Physics And Technology Of Hyperthermia
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| Author | : S.B. Field |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 672 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 9400935978 |
In the 1960s a firm rationale was developed for using raised temperatures to treat malignant disease and there has been a continuous expansion of the field ever since. However, a major limitation exists in our ability to heat human tumours, especially those sited deep in the body, with a reasonable degree of temperature uniformity. This problem has resulted in engineers and physicists collaborating closely with biologists and clinicians towards the common goal of developing and testing the clinical potential of this exciting treatment modality. The aim of the physicist and engineer is to develop acceptible methods of heating tumQur masses in as many sites as possible to therapeutic temperatures avoiding excessive heating of normal structures and, at the same time, obtaining the temperature distribution throughout the heated volume. The problem is magnified by both the theoretical and technical limitations of heating methods and devices. Moreover, the modelling of external deposition of energy in tissue and knowledge of tissue perfusion are ill-defined. To this must be added the conceptual difficulty of defining a thermal dose. The NATO course was designed to provide a basis for the integration of physics and technology relevant to the development of hyperthermia. There were 48 lectures covering the theoretical and practical aspects of system design and assessment, including, as far as possible, all the techniques of current interest and importance in the field.
| Author | : M.Heinrich Seegenschmiedt |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 479 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 3642578586 |
Hyperthermia has been found to be of great benefit in combination with radiation therapy or chemotherapy in the management of patients with difficult and com plicated tumor problems. It has been demonstrated to increase the efficacy, of ionising radiation when used locally but also has been of help in combination with systemic chemotherapy where hyperthermia is carried out to the total body. Problems remain with regard to maximizing the effects of hyperthermia as in fluenced by blood flow, heat loss, etc. The present volume defines the current knowledge relative to hyperthermia with radiation therapy and/or chemotherapy, giving a comprehensive overview of its use in cancer management. Philadelphia/Hamburg, June 1995 L.W. BRADY H.-P. HEILMANN Preface In an attempt to overcome tumor resistance, hypoxia, or unfavorable tumor condi tions, oncological research has come to focus on gene therapy, immunotherapy, new cytotoxic agents, and increasingly sophisticated radiotherapy. Radiation research has been directed towards heavy particle therapy and modification of the radiation response by either protecting or sensitizing agents. Improved dose localization using rotational or conformal strategies has also been implemented. Recently, changes in radiation fractionation schedules have shown promise of better results. Hyperthermia in cancer therapy can be viewed similarly as another means to increase the sensitivity of tumors to radio- and chemotherapy.
| Author | : Eduardo Moros |
| Publisher | : Taylor & Francis |
| Total Pages | : 375 |
| Release | : 2016-04-19 |
| Genre | : Medical |
| ISBN | : 1439848920 |
The field of thermal therapy has been growing tenaciously in the last few decades. The application of heat to living tissues, from mild hyperthermia to high-temperature thermal ablation, has produced a host of well-documented genetic, cellular, and physiological responses that are being researched intensely for medical applications, particularly fo
| Author | : Devashish Shrivastava |
| Publisher | : John Wiley & Sons |
| Total Pages | : 897 |
| Release | : 2018-07-02 |
| Genre | : Science |
| ISBN | : 1119127300 |
An authoritative guide to theory and applications of heat transfer in humans Theory and Applications of Heat Transfer in Humans 2V Set offers a reference to the field of heating and cooling of tissue, and associated damage. The author—a noted expert in the field—presents, in this book, the fundamental physics and physiology related to the field, along with some of the recent applications, all in one place, in such a way as to enable and enrich both beginner and advanced readers. The book provides a basic framework that can be used to obtain ‘decent’ estimates of tissue temperatures for various applications involving tissue heating and/or cooling, and also presents ways to further develop more complex methods, if needed, to obtain more accurate results. The book is arranged in three sections: The first section, named ‘Physics’, presents fundamental mathematical frameworks that can be used as is or combined together forming more complex tools to determine tissue temperatures; the second section, named ‘Physiology’, presents ideas and data that provide the basis for the physiological assumptions needed to develop successful mathematical tools; and finally, the third section, named ‘Applications’, presents examples of how the marriage of the first two sections are used to solve problems of today and tomorrow. This important text is the vital resource that: Offers a reference book in the field of heating and cooling of tissue, and associated damage. Provides a comprehensive theoretical and experimental basis with biomedical applications Shows how to develop and implement both, simple and complex mathematical models to predict tissue temperatures Includes simple examples and results so readers can use those results directly or adapt them for their applications Designed for students, engineers, and other professionals, a comprehensive text to the field of heating and cooling of tissue that includes proven theories with applications. The author reveals how to develop simple and complex mathematical models, to predict tissue heating and/or cooling, and associated damage.
