Polyethylene Glycol
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Author | : J. Milton Harris |
Publisher | : Springer Science & Business Media |
Total Pages | : 395 |
Release | : 2013-11-21 |
Genre | : Medical |
ISBN | : 1489907033 |
The idea for this book came from discussions among participants in a symposium on biotechnical applications at the "Pacifichem 89" meeting in Honolulu. It was the majority opinion of this group that a volume dedicated to biotechnical and biomedical applications of PEG chemistry would enhance research and development in this area. Though the book was conceived at the Honolulu meeting, it is not a proceedings of this symposium. Several groups who did not participate in this meeting are repre sented in the book, and the book incorporates much work done after the meeting. The book does not include contributions in all related areas to which PEG chemistry has been applied. Several invited researchers declined to parti.:ipate, and there is not enough space in this single volume to properly cover all submissions. Chapter I-an overview of the topic-discusses in brief applications not given detailed coverage in specifically devoted chapters. The following topics are covered: introduction to and fundamental properties of PEG and derivatives in Chapters 1-3; separations using aqueous polymer two-phase partitioning in Chapters 4-6; PEG-proteins as catalysts in biotechnical applications in Chapters 7 and 8; biomedical applications of PEG-proteins in Chapters 9-13; PEG modified surfaces for a variety of biomedical and biotechnical applications in Chapters 14-20; and synthesis of new PEG derivatives in Chapters 21 and 22.
Author | : J. Milton Harris |
Publisher | : |
Total Pages | : 512 |
Release | : 1997 |
Genre | : Science |
ISBN | : |
This volume provides an interdisciplinary analysis of current biological applications of poly(ethylene glycol) (PEG). It includes a wide array of topics useful to materials scientists, organic chemists, biochemists, and bioengineers interested in drug delivery systems, pharmaceuticals and other biomaterials. The applications discussed include PEG-modified proteins, liposomes, drugs, surfaces of materials, and hydrogels. The volume also includes a review of PEG-oligonucleotides and a concise summary of the toxicology of PEG and its derivatives.
Author | : Francesco M. Veronese |
Publisher | : Springer Science & Business Media |
Total Pages | : 289 |
Release | : 2009-12-30 |
Genre | : Medical |
ISBN | : 3764386797 |
PEGylation technology and key applications are introduced by this topical volume. Basic physical and chemical properties of PEG as basis for altering/improving in vivo behaviour of PEG-conjugates such as increased stability, improved PK/PD, and decreased immunogenicity, are discussed. Furthermore, chemical and enzymatic strategies for the coupling and the conjugate characterization are reported. Following chapters describe approved and marketed PEG-proteins and PEG-oligonucleotides as well as conjugates in various stages of clinical development.
Author | : Zhen-Zhen Yang |
Publisher | : Springer Science & Business Media |
Total Pages | : 88 |
Release | : 2012-08-10 |
Genre | : Science |
ISBN | : 3642312683 |
In this volume, Professor He and his coworkers summarize polyethylene glycol (PEG)-promoted CO2 chemistry on the basis of understanding about phase behavior of PEG/CO2 system and reaction mechanism at molecular level. As PEG could be utilized as a green replacement for organic solvents, phase-transfer catalyst, surfactant, support in various reaction systems, significantly promoting catalytic activity and recovering expensive metal catalysts, particularly regarded as a CO2-philic material, the authors focus on special applications of PEG in CO2 capture and utilization, including PEG-functionalized catalysts for efficient transformation of CO2 and PEG-functionalized absorbents for efficient CO2 capture. Furthermore, they describe carbon capture and utilization strategy as an alternative approach to address the energy penalty problem in carbon capture and storage. Interestingly, the authors also discuss PEG radical chemistry in dense CO2 as rather creative and unusual use of PEG, presumably serves as a reaction medium and a radical initiator for radical chemistry.
Author | : National Academies of Sciences, Engineering, and Medicine |
Publisher | : National Academies Press |
Total Pages | : 775 |
Release | : 2018-05-18 |
Genre | : Medical |
ISBN | : 030946837X |
Millions of Americans use e-cigarettes. Despite their popularity, little is known about their health effects. Some suggest that e-cigarettes likely confer lower risk compared to combustible tobacco cigarettes, because they do not expose users to toxicants produced through combustion. Proponents of e-cigarette use also tout the potential benefits of e-cigarettes as devices that could help combustible tobacco cigarette smokers to quit and thereby reduce tobacco-related health risks. Others are concerned about the exposure to potentially toxic substances contained in e-cigarette emissions, especially in individuals who have never used tobacco products such as youth and young adults. Given their relatively recent introduction, there has been little time for a scientific body of evidence to develop on the health effects of e-cigarettes. Public Health Consequences of E-Cigarettes reviews and critically assesses the state of the emerging evidence about e-cigarettes and health. This report makes recommendations for the improvement of this research and highlights gaps that are a priority for future research.
