Physiologic And Chemical Basis For Metal Toxicity
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| Author | : B. Venugopal |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 245 |
| Release | : 2013-03-14 |
| Genre | : Medical |
| ISBN | : 1468429523 |
Our purpose is to provide understanding for appropriate use of metals in a technical society. Knowledge of metal toxicity is needed for the preven tion, prediction, diagnosis, and therapy of adverse reactions from excess metals in mammals. Metal Toxicity in Mammals is presented in two volumes. Volume 1, Physiologic and Chemical Basis for Metal Toxic ity, provides the basis for understanding the toxic actions of metals recorded in Volume 2, Chemical Toxicity of Metals and Metalloids. The details and bases for many concepts summarized in Volume I are given, with appropriate references, in Volume 2. Thus, references for specific items in Volume 2 are not generally given in Volume 1. The authors reviewed the known toxicity of several heavy metals in anticipation of their use as multinutrient markers for NASA. As more and more metals were considered, the need for a complete review became obvious. This treatise supplants onerous searches of metal-toxicity litera ture up to 1975 and reviews the toxicity of all the metals of the periodic table on the basis of available relevant data. Books on pharmacological, nutritional, medical, veterinary, or industrial toxicity contain information about selected metals. More complete data about metals of public concern, such as mercury, lead, and cadmium, may be found in numerous books and reviews. The reader should refer to general texts and basic reference works, when specific references are not given, for general information.
| Author | : Jan Aaseth |
| Publisher | : Academic Press |
| Total Pages | : 390 |
| Release | : 2016-04-18 |
| Genre | : Medical |
| ISBN | : 0128030739 |
Chelation Therapy in the Treatment of Metal Intoxication presents a practical guide to the use of chelation therapy, from its basic chemistry, to available chelating antidotes, and the application of chelating agents. Several metals have long been known to be toxic to humans, and continue to pose great difficulty to treat. These challenges pose particular problems in industrial settings, with lead smelting known to be associated with hemopoietic alterations and paralyses, and the inhalation of mercury vapor in mercury mining being extremely detrimental to the central nervous system. Clinical experience has demonstrated that acute and chronic human intoxications with a range of metals can be treated efficiently by administration of chelating agents. Chelation Therapy in the Treatment of Metal Intoxication describes the chemical and biological principles of chelation in the treatment of these toxic metal compounds, including new chelators such as meso-2,3-dimercaptosuccinic acid (DMSA) and D,L-2,3-dimercapto-1-propanesulfonic acid (DMPS). - Presents all the current findings on the potential for chelation as a therapy for metal intoxication - Presents practical guidelines for selecting the most appropriate chelating agent - Includes coverage on radionuclide exposure and metal storage diseases - Describes the chemical and biological principles of chelation in the treatment of toxic metal compounds
| Author | : Ozgur Karcioglu |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 130 |
| Release | : 2019-06-19 |
| Genre | : Medical |
| ISBN | : 1838807853 |
Over 400 years ago, Swiss alchemist and physician Paracelsus (1493-1541) cited: "All substances are poisons; there is none that is not a poison. The right dose differentiates a poison from a remedy." This is often condensed to: "The dose makes the poison." So, why are we overtly anxious about intoxications?In fact, poisons became a global problem with the industrial revolution. Pesticides, asbestos, occupational chemicals, air pollution, and heavy metal toxicity maintain high priority worldwide, especially in developing countries. Children between 0 and 5 years old are the most vulnerable to both acute and chronic poisonings, while older adults suffer from the chronic effects of chemicals. This book aims to raise awareness about the challenges of poisons, to help clinicians understand current issues in toxicology.
| Author | : Gaspar Banfalvi |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 348 |
| Release | : 2011-03-02 |
| Genre | : Medical |
| ISBN | : 9400704283 |
The term “heavy metals” is used as a group name of toxic metals and metalloids (semimetals) causing contaminations and ecotoxicity. In strict chemical sense the density of heavy metals is higher than 5 g/cm3. From biological point of view as microelements they can be divided into two major groups. a. For their physiological function organisms and cells require essential microelements such as iron, chromium (III), cobalt, copper, manganese, molidenium, zinc. b. The other group of heavy metals is toxic to the health or environment. Of highest concern are the emissions of As, Cd, Co, Cu, Hg, Mn, Ni, Pb, Sn, Tl. The toxicity of heavy metals is well known at organizational level, while less attention has been paid to their cellular effects. This book describes the toxicity of heavy metals on microorganisms, yeast, plant and animal cells. Other chapters of the book deal with their genotoxic, mutagenic and carcinogenic effects. The toxicity of several metals touch upon the aspects of environmental hazard, ecosystems and human health. Among the cellular responses of heavy metals irregularities in cellular mechanisms such as gene expression, protein folding, stress signaling pathways are among the most important ones. The final chapters deal with biosensors and removal of heavy metals. As everybody is eating, drinking and exposed to heavy metals on a daily basis, the spirit of the book will attract a wide audience.
