Pharmacology Of Opioid Peptides
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| Author | : L F Tseong |
| Publisher | : CRC Press |
| Total Pages | : 542 |
| Release | : 1995-09-01 |
| Genre | : Medical |
| ISBN | : 9783718656325 |
This book is being published at a time when opioid receptors have recently been cloned. The structural characteristics of opioid receptors and the recent advances in their molecular cloning and expression are explicated. Connecting these cloned opioid receptors with the pharmacology of opioid receptor actions is of particular importance. The use of antisense oligodeoxynucleotides to opioid receptors to elucidate the neural mechanisms of opioid action is detailed. As analgesia is one of the most important clinical functions for opioids and opioid peptides, this book concentrates on the detailed mechanisms of action of opioids and opioid peptides for the production of analgesia. The significant pharmacologic actions of opioids and opioid peptides in gastrointestinal function, immune function, cardiovascular and respiratory regulation, addiction and the cellular mechanisms involved in tolerance and dependence of opioids are also described. The book will be of interest both to researchers investigating the neural mechanisms of the pharmacologic and physiologic functions of the endogenous opioid system and to clinicians who are involved in pain management and assessment.
| Author | : Catherine F. Stannard |
| Publisher | : Oxford University Press |
| Total Pages | : 121 |
| Release | : 2013-03-21 |
| Genre | : Medical |
| ISBN | : 0199678073 |
This pocketbook summarizes the recent developments in this important and controversial aspect of pain management, looking at the benefits and adverse effects of opioids in non-cancer pain.
| Author | : Mariana Spetea |
| Publisher | : MDPI |
| Total Pages | : 358 |
| Release | : 2020-12-18 |
| Genre | : Medical |
| ISBN | : 3036500464 |
The interest in opioids such as morphine, the prototypical opioid ligand, has been maintained through the years. The identification of endogenous opioids and their receptors (mu, delta, kappa, and nociceptin), molecular cloning, and the elucidation of the crystal structures of opioid receptors represent key milestones in opioid research. The opioid system modulates numerous pharmacological responses, with therapeutic (i.e., analgesia) and detrimental side effects (i.e., addiction). The medical use and misuse of opioids have dramatically increased, leading to the 21st century opioid crisis. This book presents recent developments in opioid drug discovery, specifically in the medicinal chemistry and pharmacology of new ligands targeting the opioid receptors as effective and safe therapeutics for human diseases. Furthermore, it draws a special attention to advancing concepts and strategies in opioid drug discovery to mitigate opioid liabilities. The diversity among the discussed topics is a testimony to the complexity of the opioid system, which results from the expression, regulation, and functional role of ligands and receptors. The array of multidisciplinary research areas illustrates the rapidly developing basic research and translational activities in opioid drug discovery. This book will serve as a useful reference while also stimulating continued research in the chemistry and pharmacology of opioids and their receptors, with the prospect of developing improved therapies for human diseases, but also improving health and quality of life in general.
| Author | : Alex S. Evers |
| Publisher | : Cambridge University Press |
| Total Pages | : 2902 |
| Release | : 2011-03-10 |
| Genre | : Medical |
| ISBN | : 1139497022 |
In recent years our understanding of molecular mechanisms of drug action and interindividual variability in drug response has grown enormously. Meanwhile, the practice of anesthesiology has expanded to the preoperative environment and numerous locations outside the OR. Anesthetic Pharmacology: Basic Principles and Clinical Practice, 2nd edition, is an outstanding therapeutic resource in anesthesia and critical care: Section 1 introduces the principles of drug action, Section 2 presents the molecular, cellular and integrated physiology of the target organ/functional system and Section 3 reviews the pharmacology and toxicology of anesthetic drugs. The new Section 4, Therapeutics of Clinical Practice, provides integrated and comparative pharmacology and the practical application of drugs in daily clinical practice. Edited by three highly acclaimed academic anesthetic pharmacologists, with contributions from an international team of experts, and illustrated in full colour, this is a sophisticated, user-friendly resource for all practitioners providing care in the perioperative period.
| Author | : E. Carstens |
| Publisher | : CRC Press |
| Total Pages | : 482 |
| Release | : 2014-02-25 |
| Genre | : Science |
| ISBN | : 1466505435 |
Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain. Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer. Composed of contributions from distinguished researchers around the world, the book explores topics such as: Neuropathic itch Peripheral neuronal mechanism of itch The role of PAR-2 in neuroimmune communication and itch Mrgprs as itch receptors The role of interleukin-31 and oncostatin M in itch and neuroimmune communication Spinal coding of itch and pain Spinal microcircuits and the regulation of itch Examining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.
