Phosphoinositide 3 Kinase Signalling Pathway The Key To Cell Proliferation And Death
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| Author | : Eric Wing-fai Lam |
| Publisher | : World Scientific Publishing Company |
| Total Pages | : 253 |
| Release | : 2006-06-08 |
| Genre | : Science |
| ISBN | : 1911299204 |
Aimed at advanced undergraduates, postgraduates and researchers, this important textbook provides a detailed description of the structure and mechanisms of phosphoinositide 3-kinase (PI3Ks) signalling of all classes, with focus on the cellular context of PI3K activity, including its relevance to normal tissue and diseased states.This book contains a general review chapter detailing the mechanisms of cell proliferation and apoptosis, which are two of the main cellular targets of PI3K signalling. In addition, it provides a detailed description of the role of PI3K on the regulation of FOXO proteins, which are now becoming one of the most closely studied and important proteins in the regulation of cell death, cell proliferation and senescence./a
| Author | : Eric W.-F. Lam |
| Publisher | : |
| Total Pages | : 238 |
| Release | : 2006 |
| Genre | : Science |
| ISBN | : 9781860946264 |
Aimed at advanced undergraduates, postgraduates and researchers, this important textbook provides a detailed description of the structure and mechanisms of phosphoinositide 3-kinase (PI3Ks) signalling of all classes, with focus on the cellular context of PI3K activity, including its relevance to normal tissue and diseased states. This book contains a general review chapter detailing the mechanisms of cell proliferation and apoptosis, which are two of the main cellular targets of PI3K signalling. In addition, it provides a detailed description of the role of PI3K on the regulation of FOXO proteins, which are now becoming one of the most closely studied and important proteins in the regulation of cell death, cell proliferation and senescence. Contents: Introduction (E W-F Lam); Cell Proliferation and Cell Death; In Vivo Roles of Cell Cycle and Apoptosis Regulators; The Role of Phosphoinositide 3-Kinase in Proliferation and Apoptosis (A Sunters & E W-F Lam); Phosphoinositide 3-Kinase Signalling Pathway; Class IA PI3K Enzymes; Class IB PI3K Enzymes; Class II PI3K Enzymes; Class III PI3K Enzymes; Expression of PI3K Enzymes; 3-Phosphoinositide Binding Domains; Downstream Targets of 3-Phosphoinositide; Manipulation of PI3K Enzyme Expression; Biological Role of PI3K Signalling Pathway; Phosphoinositide Phosphatases; The Role of the PI3K Pathway in Disease (J Domin); PI3K Signalling to Cell Survival and Proliferation; Molecules Directly Regulated by D3 Lipids; Genetic Studies of PI3K Function in Model Organisms; Molecules Downstream of PI3K and D3 Lipids; PI3K Regulation of Cell Survival; Signalling from PI3K to Cell Proliferation; Alterations of PI3K and Its Pathways in Cancer; Cancer Therapeutics (P Brennan); FOXO Transcription Factors; Forkhead Transcription Factors; FOXO Transcription Factors; Signalling to FOXO Proteins; Cellular Relocation Mechanism; FOXO Protein Processing; Transcriptional Activity of FoxO Proteins; Functions of FOXO in Vivo; FOXO Targets and Function; FOXO Proteins in Transformation and Diseases (S Fernandez de Mattos et al.). Key Features Provides a clear and well-organized review of PI3K signalling garnered from an exhaustive review of the available literature Readership: Undergraduates, postgraduates, academic researchers, clinicians and scientists working in industry.
| Author | : Christian Rommel |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 308 |
| Release | : 2010-10-17 |
| Genre | : Medical |
| ISBN | : 3642148166 |
PI3K has become a very intense area of research, with over 2000 publications on PI3K in PubMed for 2009 alone. The expectations for a therapeutic impact of intervention with PI3K activity are high, and progress in the clinical arena is being monitored by many. However, targeted therapies almost invariably encounter roadblocks, often exposing unresolved questions in the basic understanding of the target
| Author | : Christian Rommel |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 311 |
| Release | : 2010-10-17 |
| Genre | : Medical |
| ISBN | : 364213663X |
From humble beginnings over 25 years ago as a lipid kinase activity associated with certain oncoproteins, PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of drug development in cancer, immunity and thrombosis, with the first clinical trials of PI3K pathway inhibitors now in progress. Here we give a brief overview of some key discoveries in the PI3K area and their impact, and include thoughts on the current state of the field, and where it could go from here
| Author | : Klaus Okkenhaug |
| Publisher | : Frontiers Media SA |
| Total Pages | : 140 |
| Release | : 2015-03-05 |
| Genre | : Immunologic diseases. Allergy |
| ISBN | : 2889194191 |
The PI3Ks control many key functions in immune cells. PI3Ks phosphorylate PtdIns(4,5)P2 to yield PtdIns(3,4,5)P3. Initially, PI3K inhibitors such as Wortmannin, LY294002 and Rapamycin were used to establish a central role for Pi3K pathway in immune cells. Considerable progress in understanding the role of this pathway in cells of the immune system has been made in recent years, starting with analysis of various PI3K and Pten knockout mice and subsequently mTOR and Foxo knockout mice. Together, these experiments have revealed how PI3Ks control B cell and T cell development, T helper cell differentiation, regulatory T cell development and function, B cell and T cell trafficking, immunoglobulin class switching and much, much more. The PI3Kd inhibitor idelalisib has recently been approved for the treatment of B cell lymphoma. Clinical trials of other PI3K inhibitors in autoimmune and inflammatory diseases are also in progress. This is an opportune time to consider a Research Topic considering when what we have learned about the PI3K signalling module in lymphocyte biology and how this is making an impact on clinical immunology and haematology.