| Author | : Sid M. Becker |
| Publisher | : Academic Press |
| Total Pages | : 428 |
| Release | : 2014-12-31 |
| Genre | : Science |
| ISBN | : 0124079008 |
Heat Transfer and Fluid Flow in Biological Processes covers emerging areas in fluid flow and heat transfer relevant to biosystems and medical technology. This book uses an interdisciplinary approach to provide a comprehensive prospective on biofluid mechanics and heat transfer advances and includes reviews of the most recent methods in modeling of flows in biological media, such as CFD. Written by internationally recognized researchers in the field, each chapter provides a strong introductory section that is useful to both readers currently in the field and readers interested in learning more about these areas. Heat Transfer and Fluid Flow in Biological Processes is an indispensable reference for professors, graduate students, professionals, and clinical researchers in the fields of biology, biomedical engineering, chemistry and medicine working on applications of fluid flow, heat transfer, and transport phenomena in biomedical technology. - Provides a wide range of biological and clinical applications of fluid flow and heat transfer in biomedical technology - Covers topics such as electrokinetic transport, electroporation of cells and tissue dialysis, inert solute transport (insulin), thermal ablation of cancerous tissue, respiratory therapies, and associated medical technologies - Reviews the most recent advances in modeling techniques
| Author | : Urs Häfeli |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 618 |
| Release | : 2013-11-11 |
| Genre | : Science |
| ISBN | : 1475764820 |
The discovery of uniform latex particles by polymer chemists of the Dow Chemical Company nearly 50 years ago opened up new exciting fields for scientists and physicians and established many new biomedical applications. Many in vitro diagnostic tests such as the latex agglutination tests, analytical cell and phagocytosis tests have since become rou tine. They were all developed on the basis of small particles bound to biological active molecules and fluorescent and radioactive markers. Further developments are ongoing, with the focus now shifted to applications of polymer particles in the controlled and di rected transport of drugs in living systems. Four important factors make microspheres interesting for in vivo applications: First, biocompatible polymer particles can be used to transport known amounts of drug and re lease them in a controlled fashion. Second, particles can be made of materials which bio degrade in living organisms without doing any harm. Third, particles with modified surfaces are able to avoid rapid capture by the reticuloendothelial system and therefore en hance their blood circulation time. Fourth, combining particles with specific molecules may allow organ-directed targeting.
| Author | : Raluca Maria Fratila |
| Publisher | : Elsevier |
| Total Pages | : 386 |
| Release | : 2018-11-30 |
| Genre | : Science |
| ISBN | : 0128139293 |
Nanomaterials for Magnetic and Optical Hyperthermia Applications focuses on the design, fabrication and characterization of nanomaterials (magnetic, gold and hybrid magnetic-gold nanoparticles) for in vitro and in vivo hyperthermia applications, both as standalone and adjuvant therapy in combination with chemotherapy. The book explores the potential for more effective cancer therapy solutions through the synergistic use of nanostructured materials as magnetic and optical hyperthermia agents and targeted drug delivery vehicles, while also discussing the challenges related to their toxicity, regulatory and translational aspects. In particular, the book focuses on the design, synthesis, biofunctionalization and characterization of nanomaterials employed for magnetic and optical hyperthermia. This book will be an important reference resource for scientists working in the areas of biomaterials and biomedicine seeking to learn about the potential of nanomaterials to provide hyperthermia solutions. - Explores the design of efficient nanomaterials for hyperthermia applications, allowing readers to make informed materials selection decisions - Discusses the biofunctionalization of a range of nanomaterials and their interaction with living systems - Provides an overview of the current clinical applications of nanomaterials in hyperthermia treatment
| Author | : Punit Prakash |
| Publisher | : Elsevier |
| Total Pages | : 422 |
| Release | : 2021-12-09 |
| Genre | : Technology & Engineering |
| ISBN | : 0128205946 |
Principles and Technologies for Electromagnetic Energy Based Therapies covers the theoretical foundations of electromagnetic-energy based therapies, principles for design of practical devices and systems, techniques for in vitro and in vivo testing of devices, and clinical application examples of contemporary therapies employing non-ionizing electromagnetic energy. The book provides in-depth coverage of: pulsed electric fields, radiofrequency heating systems, tumor treating fields, and microwave heating technology. Devices and systems for electrical stimulation of neural and cardiac issue are covered as well. Lastly, the book describes and discusses issues that are relevant to engineers who develop and translate these technologies to clinical applications. Readers can access information on incorporation of preclinical testing, clinical studies and IP protection in this book, along with in-depth technical background for engineers on electromagnetic phenomena within the human body and selected therapies. It covers both engineering and biological/medical materials and gives a full perspective on electromagnetics therapies. Unique features include content on tumor treating fields and the development and translation of biomedical devices. Provides in-depth technical background on electromagnetic energy-based therapies, along with real world examples on how to design devices and systems for delivering electromagnetic energy-based therapies Includes guidance on issues that are relevant for translating the technology to the market, such as intellectual property, regulatory issues, and preclinical testing Companion site includes COMSOL models, MATLAB code, and lab protocols
| Author | : Lawrence Davis |
| Publisher | : |
| Total Pages | : 590 |
| Release | : 201? |
| Genre | : Physics |
| ISBN | : |
"Body Physics was designed to meet the objectives of a one-term high school or freshman level course in physical science, typically designed to provide non-science majors and undeclared students with exposure to the most basic principles in physics while fulfilling a science-with-lab core requirement. The content level is aimed at students taking their first college science course, whether or not they are planning to major in science. However, with minor supplementation by other resources, such as OpenStax College Physics, this textbook could easily be used as the primary resource in 200-level introductory courses. Chapters that may be more appropriate for physics courses than for general science courses are noted with an asterisk symbol (*). Of course this textbook could be used to supplement other primary resources in any physics course covering mechanics and thermodynamics"--Textbook Web page.
| Author | : G. Puddu |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 266 |
| Release | : 2013-03-09 |
| Genre | : Medical |
| ISBN | : 3662043696 |
Written by an international board of experts, this comprehensive text provides an in-depth review on the treatment and rehabilitation of the most common sports-related injuries according to the latest scientific developments in functional rehabilitation and the most clinically relevant features of pathophysiology of sports lesions. The management of acute and overuse sports lesions are classified by body area -- spine, upper and lower extremity.
