.0 and federated-learning-based secure financial services This book covers state-of-the-art problems, existing solutions, and potential research directions for CPS researchers, scholars, and professionals in both industry and academia.