This publication, Water Quality in Agriculture: Risks and Risk Mitigation, emphasizes technical solutions and good agricultural practices, including risk mitigation measures suitable for the contexts of differently resourced institutions working in rural as well as urban and peri-urban settings in low- and middle-income countries. With a focus on sustainability of the overall land use system, the guidelines also cover possible downstream impacts of farm-level decisions. As each country has a range of site-specific conditions related to climate, soil and water quality, crop type and variety, as well as management options, subnational adjustments to the presented guidelines are recommended. Water Quality in Agriculture: Risks and Risk Mitigation, is intended for use by national and subnational governmental authorities, farm and project managers, extension officers, consultants and engineers to evaluate water quality data, and identify potential problems and solutions related to water quality. The presented guidelines will also be of value to the scientific research community and university students.The chapters in this publication address the following topics:Chapter 2 describes the linkages between water quality and achieving the United Nations Sustainable Development Goals, and the need for water quality monitoring. Chapter 3 provides an overview of existing water quality guidelines and standards across the world, including those reliant on technological advances and stringent water quality monitoring, and others based on health-based targets, as recommended by WHO. Chapter 4 is dedicated to pathogenic threats, in particular from domestic wastewater, while the elaborated Chapter 5 targets chemical risks with significant emphasis on salinity. The interlinkages between water quality and aquaculture and water quality and livestock production are described in Chapters 6 and 7, respectively. The importance of water quality for a healthy environment and ecology is explored in Chapter 8, and further extended to watersheds and river basin scales in Chapter 9, looking at the approaches used to analyze, monitor, and manage water quality, and possible downstream impacts in their larger geographical context. Finally, Chapter 10 provides an overview of the most common and/or significant barriers and drivers of relevance for the adoption of water reuse guidelines and best practices within a given regulatory and institutional context with special attention to low- and middle-income countries.