This book is the proceedings of the 4th International Conference on Advances in Computational Science and Engineering (ICACSE 2023, December 16–17, 2023, Manila, Philippines) and contains the selected peer-reviewed papers which reflect recent achievements in the field of application of the computational methods and algorithms in scientific research and engineering design. The papers presented covered topics such as advances in system integration, high-performance computing, modeling, and simulation, big data analytics, big data visualization, advanced networking and applications, cybersecurity, augmented and virtual reality, artificial intelligence and robotics, soft computing data science, and intelligent knowledge discovery. The book is useful, interesting, and informative for a wide range of scientists, engineers, and students.