Polarized Light In Biomedical Imaging And Sensing
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| Author | : Jessica C. Ramella-Roman |
| Publisher | : Springer Nature |
| Total Pages | : 362 |
| Release | : 2022-11-14 |
| Genre | : Technology & Engineering |
| ISBN | : 3031047419 |
This book focuses on biomedical applications of polarized light, covering instrumentation and modeling specific to the field. This will be the first book, written by leading researchers in the field, to tackle this important topic. Readers will learn the fundamentals of polarized light transport and how to develop instrumentation for clinical and preclinical studies. They will also become familiar with the latest advancement in data analysis and image processing for a variety of medical applications. The book is dedicated specifically to the biomedical community, including scientists, engineers, and physicians working on the development of instrumentation for clinical and preclinical use. Emphasizes biomedical imaging and sensing; Describes new computational approaches with examples; Provides detailed descriptions of novel instrumentation.
| Author | : Valery V. Tuchin |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 281 |
| Release | : 2006-10-12 |
| Genre | : Science |
| ISBN | : 3540453210 |
Optical Polarization in Biomedical Applications introduces key developments in optical polarization methods for quantitative studies of tissues, while presenting the theory of polarization transfer in a random medium as a basis for the quantitative description of polarized light interaction with tissues. This theory uses the modified transfer equation for Stokes parameters and predicts the polarization structure of multiple scattered optical fields. The backscattering polarization matrices (Jones matrix and Mueller matrix) important for noninvasive medical diagnostic are introduced. The text also describes a number of diagnostic techniques such as CW polarization imaging and spectroscopy, polarization microscopy and cytometry. As a new tool for medical diagnosis, optical coherent polarization tomography is analyzed. The monograph also covers a range of biomedical applications, among them cataract and glaucoma diagnostics, glucose sensing, and the detection of bacteria.
| Author | : Casey William-Munz Pirnstill |
| Publisher | : |
| Total Pages | : |
| Release | : 2015 |
| Genre | : |
| ISBN | : |
Utilization of polarized light for improved specificity and sensitivity in disease diagnosis is occurring more often in fields of sensing, measurement, and medical diagnostics. This dissertation focuses on two distinct areas where polarized light is applied in biomedical sensing/monitoring: The first portion of worked reported in this dissertation focuses on addressing several major obstacles that exist prohibiting the use of polarized light as a means of developing an optical based non-invasive polarimetric glucose sensor to improve the quality of life and disease monitoring for millions of people currently afflicted by diabetes mellitus. In this work there are two key areas, which were focused on that require further technical advances for the technology to be realized as a viable solution. First, in vivo studies performed on New Zealand White (NZW) rabbits using a dual-wavelength polarimeter were conducted to allow for performance validation and modeling for predictive glucose measurements accounting for the time delay associated with blood aqueous humor glucose concentrations in addition to overcoming motion induced birefringence utilizing multiple linear regression analysis. Further, feasibility of non-matched index of refraction eye coupling between the system and corneal surface was evaluated using modeling and verified with in vitro testing validation. The system was initially modeled followed by construction of the non-matched coupling configuration for testing in vitro. The second half of the dissertation focuses on the use of polarized light microscopy designed, built, and tested as a low-cost high quality cellphone based polarimetric imaging system to aid medical health professionals in improved diagnosis of disease in the clinic and in low-resource settings. Malaria remains a major global health burden and new methods for, low-cost, high-sensitivity diagnosis of malaria are needed particularly in remote low-resource areas throughout the world. Here, a cost effective optical cell-phone based transmission polarized light microscope system is presented utilized for imaging the malaria pigment known as hemozoin. Validation testing of the optical resolution required to provide diagnosis similar to commercial polarized imaging systems will be conducted and the optimal design will be utilized in addition to image processing to improve the diagnostic capability. The electronic version of this dissertation is accessible from http://hdl.handle.net/1969.1/155527
| Author | : Irina Leonidovna Tarasova |
| Publisher | : Springer Nature |
| Total Pages | : 258 |
| Release | : |
| Genre | : |
| ISBN | : 3031642775 |
| Author | : Nirmal Mazumder |
| Publisher | : Springer Nature |
| Total Pages | : 455 |
| Release | : 2023-07-25 |
| Genre | : Science |
| ISBN | : 3031318528 |
This book focuses on polarization microscopy, a powerful optical tool used to study anisotropic properties in biomolecules, and its enormous potential to improve diagnostic tools for various biomedical research. The interaction of polarized light with normal and abnormal regions of tissue reveals structural information associated with its pathological condition. Diagnosis using conventional microscopy can be time-consuming, as pathologists require an hour to freeze and stain tissue slices from suspected patients. In comparison, polarization microscopy more quickly distinguishes abnormal tissue and provides better microstructural information of samples, even in the absence of staining. This book provides a basic understanding of the properties of polarized light, a description of the polarization microscope, and a mathematical formalism of Mueller matrix polarimetry. The authors discuss various advanced linear and nonlinear optical techniques such as optical coherence tomography (OCT), reflectance and transmission spectroscopy, fluorescence, multiphoton excitation, second harmonic generation, Raman microscopy, and more. They explore the exciting potential of integrating polarimetry with these techniques for possible applications in different areas of biomedical research, as well as the associated challenges. Including the most recent developments on the topic, this book serves as a modern guide to polarization microscopy and advancements in its use in biomedical research.
