Pharmaceutical Drug Analysis By Atomic Absorption Spectroscopy
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| Author | : Sunil Jawla |
| Publisher | : LAP Lambert Academic Publishing |
| Total Pages | : 80 |
| Release | : 2013 |
| Genre | : |
| ISBN | : 9783659409059 |
Naproxen and ibuprofen (aryl propionic acid derivatives) both are classified as non-steroidal anti-inflammatory agents. Except HPLC, no sensitive methods were reported for both the drugs. HPLC methods suffer from two drawbacks- first; requirement of costly chemicals and second; more time consuming. Because atomic absorption spectroscopy (AAS) methods are simple, sensitive, rapid, reproducible and uses low cost chemicals. The objective of present research work was to develop highly sensitive and economical analytical methods for the quantitative estimation of naproxen and ibuprofen in pharmaceutical formulations by AAS. The methods were based on the reaction of naproxen and ibuprofen with copper and cobalt chloride to form coloured metal complexes. These complexes were extracted with organic solvents and digested with acids. Naproxen and ibuprofen were indirectly estimated by AAS via the determination of the copper and cobalt content in the formed complexes. The proposed methods may be used for routine analysis of pharmaceutical formulations containing aryl propionic acid derivatives and similar pharmaceutical drugs by the analytical chemist.
| Author | : Muhammad Sajid Hamid Akash |
| Publisher | : Springer Nature |
| Total Pages | : 235 |
| Release | : 2019-12-17 |
| Genre | : Medical |
| ISBN | : 9811515476 |
Recent advances in the pharmaceutical sciences and biotechnology have facilitated the production, design, formulation and use of various types of pharmaceuticals and biopharmaceuticals. This book provides detailed information on the background, basic principles, and components of techniques used for the analysis of pharmaceuticals and biopharmaceuticals. Focusing on those analytical techniques that are most frequently used for pharmaceuticals, it classifies them into three major sections and 19 chapters, each of which discusses a respective technique in detail. Chiefly intended for graduate students in the pharmaceutical sciences, the book will familiarize them with the components, working principles and practical applications of these indispensable analytical techniques.
| Author | : Ashutosh Kar |
| Publisher | : New Age International |
| Total Pages | : 558 |
| Release | : 2005-12 |
| Genre | : Medical |
| ISBN | : 9788122415827 |
About the Book: During the past two decades, there have been magnificent and significant advances in both analytical instrumentation and computerized data handling devices across the globe. In this specific context the remarkable proliferation of windows
| Author | : Lena Ohannesian |
| Publisher | : CRC Press |
| Total Pages | : 605 |
| Release | : 2001-11-09 |
| Genre | : Medical |
| ISBN | : 0824741943 |
Exploring the analysis of pharmaceuticals, including polymorphic forms, this book discusses regulatory requirements in pharmaceutical product development and pharmaceutical testing. It covers methods of drug separation and procedures such as capillary electrophoresis for chromatographic separation of molecules. Additional topics include drug formulation analysis using vibrational and magnetic resonance spectroscopy and identification of drug metabolites and decomposition products using such techniques as mass spectrometry. The book provides more than 300 tables, equations, drawings, and photographs, and convenient, easy-to-use indices, facilitating quick access to each topic.
| Author | : Anette Müllertz |
| Publisher | : Springer |
| Total Pages | : 829 |
| Release | : 2016-08-30 |
| Genre | : Medical |
| ISBN | : 1493940295 |
The aim of this book is to present a range of analytical methods that can be used in formulation design and development and focus on how these systems can be applied to understand formulation components and the dosage form these build. To effectively design and exploit drug delivery systems, the underlying characteristic of a dosage form must be understood--from the characteristics of the individual formulation components, to how they act and interact within the formulation, and finally, to how this formulation responds in different biological environments. To achieve this, there is a wide range of analytical techniques that can be adopted to understand and elucidate the mechanics of drug delivery and drug formulation. Such methods include e.g. spectroscopic analysis, diffractometric analysis, thermal investigations, surface analytical techniques, particle size analysis, rheological techniques, methods to characterize drug stability and release, and biological analysis in appropriate cell and animal models. Whilst each of these methods can encompass a full research area in their own right, formulation scientists must be able to effectively apply these methods to the delivery system they are considering. The information in this book is designed to support researchers in their ability to fully characterize and analyze a range of delivery systems, using an appropriate selection of analytical techniques. Due to its consideration of regulatory approval, this book will also be suitable for industrial researchers both at early stage up to pre-clinical research.