Author | : G. W. A. Milne |
Publisher | : John Wiley & Sons |
Total Pages | : 1205 |
Release | : 2005-09-02 |
Genre | : Technology & Engineering |
ISBN | : 0471736619 |
An exhaustive resource for the industrial chemical community Through eleven editions, Gardner's Chemical Synonyms and Trade Names has become the best-known and most widely used source of information on chemicals in commerce. This companion book reflects the continuing research underlying Gardner's and presents a major expansion of the information provided for individual chemical compounds. Gardner's Commercially Important Chemicals: Synonyms, Trade Names, and Properties: * Contains 4,174 chemical entries and information such as structure, molecular formula, and chemical name * Includes synonyms for each chemical, including other identifiers, chemical names, trade names, and trivial names, in English and other languages * Provides chemical properties of the compounds, information concerning known uses of the chemical and biological data-in particular, acute toxicity in various species, where available * Lists the companies that manufacture or supply the listed chemicals * Describes bulk inorganic chemicals, major pesticides (herbicides, insecticides, antifungal agents, etc.), and many dyestuffs, surfactants, and metals, along with the most commonly used drugs * Contains indexes by chemical name and synonym, Chemical Abstracts Service (CAS) Registry Numbers, and EINECS (European Inventory of Existing Commercial Substances) numbers One useful feature of this database is the inclusion of physical properties and use data for pure chemicals. Properties that have been provided, when available, include: the melting point, boiling point, density or specific gravity, optical rotation, ultraviolet absorption, solubility, and acute toxicity. The major uses of most of the chemicals are indicated and, where appropriate, regulatory information is also provided.
Author | : United States. Environmental Protection Agency. Office of Toxic Substances |
Publisher | : |
Total Pages | : 808 |
Release | : 1979 |
Genre | : Chemical industry |
ISBN | : |
Author | : Sarfaraz K. Niazi |
Publisher | : CRC Press |
Total Pages | : 614 |
Release | : 2019-12-06 |
Genre | : Medical |
ISBN | : 1351593323 |
The Handbook of Pharmaceutical Manufacturing Formulations, Third Edition: Volume Four, Semisolid Products is an authoritative and practical guide to the art and science of formulating drugs for commercial manufacturing. With thoroughly revised and expanded content, this fourth volume of a six-volume set, compiles data from FDA and EMA new drug applications, patents and patent applications, and other sources of generic and proprietary formulations including author’s own experience, to cover the broad spectrum of cGMP formulations and issues in using these formulations in a commercial setting. A must-have collection for pharmaceutical manufacturers, educational institutions, and regulatory authorities, this is an excellent platform for drug companies to benchmark their products and for generic companies to formulate drugs coming off patent. Features: Largest source of authoritative and practical formulations, cGMP compliance guidance and self-audit suggestions Differs from other publications on formulation science in that it focuses on readily scalable commercial formulations that can be adopted for cGMP manufacturing Tackles common difficulties in formulating drugs and presents details on stability testing, bioequivalence testing, and full compliance with drug product safety elements Written by a well-recognized authority on drug and dosage form development including biological drugs and alternative medicines
Author | : Sarfaraz K. Niazi |
Publisher | : CRC Press |
Total Pages | : 646 |
Release | : 2016-04-19 |
Genre | : Medical |
ISBN | : 1420081179 |
The largest category of pharmaceutical formulations, comprising almost two-thirds of all dosage forms, compressed solids present some of the greatest challenges to formulation scientists. The first volume, Compressed Solid Products, tackles these challenges head on.Highlights from Compressed Solid Products, Volume One include:formulations for
Author | : G. B. Broun |
Publisher | : Springer Science & Business Media |
Total Pages | : 463 |
Release | : 2012-12-06 |
Genre | : Science |
ISBN | : 1468469851 |
The unique catalytic properties of enzymes and the numerous techniques for immobilization of enzymes and cells continue to maintain a high degree of practical and scientific interest in this area called Enzyme Engineering. This fourth International Enzyme Engineering Confer ence was the first to be held outside of the United States. Europe was chosen as the site primarily to en able greater participation by investigators from that continent. The Engineering Foundation of New York, which was the principal sponsor of the first three conferences, was most fortunate in having the DECHEMA (Deutsche Gesell schaft fur chemisches Apparatewesen e. V.) of Frankfurt (Main), F. R. Germany as the cosponsor for this fourth conference. The success of the conference also was due in large part to the generous financial support, especially by the government of the Federal Republic of Germany, as well as by European enzyme and chemical companies. The fourth conference, held September 25-30, 1977 at Bad Neuenahr, Federal Republic of Germany was certainly successful, with 240 participants from 23 countries, repre senting many academic disciplines and occupational special ties. At this conference special emphasis was placed on the immobilization of whole cells and organelles, medical applications of immobilized enzymes and organelles, and the industrial status and future for immobilized biological materials.