Hereditary Breast and Ovarian Cancer

Hereditary Breast and Ovarian Cancer
Author: Seigo Nakamura
Publisher: Springer Nature
Total Pages: 324
Release: 2021-10-20
Genre: Medical
ISBN: 9811645213

This highly informative and clearly written book presents the basic science and the latest data on hereditary breast and ovarian cancer (HBOC) to provide an up-to-date and holistic overview of the disease. It starts off by presenting the molecular mechanisms, genetic testing and counseling, and variants of unknown significance (VUS) to help readers understand the contemporary interpretation of the disease. Further chapters focus on the surveillance, diagnosis and treatment, including chemoprevention, risk reduction and drug development based on molecular mechanisms. It also includes a chapter on the latest findings from the HBOC database, ethical issues and the parp inhibitors, and discusses innovative thinking to manage and understand the disease. Hereditary Breast and Ovarian Cancer - Molecular Mechanism and Clinical Practice offers breast surgeons, medical oncologists, gynecological oncologists and genetic counselors a comprehensive overview of the disease. Providing insights into recent scientific findings and further avenues for investigation, it is also a thought-provoking and informative read for researchers and scholars.

Confronting Hereditary Breast and Ovarian Cancer

Confronting Hereditary Breast and Ovarian Cancer
Author: Sue Friedman
Publisher: JHU Press
Total Pages: 320
Release: 2012-03-01
Genre: Health & Fitness
ISBN: 1421404451

"Be informed. Be empowered. Be well." If you are concerned that the cancer in your family is hereditary, you face difficult choices. Should you have a blood test that may reveal whether you have a high likelihood of disease? Do you preemptively treat a disease that may never develop? How do you make decisions now that will affect the rest of your life? This helpful, informative guide answers your questions as you confront hereditary breast and ovarian cancer. Developed by Facing Our Risk of Cancer Empowered (FORCE), the nation’s only nonprofit organization dedicated to supporting families affected by hereditary breast and ovarian cancer, this book stands alone among breast and ovarian cancer resources. Equal parts health guide and memoir, it defines complex issues facing previvors and survivors and provides solutions with a fresh, authoritative voice. Written by three passionate advocates for the hereditary cancer community who are themselves breast cancer survivors, Confronting Hereditary Breast and Ovarian Cancer dispels myths and misinformation and presents practical risk-reducing alternatives and decision-making tools. Including information about genetic counseling and testing, preventive surgery, and fertility and family planning, as well as explanations of health insurance coverage and laws protecting genetic privacy, this resource tackles head-on the challenges of living in a high-risk body. Confronting hereditary cancer is a complex, confusing, and highly individual journey. With its unique combination of the latest research, expert advice, and compelling personal stories, this book gives previvors, survivors, and their family members the guidance they need to face the unique challenges of hereditary cancer.

Practical Guide to Hereditary Breast and Ovarian Cancer

Practical Guide to Hereditary Breast and Ovarian Cancer
Author: Daisuke Aoki
Publisher: Springer Nature
Total Pages: 147
Release: 2023-12-02
Genre: Medical
ISBN: 981995231X

This book shares cutting-edge evidence on Hereditary Breast and Ovarian Cancer (HBOC) treatment, delivering facts on breast cancer, gynecologic oncology, and basic research to contribute to clinicians' practices. Each chapter presents the latest clinical techniques, basic experimental results, and the best-chosen research findings. The book is based on the works presented at the Japanese Organization of Hereditary Brest and Ovarian Cancer (JOHBOC) and a special chapter delivers a study based on the extensive data from the Japanese HBOC patients registered in the society's database, presenting novel evidence for further advancement in the field. The practice for HBOC has been rapidly increasing due to the clinical development of poly(ADP-ribose) polymerase inhibitors and the spread of companion diagnostics. In addition, the insurance coverage of a part of HBOC treatment raised social awareness in Japan, and the book illustrates not only clinical efforts but also issues related to the social system and the efforts of the association of related organizations. Hereditary Breast and Ovarian Cancer – Annual meeting of JOHBOC will be of interest to breast surgeons, obstetricians and gynecologists, pancreatic cancer surgeons, and urologists engaged in HBOC treatment through the implementation of companion diagnostics for PARP inhibitors administration. Also, physicians occupied in genetic medicine who perform genetic testing and medical staff practicing HBOC will find this book insightful. It is also for HBOC patients and their families, medical administrators in the social system of HBOC practice. Editors and authors hope to contribute to the equalization and widespread of HBOC practice and serve as a foundation for future advances in the disease's treatment and medical practice.

