Prions Prions Prions
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| Author | : Stanley B. Prusiner |
| Publisher | : Springer |
| Total Pages | : 163 |
| Release | : 1995-12-12 |
| Genre | : Medical |
| ISBN | : 9783540593430 |
A series of remarkable discoveries in the past three decades have led to the molecular and genetic characterization of the transmissible pathogen causing scrapie in animals and a quartet of human illnesses: kuru, Jakob-Creutzfeld disease, Gerstmann-Sträussler-Scheinker disease, and fatal familial insomnia. To distinguish this pathogen from viruses and viroids, the term "prion" was introduced to emphasize its proteinaceous and infectious nature. Stanley B. Prusiner, editor of this volume, was awarded the 1997 Nobel Prize in Physiology and Medicine for his pioneering discovery of prions. The book reviews advances in studies of prions, which - as considereable evidence indicates - are novel pathogens composed only of protein.
| Author | : Claudio Soto |
| Publisher | : CRC Press |
| Total Pages | : 191 |
| Release | : 2005-12-20 |
| Genre | : Medical |
| ISBN | : 142004012X |
Prion-related diseases, known as transmissible spongiform encephalopathies (TSEs), are infectious, fatal neurodegenerative disorders for which there is no cure, treatment, nor even a means for early diagnosis. The horrific advent of Mad Cow Disease -- transmitted to humans through eating meat from steers sickened by bovine spongiform encephalopathy
| Author | : Institute of Medicine |
| Publisher | : National Academies Press |
| Total Pages | : 125 |
| Release | : 2003-04-20 |
| Genre | : Medical |
| ISBN | : 0309087449 |
In Advancing Prion Science, the Institute of Medicine's Committee on Transmissible Spongiform Encephalopathies Assessment of Relevant Science recommends priorities for research and investment to the Department of Defense's National Prion Research Program (NPRP). Transmissible spongiform encephalopathies (TSEs), also called prion diseases, are invariably fatal neurodegenerative infectious diseases that include bovine spongiform encephalopathy (commonly called mad cow disease), chronic wasting disease, scrapie, and Creutzfeldt-Jakob disease. To develop antemortem diagnostics or therapies for TSEs, the committee concludes that NPRP should invest in basic research specifically to elucidate the structural features of prions, the molecular mechanisms of prion replication, the mechanisms of TSE pathogenesis, and the physiological function of prions' normal cellular isoform. Advancing Prion Science provides the first comprehensive reference on present knowledge about all aspects of TSEs' from basic science to the U.S. research infrastructure, from diagnostics to surveillance, and from prevention to treatment. This report summarizes the progress thus far.
| Author | : |
| Publisher | : Elsevier |
| Total Pages | : 520 |
| Release | : 2018-06-07 |
| Genre | : Medical |
| ISBN | : 0444639535 |
Human Prion Diseases, Volume 153 is designed to update the reader on the latest advances and clinical aspects of prion diseases. The book is organized into five sections, including the pathophysiology of prions and a description of animal and human diseases. This is followed by detailed reports on recent advances in diagnosis strategies for the development of novel anti-prion molecules and possible designs of clinical trials in such a rare disease. An introductory chapter gives an extensive historical background of prion research, with a final chapter highlighting recent progress, and more importantly, unsolved problems. - Offers an authoritative overview of prion diseases in humans, detailing the pathogenesis of the disease, clinical investigations, and the diagnosis of both the genetic and acquired forms - Provides clarity and context by presenting prion diseases in relation to other neurodegenerative diseases in humans - Emphasizes the unique properties of prion diseases and consequent problems they can cause, both clinically and in public health terms
| Author | : Stanley B. Prusiner |
| Publisher | : Yale University Press |
| Total Pages | : 344 |
| Release | : 2014-04-29 |
| Genre | : Science |
| ISBN | : 0300191146 |
The author, a 1997 recipient of the Noble Prize in medicine, describes the years he spent researching and demonstrating how the infectious proteins known as prions were responsible for brain diseases and how his theory has now become widely accepted in the science establishment.
| Author | : Brian K. Nunnally |
| Publisher | : CRC Press |
| Total Pages | : 456 |
| Release | : 2003-10-17 |
| Genre | : Medical |
| ISBN | : 9780203912973 |
The alarm sounded by Canada's confirmed case of bovine spongiform encephalopathy (BSE) has reaffirmed the exigency of establishing improved safeguards and more aggressive surveillance protocols in North America and around the world. Research converging on the probable causative agent--prion proteins--calls for intensive assessment of the headway gained in tracing prions, testing for transmissible neurodegenerative diseases, and developing methods for cornering the epidemic. With an illustrious panel of 36 international contributors, this timely book marshals techniques for prion protein assay and diagnosis of transmissible spongiform encephalopathies (TSEs).
| Author | : Stanley B. Prusiner |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2017 |
| Genre | : Medical |
| ISBN | : 9781621820932 |
Prions are infectious proteins responsible for diseases such as Creutzfeldt-Jakob disease and "mad cow" disease. They are misfolded versions of normal proteins that replicate by converting their normal cellular counterparts into abnormal prion proteins that disrupt cell function and can be transmitted to other cells and individuals. This book examines our under-standing of their structure, biochemistry, and pathophysiology.
| Author | : Jay Ingram |
| Publisher | : Yale University Press |
| Total Pages | : 294 |
| Release | : 2013-03-19 |
| Genre | : Medical |
| ISBN | : 0300189893 |
DIVThe story of the revolutionary science that is unraveling the mysteries of mad cow and other fatal brain diseases/div
| Author | : David R. Brown |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 498 |
| Release | : 2005-05-06 |
| Genre | : Medical |
| ISBN | : 9780387239224 |
This is the first and only book on the subject of prions to cover the cause of cell death in the disease. It covers the full range of competing theories on the subject, from broad description and basic points up to the final details of the basic science.
| Author | : Richard Rhodes |
| Publisher | : Simon and Schuster |
| Total Pages | : 305 |
| Release | : 2012-12-11 |
| Genre | : Philosophy |
| ISBN | : 1471104575 |
In this brilliant and gripping medical detective story. Richard Rhodes follows virus hunters on three continents as they track the emergence of a deadly new brain disease that first kills cannibals in New Guinea, then cattle and young people in Britain and France -- and that has already been traced to food animals in the United States. In a new Afterword for the paperback, Rhodes reports the latest U.S. and worldwide developments of a burgeoning global threat.
