This issue of Clinics in Geriatric Medicine, guest edited by Mary Ann Zagaria, PharmD, is devoted to Polypharmacy. Articles in this outstanding issue include: Centers for Medicare and Medicaid Services Support for Medication Therapy Management (Enhanced Medication Therapy Management): Testing Strategies for Improving Medication Use Among Beneficiaries Enrolled in Medicare Part D; The Role of Patient Preferences in Deprescribing; Polypharmacy Reduction Strategies: Tips on Incorporating American Geriatrics Society Beers and Screening Tool of Older People’s Prescriptions Criteria; Polypharmacy and Delirium in Critically Ill Older Adults: Recognition and Prevention; Geriatric Polypharmacy: Pharmacist as Key Facilitator in Assessing for Falls Risk; Medication Reconciliation in Long-Term Care and Assisted Living Facilities: Opportunity for Pharmacists to Minimize Risks Associated with Transitions of Care; Can Managed Care Manage Polypharmacy?; Medication Risk Mitigation: Coordinating and Collaborating with Health Care Systems, Universities, and Researchers to Facilitate the Design and Execution of Practice-Based Research; and Geriatric Polypharmacy: Two Physicians’ Personal Perspectives.