| Author | : Yongqiang Zhao |
| Publisher | : Springer |
| Total Pages | : 201 |
| Release | : 2016-03-09 |
| Genre | : Technology & Engineering |
| ISBN | : 366249373X |
This book introduces the optical multi-band polarization imaging theory and the utilization of the multi-band polarimetric information for detecting the camouflage object and the optical hidden marker, and enhancing the visibility in bad weather and water. The book describes systematically and in detail the basic optical polarimetry theory; provides abundant multi-band polarimetric imaging experiment data; and indicates practical evaluation methods for designing the multi-band polarization imager, for analyzing and modeling the object’s multi-band polarization characteristics, and for enhancing the vision performance in scattering media. This book shows the latest research results of multi-band polarimetric vision, especially in camouflage object detection, optical hidden marker detection and multi-band polarimetric imagery fusion. From this book, readers can get a complete understanding about multi-band polarimetric imaging and its application in different vision tasks.
| Author | : Justin Shekwoga Baba |
| Publisher | : |
| Total Pages | : |
| Release | : 2003 |
| Genre | : |
| ISBN | : |
Polarized light has the ability to increase the specificity of the investigation of biomedical samples and is finding greater utilization in the fields of medical diagnostics, sensing, and measurement. In particular, this dissertation focuses on the application of polarized light to address a major obstacle in the development of an optical based polarimetric non-invasive glucose detector that has the potential to improve the quality of life and prolong the life expectancy of the millions of people afflicted with the disease diabetes mellitus. By achieving the mapping of the relative variations in rabbit corneal birefringence, it is hoped that the understanding of the results contained herein will facilitate the development of techniques to eliminate the effects of changing corneal birefringence on polarimetric glucose measurement through the aqueous humor of the eye. This dissertation also focuses on the application of polarized light to address a major downside of cardiovascular biomechanics research, which is the utilization of toxic chemicals to prepare samples for histological examination. To this end, a polarization microscopy image processing technique is applied to non-stained cardiovascular samples as a means to eliminate, for certain cardiac samples, the necessity for staining using toxic chemicals. The results from this work have the potential to encourage more investigators to join the field of cardiac biomechanics, which studies the remodeling processes responsible for cardiovascular diseases such as myocardial infarct (heart attacks) and congestive heart failure. Cardiovascular disease is epidemic, particularly amongst the population group older than 65 years, and the number of people affected by this disease is expected to increase appreciably as the baby boomer generation transitions into this older, high risk population group. A better understanding of the responsible mechanisms for cardiac tissue remodeling will facilitate the development of better prevention and treatment regimens by improving the early detection and diagnosis of this disease.
| Author | : Xiaobo Li |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2024-07-31 |
| Genre | : Science |
| ISBN | : 9783725817320 |
As a fundamental property of the light wave, polarization information can be used to reveal the light and target's physical properties, such as the material, thickness, surface features, refractive index, etc. Thanks to the unique advantages of polarization information, polarimetry and polarimetric imager techniques have promising applications in several fields, including object detection, biomedical imaging, remote sensing, astronomical observation, the characterization of surfaces and thin films, optical communication, etc. The theories, instruments, and interpretation methods for polarimetry and polarimetric imaging are constantly developing; therefore, improving the performance of polarimetry and polarimetric imagers and exploring related applications are still necessary to address existing challenges and expand the potential of polarimetric imaging. "Advanced Polarimetry and Polarimetric Imaging" highlights new theories in and applications of advanced polarimeters and polarimetric imaging. Seventeen manuscripts were submitted to this reprint. This reprint on polarization technology illustrates the field's notable progress and potential. It features research articles that introduce innovative solutions and tackle key challenges in polarimetric image restoration, 3D reconstruction, high-speed Mueller ellipsometry, and P-lidar. These promising applications and novel approaches in polarimetry and imaging technology herald a promising future.
