Computational Phytochemistry

Computational Phytochemistry
Author: Satyajit Dey Sarker
Publisher: Elsevier
Total Pages: 532
Release: 2024-03-15
Genre: Science
ISBN: 0443161038

Computational Phytochemistry, Second Edition, explores how recent advances in computational techniques and methods have been embraced by phytochemical researchers to enhance many of their operations, refocusing and expanding the possibilities of phytochemical studies. By applying computational aids and mathematical models to extraction, isolation, structure determination, and bioactivity testing, researchers can obtain highly detailed information about phytochemicals and optimize working approaches. This book aims to support and encourage researchers currently working with or looking to incorporate computational methods into their phytochemical work. Topics in this book include computational methods for predicting medicinal properties, optimizing extraction, isolating plant secondary metabolites, and building dereplicated phytochemical libraries. The roles of high-throughput screening, spectral data for structural prediction, plant metabolomics, and biosynthesis are all reviewed before the application of computational aids for assessing bioactivities and virtual screening is discussed. Illustrated with detailed figures and supported by practical examples, this book is an indispensable guide for all those involved with the identification, extraction, and application of active agents from natural products. This new edition captures remarkable advancements in mathematical modeling and computational methods that have been incorporated in phytochemical research, addressing, e.g., extraction, isolation, structure determination, and bioactivity testing of phytochemicals. Includes step-by-step protocols for various computational and mathematical approaches applied to phytochemical research Features clearly illustrated chapters contributed by highly reputable researchers Covers all key areas in phytochemical research, including virtual screening and metabolomics

Phytochemistry: An in-silico and in-vitro Update

Phytochemistry: An in-silico and in-vitro Update
Author: Shashank Kumar
Publisher: Springer
Total Pages: 575
Release: 2019-06-25
Genre: Science
ISBN: 9811369208

Phytochemistry is the branch of science that deals with the study of plant-derived chemicals or compounds, which are also known as phytochemicals or plant-derived secondary metabolites. Plants are known to produce phytochemicals that are essential for their growth and reproduction, as they protect them from insects, pathogens, and herbivores. Some of the major groups of plant-derived secondary metabolites are phenolics, flavonoids, terpenoids, alkaloids, tannin etc. Plant-derived phytochemicals are pharmacologically active and have the potential to cure various human diseases and disorders. Natural plant products have been known for their medicinal properties for untold years, and form the basis of several medicinal systems such as Chinese, Unani, and Ayurvedic Medicine. This book offers an essential introduction to phytochemicals and their synthetic analogues. It discusses various in silico approaches used to identify pharmacologically active phytochemicals and their biological activities, as well as in vitro and in vivo models/assays that have been utilized for the pharmacological profiling of plant-derived products to combat cancer, diabetes, cardiovascular diseases and neurological disorders. The intended audience includes upper-level undergraduate and graduate students; researchers and scientists from the pharmaceutical/food chemistry/nutrition sciences/biochemistry, and clinical biochemistry fields; and medical students. Sharing the latest findings, the book will familiarize these readers with the concepts, chemistry, and tremendous potential of phytochemistry.

Phytochemical Methods

Phytochemical Methods
Author: Jeffrey B. Harborne
Publisher: Springer Science & Business Media
Total Pages: 346
Release: 2012-12-06
Genre: Science
ISBN: 9400959214

While there are many books available on methods of organic and biochemical analysis, the majority are either primarily concerned with the application of a particular technique (e.g. paper chromatography) or have been written for an audience of chemists or for biochemists work ing mainly with animaltissues. Thus, no simple guide to modern metho ds of plant analysis exists and the purpose of the present volume is to fill this gap. It is primarily intended for students in the plant sciences, who have a botanical or a general biological background. It should also be of value to students in biochemistry, pharmacognosy, food science and 'natural products' organic chemistry. Most books on chromatography, while admirably covering the needs of research workers, tend to overwhelm the student with long lists of solvent systems and spray reagents that can be applied to each class of organic constituent. The intention here is to simplify the situation by listing only a few specially recommended techniques that have wide currency in phytochemical laboratories. Sufficient details are provided to allow the student to use the techniques for themselves and most sections contain some introductory practical experiments which can be used in classwork.

Textbook of Pharmacognosy & Phytochemistry

Textbook of Pharmacognosy & Phytochemistry
Author: Dr Biren Shah
Publisher: Elsevier India
Total Pages: 48
Release: 2013-11-01
Genre: Medical
ISBN: 8131234584

This comprehensive textbook primarily aims at fulfilling the syllabus requirements of B.Pharm. students. It is specifically designed to impart knowledge about the alternative systems of medicine and modern pharmacognosy. Additionally, it will also serve as a valuable information resource to other health sciences students and researchers working in the field of herbal technology.

