Pharmacogenetics Of Psychotropic Drugs
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| Author | : Bernard Lerer |
| Publisher | : Cambridge University Press |
| Total Pages | : 470 |
| Release | : 2011-04-28 |
| Genre | : Medical |
| ISBN | : 9781139433822 |
Pharmacogenetics and pharmacogenomics are areas of significant importance at the interface of molecular genetics and psychopharmacology, with implications for drug development and clinical practice. This 2002 book provides a conceptual framework for understanding and studying the pharmacogenetics of psychotropic drugs, reviews advances in the field, and describes the established findings. Coverage extends to antipsychotics, antidepressants, mood stabilising, cognitive-enhancing and anxiolytic drugs. Chapters also examine the interface of pharmacogenetics with substance dependence and brain imaging, and consider its impact on the biotechnology and pharmaceutical industries. This book defines the young field of pharmacogenetics as it applies to psychotropic drugs, and is therefore of interest to all clinicians and researchers working in this field.
| Author | : David Mrazek |
| Publisher | : Oxford University Press |
| Total Pages | : 276 |
| Release | : 2010-06-10 |
| Genre | : Medical |
| ISBN | : 0195367294 |
Psychiatric Pharmacogenomics is a book written to help clinicians to use pharmacogenomic testing to improve the pharmacotherapy that they provide for their patients. It is designed to teach clinicians how to order pharmacogenomic tests and interpret the results. Clinical examples are used to underscore the specific indications for pharmacogenomic testing and to clarify the clinical usefulness of identifying atypical genotypes that result in problematic responses to medication. The first section of the book begins with a basic review of molecular genetics. Additionally, the book also includes an extensive glossary of technical terms associated with molecular genetics and pharmacogenomics. The clinical utility of pharmacogenomic testing is demonstrated throughout the book by describing the implications of genetic variations for the care of individual patients. The second section of the book is organized into fourteen chapters that each focus on the clinical implications of testing for specific genes for which variants have been associated with either therapeutic response or side effects of psychotropic medications. Each of these chapters is structured in the same manner and involves a description of the gene and its significant variants. Each chapter also includes one or more clinical vignettes. The third section of the book discusses the clinical usefulness of pharmacogenomic testing, ethical issues associated with pharmacogenomic testing, and provides predictions for the future development of more sophisticated pharmacogenomic testing.
| Author | : Weimin Cai |
| Publisher | : Springer |
| Total Pages | : 289 |
| Release | : 2021-06-13 |
| Genre | : Medical |
| ISBN | : 9789811538971 |
This book provides an introduction to the principles of pharmacogenomics and precision medicine, followed by the pharmacogenomics aspects of major therapeutic areas such as cardiovascular disease, cancer, organ transplantation, psychiatry, infection, antithrombotic drugs. It also includes genotyping technology and therapeutic drug monitoring in Pharmacogenomics; ethical, Legal and Regulatory Issues; cost-effectiveness of pharmacogenetics-guided treatment; application of pharmacogenomics in drug discovery and development and clinical Implementation of Pharmacogenomics for Personalized Precision Medicine. The contributors of Pharmacogenomics in Precision Medicine come from a team of experts, including professors from academic institutions and practitioner from hospital. It will give an in-depth overview of the current state of pharmacogenomics in drug therapy for all health care professionals and graduate students in the era of precision medicine.
| Author | : Chris Aiken |
| Publisher | : |
| Total Pages | : 226 |
| Release | : 2021-10 |
| Genre | : Medical |
| ISBN | : 9781732952263 |
Prescribing Psychotropics bridges the gap between the complexities of drug pharmacokinetics and everyday clinical practice, providing clinicians more insight into how psychiatric drugs behave (or misbehave!) once their patients take them. The book also includes a series of unusually practical charts and tables that prescribers will find invaluable as they make medication decisions. What you'll find inside: The basics of drug metabolism What you really need to know about drug interactions Food and drink effects on medications Recreational drug interactions Gender and drug metabolism Drug metabolism and ethnicity More than 70 quick-reference tables, charts, and figures
| Author | : Kalyna Z. Bezchlibnyk-Butler |
| Publisher | : Hogrefe & Huber Publishing |
| Total Pages | : 76 |
| Release | : 1989 |
| Genre | : Medical |
| ISBN | : |
Includes bibliography, glossary, and an extensive index which cross-references generic and trade names. New editions are available on a subscription basis.
