Development of the Nervous System

Development of the Nervous System
Author: Dan H. Sanes
Publisher: Elsevier
Total Pages: 388
Release: 2005-11-02
Genre: Science
ISBN: 0080472494

Development of the Nervous System, Second Edition has been thoroughly revised and updated since the publication of the First Edition. It presents a broad outline of neural development principles as exemplified by key experiments and observations from past and recent times. The text is organized along a development pathway from the induction of the neural primordium to the emergence of behavior. It covers all the major topics including the patterning and growth of the nervous system, neuronal determination, axonal navigation and targeting, synapse formation and plasticity, and neuronal survival and death. This new text reflects the complete modernization of the field achieved through the use of model organisms and the intensive application of molecular and genetic approaches. The original, artist-rendered drawings from the First Edition have all been redone and colorized to so that the entire text is in full color. This new edition is an excellent textbook for undergraduate and graduate level students in courses such as Neuroscience, Medicine, Psychology, Biochemistry, Pharmacology, and Developmental Biology. Updates information including all the new developments made in the field since the first edition Now in full color throughout, with the original, artist-rendered drawings from the first edition completely redone, revised, colorized, and updated

Organizing Principles of Neural Development

Organizing Principles of Neural Development
Author: S. C. Sharma
Publisher: Springer Science & Business Media
Total Pages: 417
Release: 2013-03-13
Genre: Science
ISBN: 1468448021

This volume contains summaries of most of the invited presentations at the NATO Advanced Study Institute "Organizing Principles of Neural Development", held in Povoa de Varzim, Portugal, from June 1-12, 1982. The meeting was intended to bring together a select group of investigators to present their views on problems in the field and to foster extensive discussions in smaller groups. It was hoped that such communications would pique curiousity and creativity among the students and thus help in formulating additional hypotheses regarding the type of interactions which might underlie neural development. Despite the wide range of material covered at this institute, a common theme seemed to emerge: at all stages of their develop mental history, the cells of the nervous system interact with previously generated cells (both neurons and non-neurons) as well as with other constituents of the developmental milieu. The pre sentations at this meeting helped in comprehending how a relatively "simple" series of sequential events might provide the necessary information needed to generate the diversity, characteristic of the adult nervous system, without hypothesizing on the existence of specific genes acting to control each step.

Principles of Neural Design

Principles of Neural Design
Author: Peter Sterling
Publisher: MIT Press
Total Pages: 567
Release: 2015-05-22
Genre: Education
ISBN: 0262028700

Neuroscience research has exploded, with more than fifty thousand neuroscientists applying increasingly advanced methods. A mountain of new facts and mechanisms has emerged. And yet a principled framework to organize this knowledge has been missing. In this book, Peter Sterling and Simon Laughlin, two leading neuroscientists, strive to fill this gap, outlining a set of organizing principles to explain the whys of neural design that allow the brain to compute so efficiently. Setting out to "reverse engineer" the brain -- disassembling it to understand it -- Sterling and Laughlin first consider why an animal should need a brain, tracing computational abilities from bacterium to protozoan to worm. They examine bigger brains and the advantages of "anticipatory regulation"; identify constraints on neural design and the need to "nanofy"; and demonstrate the routes to efficiency in an integrated molecular system, phototransduction. They show that the principles of neural design at finer scales and lower levels apply at larger scales and higher levels; describe neural wiring efficiency; and discuss learning as a principle of biological design that includes "save only what is needed." Sterling and Laughlin avoid speculation about how the brain might work and endeavor to make sense of what is already known. Their distinctive contribution is to gather a coherent set of basic rules and exemplify them across spatial and functional scales.

Building Brains

Building Brains
Author: David J. Price
Publisher: John Wiley & Sons
Total Pages: 386
Release: 2017-11-29
Genre: Medical
ISBN: 111929388X

Provides a highly visual, readily accessible introduction to the main events that occur during neural development and their mechanisms Building Brains: An Introduction to Neural Development, 2nd Edition describes how brains construct themselves, from simple beginnings in the early embryo to become the most complex living structures on the planet. It explains how cells first become neural, how their proliferation is controlled, what regulates the types of neural cells they become, how neurons connect to each other, how these connections are later refined under the influence of neural activity, and why some neurons normally die. This student-friendly guide stresses and justifies the generally-held belief that a greater knowledge of how nervous systems construct themselves will help us find new ways of treating diseases of the nervous system that are thought to originate from faulty development, such as autism spectrum disorders, epilepsy, and schizophrenia. A concise, illustrated guide focusing on core elements and emphasizing common principles of developmental mechanisms, supplemented by suggestions for further reading Text boxes provide detail on major advances, issues of particular uncertainty or controversy, and examples of human diseases that result from abnormal development Introduces the methods for studying neural development, allowing the reader to understand the main evidence underlying research advances Offers a balanced mammalian/non-mammalian perspective (and emphasizes mechanisms that are conserved across species), drawing on examples from model organisms like the fruit fly, nematode worm, frog, zebrafish, chick, mouse and human Associated Website includes all the figures from the textbook and explanatory movies Filled with full-colorartwork that reinforces important concepts; an extensive glossary and definitions that help readers from different backgrounds; and chapter summaries that stress important points and aid revision, Building Brains: An Introduction to Neural Development, 2nd Edition is perfect for undergraduate students and postgraduates who may not have a background in neuroscience and/or molecular genetics. “This elegant book ranges with ease and authority over the vast field of developmental neuroscience. This excellent textbook should be on the shelf of every neuroscientist, as well as on the reading list of every neuroscience student.” —Sir Colin Blakemore, Oxford University “With an extensive use of clear and colorful illustrations, this book makes accessible to undergraduates the beauty and complexity of neural development. The book fills a void in undergraduate neuroscience curricula.” —Professor Mark Bear, Picower Institute, MIT. Highly Commended, British Medical Association Medical Book Awards 2012 Published with the New York Academy of Sciences

Principles of Computational Modelling in Neuroscience

Principles of Computational Modelling in Neuroscience
Author: David Sterratt
Publisher: Cambridge University Press
Total Pages: 553
Release: 2023-10-05
Genre: Science
ISBN: 1108483143

Learn to use computational modelling techniques to understand the nervous system at all levels, from ion channels to networks.