| Author | : Tuan Vo-Dinh |
| Publisher | : CRC Press |
| Total Pages | : 772 |
| Release | : 2014-07-29 |
| Genre | : Medical |
| ISBN | : 1420085166 |
Shaped by Quantum Theory, Technology, and the Genomics Revolution The integration of photonics, electronics, biomaterials, and nanotechnology holds great promise for the future of medicine. This topic has recently experienced an explosive growth due to the noninvasive or minimally invasive nature and the cost-effectiveness of photonic modalities in medical diagnostics and therapy. The second edition of the Biomedical Photonics Handbook presents recent fundamental developments as well as important applications of biomedical photonics of interest to scientists, engineers, manufacturers, teachers, students, and clinical providers. The third volume, Therapeutics and Advanced Biophotonics, focuses on therapeutic modalities, advanced biophotonic technologies, and future trends. Represents the Collective Work of over 150 Scientists, Engineers, and Clinicians Designed to display the most recent advances in instrumentation and methods, as well as clinical applications in important areas of biomedical photonics to a broad audience, this three-volume handbook provides an inclusive forum that serves as an authoritative reference source for a broad audience involved in the research, teaching, learning, and practice of medical technologies. What’s New in This Edition: A wide variety of photonic biochemical sensing technologies has already been developed for clinical monitoring of early disease states and physiological parameters, such as blood pressure, blood chemistry, pH, temperature, and the presence of pathological organisms or biochemical species of clinical importance. Advanced photonic detection technologies integrating the latest knowledge of genomics, proteomics, and metabolomics allow sensing of early disease states, thus revolutionizing the medicine of the future. Nanobiotechnology has opened new possibilities for detection of biomarkers of disease, imaging single molecules and in situ diagnostics at the single-cell level. In addition to these state-of-the-art advancements, the second edition contains new topics and chapters including: • Fiber Optic Probe Design • Laser and Optical Radiation Safety • Photothermal Detection • Multidimensional Fluorescence Imaging • Surface Plasmon Resonance Imaging • Molecular Contrast Optical Coherence Tomography • Multiscale Photoacoustics • Polarized Light for Medical Diagnostics • Quantitative Diffuse Reflectance Imaging • Interferometric Light Scattering • Nonlinear Interferometric Vibrational Imaging • Nanoscintillator-Based Therapy • SERS Molecular Sentinel Nanoprobes • Plasmonic Coupling Interference Nanoprobes Comprised of three books: Volume I: Fundamentals, Devices, and Techniques; Volume II: Biomedical Diagnostics; and Volume III: Therapeutics and Advanced Biophotonics, this second edition contains eight sections, and provides introductory material in each chapter. It also includes an overview of the topic, an extensive collection of spectroscopic data, and a list of references for further reading.
| Author | : Dennis H. Goldstein |
| Publisher | : CRC Press |
| Total Pages | : 809 |
| Release | : 2017-12-19 |
| Genre | : Technology & Engineering |
| ISBN | : 143983041X |
Polarized light is a pervasive influence in our world—and scientists and engineers in a variety of fields require the tools to understand, measure, and apply it to their advantage. Offering an in-depth examination of the subject and a description of its applications, Polarized Light, Third Edition serves as a comprehensive self-study tool complete with an extensive mathematical analysis of the Mueller matrix and coverage of Maxwell’s equations. Links Historical Developments to Current Applications and Future Innovations This book starts with a general description of light and continues with a complete exploration of polarized light, including how it is produced and its practical applications. The author incorporates basic topics, such as polarization by refraction and reflection, polarization elements, anisotropic materials, polarization formalisms (Mueller–Stokes and Jones) and associated mathematics, and polarimetry, or the science of polarization measurement. New to the Third Edition: A new introductory chapter Chapters on: polarized light in nature, and form birefringence A review of the history of polarized light, and a chapter on the interference laws of Fresnel and Arago—both completely re-written A new appendix on conventions used in polarized light New graphics, and black-and-white photos and color plates Divided into four parts, this book covers the fundamental concepts and theoretical framework of polarized light. Next, it thoroughly explores the science of polarimetry, followed by discussion of polarized light applications. The author concludes by discussing how our polarized light framework is applied to physics concepts, such as accelerating charges and quantum systems. Building on the solid foundation of the first two editions, this book reorganizes and updates existing material on fundamentals, theory, polarimetry, and applications. It adds new chapters, graphics, and color photos, as well as a new appendix on conventions used in polarized light. As a result, the author has re-established this book’s lofty status in the pantheon of literature on this important field.
