Practical Protein Crystallography
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Author | : Duncan E. McRee |
Publisher | : Academic Press |
Total Pages | : 403 |
Release | : 2012-12-02 |
Genre | : Science |
ISBN | : 0323138888 |
Designed for easy use by both new and experienced protein crystallographers, this much-needed book is for anyone interested in solving protein structures by the method of crystallography. It contains many examples ofactual experiments and data, including electron density maps. Computer methods and computer code samples are presented. Practical Protein Crystallography is loaded with new information on area detectors, synchrotron radiation techniques, and the latest computer methods, and features the XtalView software system. Graduate students and teachers in physical biochemistry and pharmaceutical researchers will find this text a timely and convenient aid.
Author | : Konstantinos Beis |
Publisher | : Royal Society of Chemistry |
Total Pages | : 244 |
Release | : 2018-06-19 |
Genre | : Science |
ISBN | : 1788014774 |
Protein crystallography has become vital to further understanding the structure and function of many complex biological systems. In recent years, structure determination has progressed tremendously however the quality of crystals and data sets can prevent the best results from being obtained. With contributions from world leading researchers whose software are used worldwide, this book provides a coherent approach on how to handle difficult crystallographic data and how to assess its quality. The chapters will cover all key aspects of protein crystallography, from instrumentation and data processing through to model building. This book also addresses challenges that protein crystallographers will face such as dealing with data from microcrystals and multi protein complexes. This book is ideal for both academics and researchers in industry looking for a comprehensive guide to protein crystallography.
Author | : Jan Drenth |
Publisher | : Springer Science & Business Media |
Total Pages | : 355 |
Release | : 2013-03-09 |
Genre | : Science |
ISBN | : 1475730926 |
New textbooks at all levels of chemistry appear with great regularity. Some fields such as basic biochemistry, organic reaction mechanisms, and chemical thermodynamics are well represented by many excellent texts, and new or revised editions are published sufficiently often to keep up with progress in research. However, some areas of chemistry, especially many of those taught at the graduate level, suffer from a real lack of up to-date textbooks. The most serious needs occur in fields that are rapidly changing. Textbooks in these subjects usually have to be written by scientists actually involved in the research that is advancing the field. It is not often easy to persuade such individuals to set time aside to help spread the knowledge they have accumulated. Our goal, in this series, is to pinpoint areas of chemistry where recent progress has outpaced what is covered in any available textbooks, and then seek out and persuade experts in these fields to produce relatively concise but instructive intro ductions to their fields. These should serve the needs of one-semester or one-quarter graduate courses in chemistry and biochemistry. In some cases, the availability of texts in active research areas should help stimulate the creation of new courses. Charles R. Cantor v Preface to the Second Edition Since the publication of the previous edition in 1994, X-ray crystallography of proteins has advanced by improvements in existing techniques and by addition of new techniques.
Author | : Alexander Wlodawer |
Publisher | : Humana Press |
Total Pages | : 672 |
Release | : 2017-06-02 |
Genre | : Science |
ISBN | : 9781493969982 |
This volume provides methods for modern macromolecular crystallography, including all steps leading to crystal structure determination and analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Protein Crystallography aims to ensure successful results in the further study of this vital field.
Author | : Alexander Wlodawer |
Publisher | : |
Total Pages | : 672 |
Release | : 2017 |
Genre | : Life sciences |
ISBN | : 9781493970001 |
Author | : Terese M. Bergfors |
Publisher | : Internat'l University Line |
Total Pages | : 505 |
Release | : 2009 |
Genre | : Medical |
ISBN | : 0972077448 |
Author | : Robert E. Babine |
Publisher | : John Wiley & Sons |
Total Pages | : 284 |
Release | : 2004-02-13 |
Genre | : Medical |
ISBN | : 9783527306787 |
The rational, structure-based approach has become standard in present-day drug design. As a consequence, the availability of high-resolution structures of target proteins is more often than not the basis for an entire drug development program. Protein structures suited for rational drug design are almost exclusively derived from crystallographic studies, and drug developers are relying heavily on the power of this method. Here, researchers from leading pharmaceutical companies present valuable first-hand information, much of it published for the first time. They discuss strategies to derive high-resolution structures for such important target protein classes as kinases or proteases, as well as selected examples of successful protein crystallographic studies. A special section on recent methodological developments, such as for high-throughput crystallography and microcrystallization, is also included. A valuable companion for crystallographers involved in protein structure determination as well as drug developers pursuing the structure-based approach for use in their daily work.
Author | : Lawrence C. Kuo |
Publisher | : Academic Press |
Total Pages | : 662 |
Release | : 2011-03-09 |
Genre | : Medical |
ISBN | : 0123812747 |
There are numerous excellent reviews on fragment-based drug discovery (FBDD), but there are to date no hand-holding guides or protocols with which one can embark on this orthogonal approach to complement traditional high throughput screening methodologies. This Methods in Enzymology volume offers the tools, practical approaches, and hit-to-lead examples on how to conduct FBDD screens. The chapters in this volume cover methods that have proven to be successful in generating leads from fragments, including chapters on how to apply computational techniques, nuclear magnetic resonance, surface plasma resonance, thermal shift and binding assays, protein crystallography, and medicinal chemistry in FBDD. Also elaborated by experienced researchers in FBDD are sample preparations of fragments, proteins, and GPCR as well as examples of how to generate leads from hits. Offers the tools, practical approaches, and hit-to-lead examples on how to conduct FBDD screens The chapters in this volume cover methods that have proven to be successful in generating leads from fragments, including chapters on how to apply computational techniques, nuclear magnetic resonance, surface plasma resonance, thermal shift and binding assays, protein crystallography, and medicinal chemistry in FBDD
Author | : Charles W. Carter |
Publisher | : Gulf Professional Publishing |
Total Pages | : 756 |
Release | : 1997 |
Genre | : Computer simulation |
ISBN | : 9780121827779 |
Annotation Accurate molecular structures is vital for rational drug design and for structure based functional studies directed toward the development of effective therapeutic agents and drugs. Crystallography can reliably predict structure, both in terms of folding and atomic details of bonding. * Phases * Map interpretation and refinement * Analysis and software.
Author | : Dennis Sherwood |
Publisher | : Oxford University Press |
Total Pages | : 640 |
Release | : 2011 |
Genre | : Language Arts & Disciplines |
ISBN | : 019955904X |
Information derived from X-ray crystal structures of biological molecules allows us to explain their functions in living organisms in extraordinary detail, and to develop drugs to treat disease. This book describes the principles and practice of X-ray diffraction as a key technique at the forefront of new discoveries in biology and medicine.