Plant Biochemistry

Plant Biochemistry
Author: Hans-Walter Heldt
Publisher: Academic Press
Total Pages: 658
Release: 2005
Genre: Medical
ISBN: 0120883910

1 A Leaf Cell Consists of Several Metabolic Compartments 2 The Use of Energy from Sunlight by Photosynthesis is the Basis of Life on Earth 3 Photosynthesis is an Electron Transport Process 4 ATP is Generated by Photosynthesis 5 Mitochondria are the Power Station of the Cell 6 The Calvin Cycle Catalyzes Photosynthetic CO2 Assimilation 7 In the Photorespiratory Pathway Phosphoglycolate Formed by the Oxygenase Activity of RubisCo is Recycled 8 Photosynthesis Implies the Consumption of Water 9 Polysaccharides are Storage and Transport Forms of Carbohydrates Produced by Photosynthesis 10Nitrate Assimilation is Essential for the Synthesis of Organic Matter 11 Nitrogen Fixation Enables the Nitrogen in the Air to be Used for Plant Growth 12 Sulfate Assimilation Enables the Synthesis of Sulfur Containing Substances 13 Phloem Transport Distributes Photoassimilates to the Various Sites of Consumption and Storage 14 Products of Nitrate Assimilation are Deposited in Plants as Storage Proteins 15 Glycerolipids are Membrane Constituents and Function as Carbon Stores 16 Secondary Metabolites Fulfill Specific Ecological Functions in Plants 17 Large Diversity of Isoprenoids has Multiple Funtions in Plant Metabolism 18 Phenylpropanoids Comprise a Multitude of Plant Secondary Metabolites and Cell Wall Components 19 Multiple Signals Regulate the Growth and Development of Plant Organs and Enable Their Adaptation to Environmental Conditions 20 A Plant Cell has Three Different Genomes 21 Protein Biosynthesis Occurs at Different Sites of a Cell 22 Gene Technology Makes it Possible to Alter Plants to Meet Requirements of Agriculture, Nutrition, and Industry.

Phytochemistry of Medicinal Plants

Phytochemistry of Medicinal Plants
Author: John T. Arnason
Publisher: Springer Science & Business Media
Total Pages: 369
Release: 2013-11-11
Genre: Science
ISBN: 1489917780

Phytochemicals from medicinal plants are receiving ever greater attention in the scientific literature, in medicine, and in the world economy in general. For example, the global value of plant-derived pharmaceuticals will reach $500 billion in the year 2000 in the OECD countries. In the developing countries, over-the-counter remedies and "ethical phytomedicines," which are standardized toxicologically and clinically defined crude drugs, are seen as a promising low cost alternatives in primary health care. The field also has benefited greatly in recent years from the interaction of the study of traditional ethnobotanical knowledge and the application of modem phytochemical analysis and biological activity studies to medicinal plants. The papers on this topic assembled in the present volume were presented at the annual meeting of the Phytochemical Society of North America, held in Mexico City, August 15-19, 1994. This meeting location was chosen at the time of entry of Mexico into the North American Free Trade Agreement as another way to celebrate the closer ties between Mexico, the United States, and Canada. The meeting site was the historic Calinda Geneve Hotel in Mexico City, a most appropriate site to host a group of phytochemists, since it was the address of Russel Marker. Marker lived at the hotel, and his famous papers on steroidal saponins from Dioscorea composita, which launched the birth control pill, bear the address of the hotel.

Phytochemistry of Plants of Genus Piper

Phytochemistry of Plants of Genus Piper
Author: Brijesh Kumar
Publisher: CRC Press
Total Pages: 78
Release: 2020-06-08
Genre: Medical
ISBN: 1000064700

Piper is the representative genus of family Piperaceae. Piper species are pan-tropical in distribution and found in both the hemispheres. As the king of all spices, black pepper, Piper nigrum, led to the global expeditions culminating in the discovery of India and the new world. Piper species have been reported to possess various pharmacological activities such as insecticidal, antibacterial, anti-inflammatory, antiplatelet, anti-hypertensive, antithyroid, antitumor activities and hepatoprotective properties. Botanical authentication of the plants of Piper species is difficult because of the morphological similarity among the species. This book describes ultra-performance liquid chromatography coupled with triple quadrupole electrospray tandem mass spectrometry in multiple reactions monitoring (MRM) mode to study the quantitative variation of thirteen bioactive markers in different plant parts of ten Piper species. Features: Collection of Ayurvedic features and scientific evidence of the most important medicinal plants of Piper species. Describes chemical signatures for identification of Piper species. Provides easy-to-use analytical procedure for quality control of Piper species and its products.

