PET and SPECT of Neurobiological Systems

PET and SPECT of Neurobiological Systems
Author: Rudi A.J.O. Dierckx
Publisher: Springer Nature
Total Pages: 1127
Release: 2020-09-29
Genre: Medical
ISBN: 3030531767

This book, now in a fully updated second edition, is a comprehensive and up-to-date guide to the use of PET and SPECT for the imaging of neurobiological systems. Diverse aspects of neurotransmission in the brain are discussed, such as visualization and quantification of neuroreceptors, neuroinflammatory markers, transporters, and enzymes as well as neurotransmitter synthesis, β-amyloid deposition, cerebral blood flow, and the metabolic rate of glucose. The latest results in probe development are also detailed. A wide range of systems not addressed in the first edition are covered, reflecting the advances made in recent years. The book combines the expertise of authors internationally renowned for their dedication to the development of novel probes and techniques for the investigation of neurobiological systems. Most chapters are written jointly by radiochemists and nuclear medicine specialists to ensure a multidisciplinary approach. This state of the art compendium will be valuable to all with an interest in clinical and preclinical neuroscience. Companion volumes on the use of PET and SPECT in neurology and psychiatry complete a trilogy.

PET and SPECT in Neurology

PET and SPECT in Neurology
Author: Rudi A.J.O. Dierckx
Publisher: Springer
Total Pages: 1103
Release: 2014-06-02
Genre: Medical
ISBN: 3642543073

PET and SPECT in Neurology highlight the combined expertise of renowned authors whose dedication to the investigation of neurological disorders through nuclear medicine technology has achieved international recognition. Classical neurodegenerative disorders are discussed as well as cerebrovascular disorders, brain tumors, epilepsy, head trauma, coma, sleeping disorders and inflammatory and infectious diseases of the CNS. The latest results in nuclear brain imaging are detailed. Most chapters are written jointly by a clinical neurologist and a nuclear medicine specialist to ensure a multidisciplinary approach. This state-of-the-art compendium will be valuable not only to neurologists and radiologists/nuclear medicine specialists but also to interested general practitioners and geriatricians. It is the second volume of a trilogy on PET and SPECT imaging in the neurosciences, the other volumes covering PET and SPECT in psychiatry and in neurobiological systems.

PET and SPECT in Psychiatry

PET and SPECT in Psychiatry
Author: Rudi A.J.O. Dierckx
Publisher: Springer Science & Business Media
Total Pages: 851
Release: 2014-03-28
Genre: Medical
ISBN: 3642403840

PET and SPECT in Psychiatry showcases the combined expertise of renowned authors whose dedication to the investigation of psychiatric disease through nuclear medicine technology has achieved international recognition. The classical psychiatric disorders as well as other subjects – such as suicide, sleep, eating disorders, and autism – are discussed and the latest results in functional neuroimaging are detailed. Most chapters are written jointly by a clinical psychiatrist and a nuclear medicine expert to ensure a multidisciplinary approach. This state of the art compendium will be valuable to all who have an interest in the field of neuroscience, from the psychiatrist and the radiologist/nuclear medicine specialist to the interested general practitioner and cognitive psychologist. It is the first volume of a trilogy on PET and SPECT imaging in the neurosciences; other volumes will focus on PET and SPECT in neurology and PET and SPECT of neurobiological systems.

Imaging of the Human Brain in Health and Disease

Imaging of the Human Brain in Health and Disease
Author: Philip Seeman
Publisher: Elsevier
Total Pages: 534
Release: 2013-11-15
Genre: Science
ISBN: 012418684X

Brain imaging technology remains at the forefront of advances in both our understanding of the brain and our ability to diagnose and treat brain disease and disorders. Imaging of the Human Brain in Health and Disease examines the localization of neurotransmitter receptors in the nervous system of normal, healthy humans and compares that with humans who are suffering from various neurologic diseases. Opening chapters introduce the basic science of imaging neurotransmitters, including sigma, acetylcholine, opioid, and dopamine receptors. Imaging the healthy and diseased brain includes brain imaging of anger, pain, autism, the release of dopamine, the impact of cannabinoids, and Alzheimer's disease. This book is a valuable companion to a wide range of scholars, students, and researchers in neuroscience, clinical neurology, and psychiatry, and provides a detailed introduction to the application of advanced imaging to the treatment of brain disorders and disease. - A focused introduction to imaging healthy and diseased brains - Focuses on the primary neurotransmitter release - Includes sigma, acetylcholine, opioid, and dopamine receptors - Presents the imaging of healthy and diseased brains via anger, pain, autism, and Alzheimer's disease

Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research

Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research
Author: National Research Council
Publisher: National Academies Press
Total Pages: 223
Release: 2003-08-22
Genre: Science
ISBN: 030916785X

Expanding on the National Research Council's Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Methods for assessing and ensuring an animal's well-being. General animal-care elements as they apply to neuroscience and behavioral research, and common animal welfare challenges this research can pose. The use of professional judgment and careful interpretation of regulations and guidelines to develop performance standards ensuring animal well-being and high-quality research. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research treats the development and evaluation of animal-use protocols as a decision-making process, not just a decision. To this end, it presents the most current, in-depth information about the best practices for animal care and use, as they pertain to the intricacies of neuroscience and behavioral research.