| Author | : |
| Publisher | : Academic Press |
| Total Pages | : 0 |
| Release | : 2018-10-12 |
| Genre | : Medical |
| ISBN | : 9780444641670 |
The Opioid System as the Brain's Interface between Cognition and Motivation, Volume 239, focuses on the opioid system as the interface between the brain's cognitive and motivational systems. As the opioid system is widely distributed through the brain, particularly in areas implicated in cognition (hippocampus, prefrontal cortex, claustrum, thalamus) and motivation (hypothalamus, amygdala, pontine nuclei, periaqueductal gray and medulla), this book provides chapters that address ongoing research on topics such as the Brain's cognitive system, the Brain's motivational system, Antidepressant prescription patterns, Antidepressant-like effects of opioid receptor modulators, the Behavioral effects of antidepressant and anxiolytic drugs, and more.
| Author | : James S. Gaynor |
| Publisher | : Elsevier Health Sciences |
| Total Pages | : 661 |
| Release | : 2008-01-29 |
| Genre | : Medical |
| ISBN | : 0323062903 |
You can trust this user-friendly guide to help you meet the increasing need for effective pain management in the animals you treat. It provides instant access to clinically relevant information on pain assessment, pharmaceutical and non-pharmaceutical treatment options, guidelines for managing acute and chronic pain, and unique aspects of pain management in dogs, cats, horses, cattle, birds, reptiles, ferrets, and rabbits. User-friendly format helps you quickly and easily find essential pain management information. Helpful boxes and tables provide at-a-glance access to pharmacologic protocols and clinical applications, including dosages, indications, contraindications, and side effects. Complementary and alternative treatment strategies are included throughout to assist you in using the latest non-pharmacological pain interventions. Case studies clearly illustrate the practical applications of key concepts in the clinical setting and help you sharpen your pain assessment and management skills. New contributors — many of the most respected experts in the field — share their insights and experiences to bring you the most current thinking in this ever-changing discipline. Completely revised and updated content throughout ensures you are using the best and most current information available on analgesic drugs and pain management techniques. An expanded chapter on Pain Management in Horses and Cattle explores the latest advances in treating this group of animals. Eight new chapters offer cutting-edge coverage of hot topics in the field, including: Pain Management in the Cat Pain Management for the Pet Bird Clinical Approaches to Analgesia in Reptiles Clinical Approaches to Analgesia in Ferrets and Rabbits Physical Therapy and Rehabilitation in Dogs Rehabilitation Methods and Modalities for the Cat Quality of Life Issues Hospice and Palliative Care
| Author | : Colin Pinnock |
| Publisher | : Cambridge University Press |
| Total Pages | : 990 |
| Release | : 2002-12 |
| Genre | : Medical |
| ISBN | : 9780521690799 |
The second edition of Fundamentals of Anaesthesia builds upon the success of the first edition, and encapsulates the modern practice of anaesthesia in a single volume. Written and edited by a team of expert contributors, it provides a comprehensive but easily readable account of all of the information required by the FRCA Primary examination candidate and has been expanded to include more detail on all topics and to include new topics now covered in the examination. As with the previous edition, presentation of information is clear and concise, with the use of lists, tables, summary boxes and line illustrations where necessary to highlight important information and aid the understanding of complex topics. Great care has been taken to ensure an unrivalled consistency of style and presentation throughout.
| Author | : Antonio Noronha |
| Publisher | : Elsevier |
| Total Pages | : 573 |
| Release | : 2014-05-02 |
| Genre | : Science |
| ISBN | : 0124071554 |
Recent scientific advances have provided substantial information on the brain circuits and pathways relevant to various aspects of dependence. Neurobiology of Alcohol Dependence highlights the most recent data at the molecular, cellular, neurocircuitry, and behavioral levels, fostering an understanding how neuroplasticity and neuroadaptation occur, and how different neural pathways and neurocircuits contribute to dependence. - Highlights recent advances in understanding alcohol addiction from molecular, cellular, neurocircuitry, and behavioral levels - Integrates several emerging areas of research and discusses the application of novel research techniques to the understanding of alcohol dependence - Chapters authored by leaders in the field around the globe — the broadest, most expert coverage available
| Author | : Peter Illes |
| Publisher | : John Wiley & Sons |
| Total Pages | : 560 |
| Release | : 1988 |
| Genre | : Medical |
| ISBN | : |