| Author | : Irving Sunshine |
| Publisher | : Springer |
| Total Pages | : 504 |
| Release | : 1981-10-06 |
| Genre | : Medical |
| ISBN | : |
| Author | : David C Lee |
| Publisher | : John Wiley & Sons |
| Total Pages | : 384 |
| Release | : 2009-02-12 |
| Genre | : Science |
| ISBN | : 1405172991 |
The use of analytical sciences in the discovery, development andmanufacture of pharmaceuticals is wide-ranging. From the analysisof minute amounts of complex biological materials to the qualitycontrol of the final dosage form, the use of analytical technologycovers an immense range of techniques and disciplines. This book concentrates on the analytical aspects of drugdevelopment and manufacture, focusing on the analysis of the activeingredient or drug substance. It provides those joining theindustry or other areas of pharmaceutical research with a source ofreference to a broad range of techniques and their applications,allowing them to choose the most appropriate analytical techniquefor a particular purpose. The volume is directed at analytical chemists, industrialpharmacists, organic chemists, pharmaceutical chemists andbiochemists.
| Author | : G. Vidya Sagar |
| Publisher | : Pharmamed Press |
| Total Pages | : 551 |
| Release | : 2009 |
| Genre | : Drugs |
| ISBN | : 9781441668608 |
1 . Chromatography 2. Column Chromatography 3. Thin Layer Chromatography 4. Paper Chromatography 5. Ion Exchange Chromatography 6. Gas Chromatography 7. High Performance Liquid Chromatography 8. High Performance Thin Layer Chromatography 9. Introduction to Spectroscopy 10. UV & Visible Spectroscopy 11. Flourimetry 12. Nephelometry and Turbidimetry 13. Atomic Absorption Spectroscopy 14. Flame Photometry 15. Mass Spectroscopy 16. Infrared Spectroscopy 17 . Nuclear Magnetic Resonance Spectroscopy 18. Water Analysis 19. Validation 20. X-ray Spectroscopy Question Bank
| Author | : Bernhard Welz |
| Publisher | : John Wiley & Sons |
| Total Pages | : 965 |
| Release | : 2008-11-21 |
| Genre | : Science |
| ISBN | : 3527611681 |
The thoroughly revised new edition of this best-seller, presents the wide use of AAS in numerous fields of application. The comparison between the different AAS techniques enables the reader to find the best solution for his analytical problem. Authors Bernhard Welz and Michael Sperling have succeeded in finding a balance between theoretical fundamentals and practical applications. The new chapter 'physical fundamentals' describes the basic principles of AAS. The development of AAS is now described in a separate chapter. Further new chapters are devoted to the latest developments in the field of flow injection and the use of computers for laboratory automation. Methodological progress e. g. speciation analysis is also covered in this new edition. The index and the extensive bibliography make this book a unique source of information. It will prove useful not only for analytical chemists, out also spectroscopists in industry, institutes, and universities. Atomic Absorption Spectrometry will also be invaluable for clinics and research institutes in the fields of biochemistry, medicine, food technology, geology, metallurgy, petrochemistry, and mineralogy.
| Author | : Steen Honoré Hansen |
| Publisher | : John Wiley & Sons |
| Total Pages | : 332 |
| Release | : 2015-07-20 |
| Genre | : Science |
| ISBN | : 1118716825 |
Bioanalysis of Pharmaceuticals: Sample Preparation, Separation Techniques and Mass Spectrometry is the first student textbook on the separation science and mass spectrometry of pharmaceuticals present in biological fluids with an educational presentation of the principles, concepts and applications. It discusses the chemical structures and properties of low- and high-molecular drug substances; the different types of biological samples and fluids that are used; how to prepare the samples by extraction, and how to perform the appropriate analytical measurements by chromatographic and mass spectrometric methods. Bioanalysis of Pharmaceuticals: Sample Preparation, Separation Techniques and Mass Spectrometry: Is an introductory student textbook discussing the different principles and concepts clearly and comprehensively, with many relevant and educational examples Focuses on substances that are administered as human drugs, including low-molecular drug substances, peptides, and proteins Presents both the basic principles that are regularly taught in universities, along with the practical use of bioanalysis as carried out by researchers in the pharmaceutical industry and in hospital laboratories Is aimed at undergraduate students, scientists, technicians and researchers in industry working in the areas of pharmaceutical analyses, biopharmaceutical analyses, biological and life sciences The book includes multiple examples to illustrate the theory and application, with many practical aspects including calculations, thus helping the student to learn how to convert the data recorded by instruments into the real concentration of the drug substances within the biological sample.