| Author | : Thomas D. Luckey |
| Publisher | : |
| Total Pages | : 256 |
| Release | : 1977 |
| Genre | : Mammals |
| ISBN | : |
| Author | : Robert R Crichton |
| Publisher | : Royal Society of Chemistry |
| Total Pages | : 336 |
| Release | : 2016-10-18 |
| Genre | : Science |
| ISBN | : 1782623892 |
Metal chelators are emerging as versatile tool with many medical applications. Their versatility allows them to be used in chelation therapy for treating diseases caused by toxic and heavy metal poisoning, chelating agents are capable of binding to toxic metal ions to form complex structures which are easily excreted from the body removing them from intracellular or extracellular spaces. In addition, metal chelators can also be applied as contrast agents in MRI scanning. Metal Chelation in Medicine provides a clear and timely perspective on the role of chelating agents in the management of metal intoxications and storage diseases. Written by leaders in the field of chelators, this publication is at the cutting-edge of the subject. It covers a broad range of topics such as the use of metal chelators in non-invasive assessment of brain iron overload, and the treatment of systemic iron overload and neurodegenerative diseases. As such it is particularly valuable to clinicians treating metal poisonings and metal storage diseases. However, it is also a useful text for researchers, industry professionals and university students with a specific interest in medicinal chemistry, chelation, metal ions, imaging and non-invasive techniques.
| Author | : Sanjay K. Sharma |
| Publisher | : Royal Society of Chemistry |
| Total Pages | : 382 |
| Release | : 2014 |
| Genre | : Medical |
| ISBN | : 1849738858 |
This book highlights the latest research on dissolved heavy metals in drinking water and their removal.
| Author | : |
| Publisher | : Academic Press |
| Total Pages | : 520 |
| Release | : 2011-08-11 |
| Genre | : Technology & Engineering |
| ISBN | : 9780123786364 |
Homeostasis and Toxicology of Essential Metals synthesizes the explosion of new information on the molecular, cellular, and organismal handling of metals in fish in the past 15 years. These elements are no longer viewed by fish physiologists as "heavy metals" that kill fish by suffocation, but rather as interesting moieties that enter and leave fish by specific pathways, which are subject to physiological regulation. The metals featured in this volume are those about which there has been most public and scientific concern, and therefore are those most widely studied by fish researchers. Metals such as Cu, Zn, Fe, Ni, Co, Se, Mo and Cr are either proven to be or are strongly suspected to be essential in trace amounts, yet are toxic in higher doses. The companion volume, Homeostasis and Toxicology of Non-Essential Metals, Volume 31B, covers metals that have no known nutritive function in fish at present, but which are toxic at fairly low levels, such as Ag, Al, Cd, Pb, Hg, As, Sr, and U. In addition, three chapters in Volumes 31A and 31B on Basic Principles (Chapter 1, 31A), Field Studies and Ecological Integration (Chapter 9, 31A) and Modeling the Physiology and Toxicology of Metals (Chapter 9, 31B) act as integrative summaries and make these two volumes a vital set for readers. All major essential metals of interest are covered in metal-specific chapters Each metal-specific chapter is written by fish physiologists/toxicologists who are recognized authorities for that metal A common format is featured throughout this two volume edition
| Author | : N. W. Lepp |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 360 |
| Release | : 2012-12-06 |
| Genre | : Science |
| ISBN | : 9401173397 |
Trace metals occur as natural constituents of the earth's crust, and are ever present constituents of soils, natural waters and living matter. The biological significance of this disparate assemblage of elements has gradually been uncovered during the twentieth century; the resultant picture is one of ever-increasing complexity. Several of these elements have been demonstrated to be essential to the functions of living organisms, others appear to only interact with living matter in a toxic manner, whilst an ever-decreasing number do not fall conveniently into either category. When the interactions between trace metals and plants are considered, one must take full account of the known chemical properties of each element. Consideration must be given to differences in chemical reactivity, solubility and to interactions with other inorganic and organic molecules. A clear understanding of the basic chemical properties of an element of interest is an essential pre-requisite to any subsequent consideration of its biological significance. Due consideration to basic chemical considerations is a theme which runs through the collection of chapters in both volumes.
| Author | : Muharrem Ince |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 232 |
| Release | : 2020-07-29 |
| Genre | : Medical |
| ISBN | : 178984696X |
Biochemical Toxicology - Heavy Metals and Nanomaterials provides an overview of biochemical contamination, nanomaterials and toxic metals, and measurement techniques. It explains and clarifies important studies and compares and develops new and groundbreaking measurement techniques in the fields of organic and inorganic pollution and nanoscience. It is highly recommended for professionals and readers interested in the environment and human health.