Positive Results

Positive Results
Author: Joi L. Morris
Publisher: Prometheus Books
Total Pages: 397
Release: 2010-06-03
Genre: Health & Fitness
ISBN: 1615927735

This unique and important guidebook is a single, comprehensive source of information and advice to help women (and some men) at high risk for breast and for ovarian cancer because of family history and genetic profile. One part memoir, three parts "how to" manual, Positive Results explains in a clear and steady manner the myths and realities of "the breast cancer genes." It lays out all the options in easy-to-follow, compassionate language. It will help women and men decide if they want to pursue genetic testing, guide them in interpreting their test results, and give them a sound basis for making the life-saving decisions required to manage their risks. Authors Joi Morris and Dr. Ora Karp Gordon cover all of the latest medical options, including genetic testing for breast cancer risk, breast cancer surveillance, assessing risk, mastectomy and breast reconstruction techniques, ovarian cancer surveillance, surgery, managing menopause, and cancer risks in men who carry mutations on BRCA genes. Along the way, Joi tells her personal story and that of other women and men who have made the gut-wrenching decisions required to survive in this world of astronomical risk. At the age of forty-two, Joi learned that she has a genetic mutation on a gene known as BRCA2. The test results meant that her risk of getting breast cancer could be as high as 84 percent by age seventy, and that her risk for ovarian cancer was also high. Compounding her risk was the fact that her mother had developed breast cancer in her forties. After much research and consultation, the result of which is this book, Joi made the difficult decision of undergoing prophylactic mastectomies. This straightforward and practical approach combined with the poignant personal experience of a woman at risk facing these challenging decisions will provide readers with the feeling that they have had the benefit of a long conversation with both a trusted physician and a friend who has just gone through the same uncertainties they are facing.

Now What?

Now What?
Author: Amy Curran Baker
Publisher: Demos Medical Publishing
Total Pages: 199
Release: 2011-12-14
Genre: Health & Fitness
ISBN: 1617051012

All the information you need after mastectomy and breast reconstruction surgery so that you can focus on what matters most: healing and staying well. Why am I so tired all the time? What about these drains? Should I worry about lymphedema? Your mastectomy (with or without reconstruction) doesnít end when you leave the operating room. In Now What?, Amy Curran Baker, an occupational therapist who has had a double mastectomy and direct to implant breast reconstruction, and her co-authors, two registered nurses, answer all of your post-surgery questions in this comprehensive and empowering guide. Now What? helps you: Consider your options and make the decisions that are best for you Deal with frozen shoulder syndrome, wound care, swollen lymph nodes, and other side effects of mastectomy Organize the nitty-gritty issues of wound management post-op care with helpful charts and logs Hear real stories from other breast cancer survivors who have had a mastectomy

A Practical Guide to Human Cancer Genetics

A Practical Guide to Human Cancer Genetics
Author: Shirley V. Hodgson
Publisher: Cambridge University Press
Total Pages: 288
Release: 1999
Genre: Medical
ISBN: 9780521640251

This extensively updated and expanded edition provides the busy clinician with an essential overview of the latest developments in human cancer genetics--an area that has made significant advances since publication of the first edition. The opening section presents the principles of cancer genetics and introduces the basic concepts and mechanisms of tumorigenesis and inherited predisposition to cancer. The second part of the book provides information, on a systems basis, on the incidence, significance and management of predisposition to individual cancers. The final section deals with specific inherited cancer syndromes, giving practical guidance on clinical investigation, screening and management of affected patients and relatives at risk. The authors also provide up-to-date details of the genetic mapping of inherited cancer syndromes and the molecular genetic changes in individual cancers. Finally, an appendix provides a helpful revision guide to the fundamental principles of genetics. This practical and clear account will benefit clinicians and research workers in oncology, genetics, surgery and general medicine.

