This book introduces a holistic approach to ship design and its optimisation for life-cycle operation. It deals with the scientific background of the adopted approach and the associated synthesis model, which follows modern computer aided engineering (CAE) procedures. It integrates techno-economic databases, calculation and multi-objective optimisation modules and s/w tools with a well-established Computer-Aided Design (CAD) platform, along with a Virtual Vessel Framework (VVF), which will allow virtual testing before the building phase of a new vessel. The resulting graphic user interface (GUI) and information exchange systems enable the exploration of the huge design space to a much larger extent and in less time than is currently possible, thus leading to new insights and promising new design alternatives. The book not only covers the various stages of the design of the main ship system, but also addresses relevant major onboard systems/components in terms of life-cycle performance to offer readers a better understanding of suitable outfitting details, which is a key aspect when it comes the outfitting-intensive products of international shipyards. The book disseminates results of the EU funded Horizon 2020 project HOLISHIP.