| Author | : Christian Rommel |
| Publisher | : Springer |
| Total Pages | : 306 |
| Release | : 2010-10-01 |
| Genre | : Medical |
| ISBN | : 9783642148156 |
PI3K has become a very intense area of research, with over 2000 publications on PI3K in PubMed for 2009 alone. The expectations for a therapeutic impact of intervention with PI3K activity are high, and progress in the clinical arena is being monitored by many. However, targeted therapies almost invariably encounter roadblocks, often exposing unresolved questions in the basic understanding of the target
| Author | : Ayse Basak Engin |
| Publisher | : Springer Nature |
| Total Pages | : 415 |
| Release | : 2021-02-04 |
| Genre | : Medical |
| ISBN | : 3030498441 |
Protein phosphorylation via protein kinases is an inevitable process that alters physiological and pathological functions of the cells. Thus, protein kinases play key roles in the regulation of cell life or death decisions. Protein kinases are frequently a driving factor in a variety of human diseases including aging and cellular senescence, immune system and endothelial dysfunctions, cancers, insulin resistance, cholestasis and neurodegenerative diseases, as well as bacterial resistance in persistent infections. Recent developments in quantitative proteomics provide important opinions on kinase inhibitor selectivity and their modes of action in the biological context. Protein Kinase-mediated Decisions Between Life and Death aims to have the reader catch insights about up-to-date opinions on “Protein Kinases” related pathways that threaten human health and life. As “Protein Kinases” are related to many health problems, clinicians, basic science researchers and students need this information. Chapter “Signal Transduction in Immune Cells and Protein Kinases” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
| Author | : Christian Rommel |
| Publisher | : Springer |
| Total Pages | : 310 |
| Release | : 2012-11-07 |
| Genre | : Medical |
| ISBN | : 9783642265228 |
From humble beginnings over 25 years ago as a lipid kinase activity associated with certain oncoproteins, PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of drug development in cancer, immunity and thrombosis, with the first clinical trials of PI3K pathway inhibitors now in progress. Here we give a brief overview of some key discoveries in the PI3K area and their impact, and include thoughts on the current state of the field, and where it could go from here
| Author | : M. A. Hayat |
| Publisher | : Academic Press |
| Total Pages | : 431 |
| Release | : 2016-12-28 |
| Genre | : Medical |
| ISBN | : 0128094273 |
Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is an eleven volume series that discusses in detail all aspects of autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. This series discusses the characterization of autophagosome-enriched vaccines and its efficacy in cancer immunotherapy. Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis. Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward-thinking, these books offer a valuable guide to cellular processes while also inciting researchers to explore their potentially important connections. - Presents the most advanced information regarding the role of the autophagic system in life and death - Examines whether autophagy acts fundamentally as a cell survivor or cell death pathway or both - Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation - Features recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, including atherosclerosis and CNS tumors, and their development and treatment - Includes chapters authored by leaders in the field around the globe—the broadest, most expert coverage available
| Author | : |
| Publisher | : |
| Total Pages | : |
| Release | : 2004 |
| Genre | : |
| ISBN | : |
Cells control their behavior by maintaining a balance between signal transduction pathways. The disruption of this balance has been implicated in the evolution of normal cells into cancer cells. People expected to inhibit or activate a specific pathway to achieve the cure of cancer. However, signaling pathways are usually woven together through so-called cross-talk interaction and it is almost impossible to design a drug specifically targeting a pathway. Thus, the fundamental understanding of the intracellular signaling processes is important on medicine and biotechnology. Platelet-derived growth factor (PDGF) is a potent stimulator of cell growth and motility. PDGF-induced phosphoinositide 3-kinase (PI 3-kinase)/Akt and Ras/extracellular signal-regulated kinase (Erk) pathways are thought to play central roles in the regulation of cell survival and proliferation. Crosstalk between PI 3-kinase/Akt and Ras/Erk pathways has provided important hints for how PDGF receptor activation may control cellular function. The apparently contradictory findings among recently studies suggest that the cross-talk mechanisms are not fully understood. In this study, we aim to systematically analyze this signaling network, comprised of Ras/Erk and PI 3-kinase/Akt pathways, stimulated by PDGF. Molecular level control over the signaling network, through genetic and pharmacological intervention, will allow these complex regulatory interaction to be isolated. We assessed the phosphorylation of Akt and Erk as the outputs of PI 3-kinase/Akt and Ras/Erk pathways respectively, and detected DNA synthesis and cell numbers to analyze the effect of these two pathways on the resulting life and death decisions. Accumulating evidence has demonstrated that differences in the strength of stimulus, and the duration and magnitude of activity of signal molecules, determine signaling specificity. We offer a quantitative approach -- crosstalk titration -- to analyze the effect of our intervention s.