Phytochemistry, the Military and Health

Phytochemistry, the Military and Health
Author: Andrew G. Mtewa
Publisher: Elsevier
Total Pages: 606
Release: 2021-03-02
Genre: Science
ISBN: 0128215569

Phytochemistry, the Military and Health: Phytotoxins and Natural Defenses comes as a response to the gap that there has for so long existed between phytochemistry and survival of both service personnel and civilian communities during and after conflicts. Armed conflicts cause a lot of devastation to communities and should be avoided as much as it can be possible. The devastation is usually evident in service provisions such as Health, Education, Water, and Food among many others. Both service personnel and civilians are affected to various degrees. Facilities usually end up being physically destroyed, with no essential supplies and/or having dysfunctional systems. Going with untreated wounds, communicable and non-communicable diseases for weeks with no medical interventions due to the conflicts, disease burdens heavily weigh down on communities as well as security personnel. To make the situation even more complicated, masses of people are forced to migrate for safety and security reasons, likely going with diseases along wherever they go. In such instances, phytochemicals become handy in providing solutions from first aid, basic analgesia, antimicrobials, and the general improvement of health. Phytochemicals are known to play a major role in the day to day management of diseases and health. There has been much research into their effectiveness as community medicines and as alternatives to conventional drugs. However, the role that phytochemicals play in the military, counterterrorism, and security has been overlooked. Phytochemistry, the Military and Health: Phytotoxins and Natural Defenses discusses the roles that phytochemicals play as friends and foes in the military, including insights aimed to help develop antidotes against phytochemicals and other chemical agents used maliciously as weapons. Filling a gap between drug discovery, security, and emergency medicine, this book describes which plants can be categorized for protection and controls, which can be helpful in times of conflicts and soon after conflicts, in military operations, and those that can be used as deterrents and as emergency medicines. Carefully designed to show the contribution that phytochemicals play in safety and security, this book is useful for researchers, regulators and anyone interested in plant chemistry. Covers the contribution that phytochemicals play in safety and security Contains insights that will help in the development of antidotes against phytochemical and other chemical weapons Categorizes plants in terms of their usefulness as well as the potential security risks they possess

Phytochemistry of Australia's Tropical Rainforest

Phytochemistry of Australia's Tropical Rainforest
Author: Cheryll J. Williams
Publisher: CSIRO PUBLISHING
Total Pages: 1388
Release: 2021-12-01
Genre: Science
ISBN: 1486307604

Rare, unique and irreplaceable – precious native rainforests occupy a precariously small part of Australia while retaining a remarkable level of both biological and chemical diversity unrivalled by any other ecosystem. Australia's ancient history and traditions are intimately intertwined with the rainforest plants that humans have utilised as both food and medicine. Phytochemistry of Australia's Tropical Rainforest is a record of this history and details how our understanding of these plants has led to the discovery of anaesthetics, analgesics, steroids, antimalarials and more. It provides an insight into the habitat, ecology and family associations of hundreds of species and explores their future therapeutic potential, alongside phytochemical studies of the ancient plant lineages. Toxicological evaluations of important poisonous plants are also included. Rainforests provide shelter for unique flora and fauna that are counted among the rarest species on Earth, many of which are illustrated in this book. This comprehensive work is an essential reference for phytochemists, ethnobotanists and those with an interest in rainforests and their medicinal and botanical potential.

Phytochemistry of Plants of Genus Cassia

Phytochemistry of Plants of Genus Cassia
Author: Brijesh Kumar
Publisher: CRC Press
Total Pages: 82
Release: 2021-08-12
Genre: Health & Fitness
ISBN: 1000458091

Cassia is an indigenous plant in Africa, Latin America, Northern Australia and Southeast Asia. Several Cassia species are of high commercial and medicinal significance since they are used as spices and in traditional medicines. Currently plants from genus Cassia is in great demand due to their immense medicinal properties. Cassia species have various pharmacological activities such as antibacterial, analgesic, antiinflammatory, antiarthritic, hepatoprotective, antitumor, antifertility, antifungal, antioxidant, antileishmaniatic, antimicrobial, CNS and hypoglycaemic activitiy. Different class of compounds reported from Cassia species are anthraquinones, phenolics, flavonoids, chromenes, terpenes, proanthocyanidins, coumarins, chromones and lignans. The taxonomy and nomenclature of Cassia species are quite complex. It is very difficult to differentiate them due to their overlapping morphological characters and close similarities. This usually leads to misidentification and misinterpretation of the components. Features: Presents collection of Ayurvedic features and scientific evidence of most important medicinal plants of Cassia species Chemical signatures for identification of Cassia species Easy to use analytical procedure for quality control of Cassia species and its products.