Recent wireless communication research faces the challenge of meeting a predicted 1000x increase in demand for wireless Internet data over the next decade. Among the key reasons for such explosive increase in demand include the evolution of Internet as a provider of high-definition video entertainment and two-way video communication, accessed via mobile wireless devices. One way to meet some of this demand is by using multiple antennae at the transmitter and receiver in a wireless device. For example, a system with 4 transmit and 4 receive antennae can provide up to a 4x increase in data throughput. Another key aspect of the overall solution would require sharing radio frequency spectral resources among users, causing severe amounts of interference to wireless systems. Consequently, wireless receivers with multiple antennae would be deployed in network environments that are rife with interference primarily due to wireless resource sharing among users. Other significant sources of interference include computational platform subsystems, signal leakage, and external electronics. Interference causes severe degradation in communication performance of wireless receivers. Having accurate statistical models of interference is a key requirement to designing, and analyzing the communication performance of, multi-antenna wireless receivers in the presence of interference. Prior work on statistical modeling of interference in multi-antenna receivers utilizes either the Gaussian distribution, or non-Gaussian distributions exhibiting either statistical independence or spherical isotropy. This dissertation proposes a framework, based on underlying statistical-physical mechanism of interference generation and propagation, for modeling multi-antenna interference in various network topologies. This framework can model interference which is spherically isotropic, or statistically independent, or somewhere on a continuum between these two extremes. The dissertation then utilizes the derived statistical models to analyze communication performance of multi-antenna receivers in interference-limited wireless networks. Accurate communication performance analysis can highlight the tradeoffs between communication performance and computational complexity of various multi-antenna receiver designs. Finally, using interference statistics, this dissertation proposes receiver algorithms that best mitigate the impact of interference on communication performance. The proposed algorithms include multi-antenna combining strategies, as well as, antenna selection algorithms for cooperative communications.