Pharmacological Regulation Of Gene Expression In The Cns Towards An Understanding Of Basal Ganglial Functions 1996
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Author | : Kalpana Merchant |
Publisher | : CRC Press |
Total Pages | : 375 |
Release | : 2017-11-22 |
Genre | : Science |
ISBN | : 1351359517 |
This book focuses on dopamine-mediated regulation of gene expression within the striatum and associated regions of the central nervous system. It is an excellent review of experimental data on interactions between neuronal systems at systemic, cellular, and molecular levels. Each of the chapters, written by the world's leading scientists, provides an understanding of anatomy, neurochemistry, and cellular and molecular effects. Such an understanding sheds light on the pathophysiology of central disorders involving the basal ganglia and leads to new approaches for the treatment of diseases such as Parkinson's disease and schizophrenia, and also addictions to psychostimulants such as cocaine and amphetamines.
Author | : Kalpana Merchant |
Publisher | : CRC Press Revivals |
Total Pages | : 224 |
Release | : 2019-01-25 |
Genre | : |
ISBN | : 9781138561120 |
This book focuses on dopamine-mediated regulation of gene expression within the striatum and associated regions of the central nervous system. It is an excellent review of experimental data on interactions between neuronal systems at systemic, cellular, and molecular levels. Each of the chapters, written by the world's leading scientists, provides an understanding of anatomy, neurochemistry, and cellular and molecular effects. Such an understanding sheds light on the pathophysiology of central disorders involving the basal ganglia and leads to new approaches for the treatment of diseases such as Parkinson's disease and schizophrenia, and also addictions to psychostimulants such as cocaine and amphetamines.
Author | : Heinz Steiner |
Publisher | : Academic Press |
Total Pages | : 729 |
Release | : 2010-03-17 |
Genre | : Medical |
ISBN | : 008091215X |
The Basal Ganglia comprise a group of forebrain nuclei that are interconnected with the cerebral cortex, thalamus and brainstem. Basal ganglia circuits are involved in various functions, including motor control and learning, sensorimotor integration, reward and cognition. The importance of these nuclei for normal brain function and behavior is emphasized by the numerous and diverse disorders associated with basal ganglia dysfunction, including Parkinson’s disease, Tourette’s syndrome, Huntington’s disease, obsessive-compulsive disorder, dystonia, and psychostimulant addiction. The Handbook of Basal Ganglia provides a comprehensive overview of the structural and functional organization of the basal ganglia, with special emphasis on the progress achieved over the last 10-15 years. Organized in six parts, the volume describes the general anatomical organization and provides a review of the evolution of the basal ganglia, followed by detailed accounts of recent advances in anatomy, cellular/molecular, and cellular/physiological mechanisms, and our understanding of the behavioral and clinical aspects of basal ganglia function and dysfunction. Synthesizes widely dispersed information on the behavioral neurobiology of the basal ganglia, including advances in the understanding of anatomy, cell-molecular and cell-physiological mechanisms, and behavioral/clinical aspects of function and dysfunction Features a truly international cast of the preeminent researchers in the field Fully explores the clinically relevant impact of the basal ganglia on various psychiatric and neurological diseases
Author | : |
Publisher | : |
Total Pages | : 1828 |
Release | : 2000 |
Genre | : Medicine |
ISBN | : |
Author | : M. Endo |
Publisher | : Springer Science & Business Media |
Total Pages | : 674 |
Release | : 2012-12-06 |
Genre | : Science |
ISBN | : 3642570836 |
Cells maintain uneven distribution of Na, K and Ca ions across the cell membrane and membranes of intracellular organellae. Cells exert their functions by allowing for some ion to cross the membrane through ion channels which either produces an electrical effect across the membrane or switches on a series of chemical or physicochemical reactions. This is a comprehensive book about these vitally important ion channels with detailed description of the molecular structure and function and especially of activators and inhibitors. All chapters are written by renowned specialists in their field.
Author | : Robert Miller |
Publisher | : CRC Press |
Total Pages | : 324 |
Release | : 2003-09-02 |
Genre | : Science |
ISBN | : 0203304918 |
Brain Dynamics and the Striatal Complex, the first volume in the Conceptual Advances in Brain Research book series, relates dynamic function to cellular structure and synaptic organization in the basal ganglia. The striatum is the largest nucleus within the basal ganglia and therefore plays an important role in understanding structure/function relationships. Areas covered include dopaminergic input to the striatum, organization of the striatum, and the interaction between the striatum and the cerebral cortex.
Author | : Katarzyna Stachowicz |
Publisher | : Frontiers Media SA |
Total Pages | : 197 |
Release | : 2023-01-02 |
Genre | : Science |
ISBN | : 2832510434 |
Author | : John Calvin M. Brust |
Publisher | : Butterworth-Heinemann |
Total Pages | : 504 |
Release | : 2004 |
Genre | : Anatomy |
ISBN | : 9780750673136 |
The 2nd Edition of this comprehensive text features practical guidance on how to diagnose and manage the neurological effects and complications of every major category of recreationally used drugs. Book jacket.
Author | : Charles J. Wilson |
Publisher | : Frontiers E-books |
Total Pages | : 456 |
Release | : |
Genre | : |
ISBN | : 2889190366 |
This volume contains articles describing research on the basic, pre-clinical and clinical neuroscience of the basal ganglia written by attendees of the 10th Triennial Meeting of the International Basal Ganglia Society (IBAGS) that was held June 20-24th, 2010 at the Ocean Place Resort in Long Branch, New Jersey, USA. For each of the preceding 9 IBAGS meetings, the meeting proceedings were published conventionally as a volume in the Advances in Behavioral Biology series. These volumes were expensive, were published only in very small quantities, had very limited availability to both basal ganglia researchers and the general neuroscience community, were not available on-line and the articles contained in each were not indexed in online searchable databases. Now, for the first time, IBAGS is taking full advantage of modern innovations in scientific publication and publishing IBAGS X as a Research Topics issue of Frontiers in Systems Neuroscience. The issue will be available on-line and is fully indexed by searchable databases including PubMed. Articles will include reports on the latest research on the anatomy and neurophysiology of single neurons and functional circuitry in the striatum, globus pallidus, subthalamic nucleus and substantia nigra as well as the latest data on animal models of basal ganglia dysfunction as well as behavioral and clinical studies in human patients.
Author | : Udo Rüb |
Publisher | : Springer |
Total Pages | : 154 |
Release | : 2015-09-29 |
Genre | : Medical |
ISBN | : 331919285X |
This monograph describes the progress in neuropathological HD research made during the last century, the neuropathological hallmarks of HD and their pathogenic relevance. Starting with the initial descriptions of the progressive degeneration of the striatum as one of the key events in HD, the worldwide practiced Vonsattel HD grading system of striatal neurodegeneration will be outlined. Correlating neuropathological data with results on the functional neuroanatomy of the human brain, subsequent chapters will highlight recent HD findings: the neuronal loss in the cerebral neo-and allocortex, the neurodegeneration of select thalamic nuclei, the affection of the cerebellar cortex and nuclei, the involvement of select brainstem nuclei, as well as the pathophysiological relevance of these pathologies for the clinical picture of HD. Finally, the potential pathophysiological role of neuronal huntingtin aggregations and the most important and enduring challenges of neuropathological HD research are discussed.