Clinical Gynecology

Clinical Gynecology
Author: Eric J. Bieber
Publisher: Cambridge University Press
Total Pages: 1127
Release: 2015-04-23
Genre: Medical
ISBN: 1107040396

Written with the busy practice in mind, this book delivers clinically focused, evidence-based gynecology guidance in a quick-reference format. It explores etiology, screening, tests, diagnosis, and treatment for a full range of gynecologic health issues. The coverage includes the full range of gynecologic malignancies, reproductive endocrinology and infertility, infectious diseases, urogynecologic problems, gynecologic concerns in children and adolescents, and surgical interventions including minimally invasive surgical procedures. Information is easy to find and absorb owing to the extensive use of full-color diagrams, algorithms, and illustrations. The new edition has been expanded to include aspects of gynecology important in international and resource-poor settings.

The Breast Reconstruction Guidebook

The Breast Reconstruction Guidebook
Author: Kathy Steligo
Publisher: JHU Press
Total Pages: 354
Release: 2012-11-01
Genre: Health & Fitness
ISBN: 1421407833

This guide helps women decide whether to have a breast reconstruction procedure after mastectomy—and, if so, which one. For a decade The Breast Reconstruction Guidebook has been the best resource on this topic for women who have had a mastectomy. Equal parts science and support, it is filled with stories that illustrate the emotional and physical components of breast reconstruction. Readers will find advice about choosing a doctor and a procedure, insurance and payment issues, how to prepare for surgery, and what to expect during recovery. Expert commentary by physicians and insights from patients inform this book, as does the exhaustive research by the author, a two-time breast cancer survivor who has twice had reconstructive surgery. New in this edition are discussions of • the pros and cons of saline and silicone implants • solutions for post-lumpectomy cosmetic problems • new immediate-delayed reconstruction when post-mastectomy radiation may be required • the benefits and limitations of nipple-sparing mastectomy • considerations for direct-to-implant reconstruction • newly developed tissue flap procedures • who can best apply nipple and areola tattoos and why tattoos may not last • enriching fat with stem cells so it stays in the breast • patient-controlled tissue expansion • how insurance and health care reform affect reconstruction

The Breast Cancer Book

The Breast Cancer Book
Author: Kenneth D. Miller
Publisher: JHU Press
Total Pages: 457
Release: 2021-09-28
Genre: Health & Fitness
ISBN: 142144190X

"Providing comprehensive, current, and reliable information on breast cancer, this book, written by an experienced oncologist, a surgeon, and a breast cancer survivor, informs and inspires readers, wherever they are in the breast cancer experience. Patient stories, essays from medical specialists, and illustrations add clarity and insight"--

Clinical Cancer Genetics

Clinical Cancer Genetics
Author: Kenneth Offit
Publisher: Wiley-Blackwell
Total Pages: 452
Release: 2030-05-07
Genre: Medical
ISBN: 9780471458937

Written by a world-recognized leader in this emerging field, Clinical Cancer Genetics provides an updated and expanded treatment of Kenneth Offit's seminal text on the clinical management associated with syndromes of cancer predisposition, with a thorough review of the relevant molecular genetics. This second edition features new coverage of pharmacogenetics, gene therapy trials, high throughput genotyping, and microarrays and includes a new focus on epigenetic events in carcinogenesis within background chapter on cancer genetics. Expanded coverage highlights more uncommon and rare cancer predisposition syndromes.