| Author | : Yui-Wing Francis Lam |
| Publisher | : Academic Press |
| Total Pages | : 515 |
| Release | : 2013-02-12 |
| Genre | : Science |
| ISBN | : 0123983037 |
Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation includes discussions and viewpoints from the academic, regulatory, pharmaceutical, clinical, socio-ethical and economic perspectives. Each chapter presents an overview of the potential or opportunity within the areas discussed and also outlines foreseeable challenges and limitations in moving pharmacogenomics into drug development and direct therapeutic applications. This edited book contains review questions for a more in-depth analysis of the implications of pharmacogenomics and discussion points to generate ideas on best to move the field forward. Clinical pearls and case studies are used to illustrate real-life experiences and both successful and unsuccessful applications. Tables, figures, and annotations are included throughout the book to facilitate understanding and further reference. - Multi-contributed book and chapters are written by contributors who are experts in their field - Provides perspectives from those involved in all aspects of pharmacogenomics—including academic, regulatory, economic, industry and medical—to illustrate how all of the pieces fit together and where the challenges may be - Includes case studies of both successful and unsuccessful applications so readers can consider the potential and challenges in moving the science into drug development and direct therapeutic applications - Chapters contain discussion questions and clinical pearls and enable readers to reflect on how to move pharmacogenomics forward and apply these observations and useful tips to their own work and research
| Author | : Russ B. Altman |
| Publisher | : Cambridge University Press |
| Total Pages | : 283 |
| Release | : 2012-01-23 |
| Genre | : Science |
| ISBN | : 1107377471 |
The study of pharmacogenetics and pharmacogenomics focuses on how our genes and complex gene systems influence our response to drugs. Recent progress in clinical therapeutics has led to the discovery of new biomarkers that make it technically easier to identify groups of patients which are more or less likely to respond to individual therapies. The aim is to improve personalised medicine - not simply to prescribe the right medicine, but to deliver the right drug at the right dose at the right time. This textbook brings together leading experts to discuss the latest information on how human genetics impacts drug response phenotypes. It presents not only the basic principles of pharmacogenetics, but also clinically valuable examples that cover a broad range of specialties and therapeutic areas. This textbook is an invaluable introduction to pharmacogenetics and pharmacogenomics for health care professionals, medical students, pharmacy students, graduate students and researchers in the biosciences.
| Author | : Joseph F. Goldberg |
| Publisher | : Cambridge University Press |
| Total Pages | : 611 |
| Release | : 2021-04-29 |
| Genre | : Medical |
| ISBN | : 1108450741 |
A practical guide translating clinical trials findings, across major psychiatric disorders, to devise tailored, evidence-based treatments.
| Author | : Francisco López-Muñoz |
| Publisher | : Springer |
| Total Pages | : 917 |
| Release | : 2016-11-16 |
| Genre | : Medical |
| ISBN | : 8132228030 |
This work is a guidebook for clinicians who are involved in treating depressive patients and also serves the research scientists who are working on the psychopharmacological mechanisms of antidepressant actions and psychopathological mechanisms underlying mood disorders. Mood disorders such as major depressive disorder (MDD), bipolar disorder (BPD) and seasonal affective disorder (SAD) are the most disabling disorders that are among the most expensive of all medical illnesses. The pathophysiology of mood disorders is very complex and involves many mechanisms like circadian rhythm disruption, sleep abnormalities, melatonin rhythm abnormalities and alterations in melatonin receptor mechanisms, abnormalities in monoaminergic neurotransmitter mechanisms, glutamatergic release mechanisms, hippocampal neurogenesis, and abnormal immune and cytokine release mechanisms. Many antidepressants that are in clinical use today including the recently introduced novel agents like agomelatine or other antidepressants cause clinical remission by resynchronizing disrupted circadian rhythms and melatonin receptor functions, enhancing monoaminergic neurotransmission, promoting hippocampal neurogenesis, and regulating immune mechanisms. This book explains various etiological factors that are involved in the pathogenesis of mood disorders and the mechanisms of therapeutic actions of antidepressants including the recently introduced agomelatine and other antidepressants that exhibit rapid onset of action with greater efficacy and fewer side effects. .
| Author | : Irving I. Gottesman |
| Publisher | : W. H. Freeman |
| Total Pages | : 296 |
| Release | : 1990-09-15 |
| Genre | : Science |
| ISBN | : 9780716721475 |
Sorting out fact from fiction, one of the world's leading experts presents an absorbing account of what is actually know about the complex subject of schizophrenia.