Dopaminergic System Function and Dysfunction: Experimental Approaches

Dopaminergic System Function and Dysfunction: Experimental Approaches
Author: José Antonio Fuentealba-Evans
Publisher: Springer Nature
Total Pages: 345
Release: 2022-12-07
Genre: Medical
ISBN: 1071627996

This volume provides a variety of technical approaches to study dopamine system function and dysfunction. Chapters guide readers through dopamine release in ex vivo and freely moving animals, multi-recording devices for in vivo simultaneous single cell and population activity, in silico modeling of dopamine neurons activity, neuroanatomical approaches, unbiased stereology, ultrastructural analyses of dopaminergic neurons, and axonal innervation. Additionally, chapters also incorporate pharmacological tools to model neuropsychiatric diseases, novel behavioral paradigms to dissect dopamine's role in behavior, and functional imaging to follow human dopamine system development. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Comprehensive and cutting-edge, Dopamine Neurotransmission aims to be a valuable resource for researchers in various disciplines.

Neurobiology of Bipolar Disorder

Neurobiology of Bipolar Disorder
Author: Joao L. de Quevedo
Publisher: Academic Press
Total Pages: 472
Release: 2020-11-25
Genre: Medical
ISBN: 012819183X

The Neurobiology of Bipolar Disorder: Road to Novel Therapeutics combines the basic neurobiology of bipolar disorder with discussions of the most recent advances in research, including the interacting pathways implicated in the pathophysiology of bipolar disorder, genetic approaches and the pharmacogenomics of bipolar disorder. The basic foundational understanding of the neurobiology underlying the disorder, along with a comprehensive summary of the most recent advances in research combine to aid advanced students and researchers in their understanding of bipolar disorder management using novel and fast-acting pharmaceutical and neuromodulatory approaches. - Aids readers in understanding bipolar disorder in the context of NIMH Research Domain Criteria (RDoC) recommendations - Covers a range of existing and potential pharmacologic and non-pharmacologic treatment options, from lifestyle adjustments to novel therapeutics - Synthesizes a discussion of the cellular and molecular mechanisms underlying symptoms with clinical aspects of bipolar disorder

Understanding Asperger Syndrome: A Comprehensive Treatise on Medical, Neurobiological, and Holistic Perspectives

Understanding Asperger Syndrome: A Comprehensive Treatise on Medical, Neurobiological, and Holistic Perspectives
Author: Dr. Spineanu Eugenia
Publisher: Dr. Spineanu Eugenia
Total Pages: 119
Release: 2024-10-28
Genre: Medical
ISBN:

Curious about the complexities of Asperger Syndrome and how it shapes unique experiences in social interaction, communication, and cognition? This insightful guide to Asperger Syndrome offers readers a thorough understanding, from diagnostic history to the latest in neurobiological research. Key Features: DETAILED HISTORICAL CONTEXT: Uncover Asperger Syndrome's evolution from initial discovery to modern-day perspectives. COMPREHENSIVE DIAGNOSTIC CRITERIA: Break down the intricacies of criteria used for identifying Asperger Syndrome. EPIDEMIOLOGY AND DEMOGRAPHICS: Explore global prevalence and the gender, age, and cultural factors that influence it. IN-DEPTH CLINICAL CHARACTERISTICS: Navigate the behavioral, sensory, and cognitive patterns that define Asperger Syndrome. INSIGHTFUL INTERVENTION STRATEGIES: Discover targeted support options and interventions that foster understanding and inclusivity. This book serves as a valuable resource for parents, educators, and healthcare professionals, combining clinical insights with practical strategies to support individuals with Asperger Syndrome effectively.

5-HT2A Receptors in the Central Nervous System

5-HT2A Receptors in the Central Nervous System
Author: Bruno P. Guiard
Publisher: Springer
Total Pages: 450
Release: 2018-02-14
Genre: Medical
ISBN: 3319704745

5-HT2A receptors are G-protein coupled receptors that are widely distributed throughout the brain, most notably on neuronal and glial cells. 5-HT2A receptors have been implicated in various central physiological functions including mood regulation, memory, sleep, nociception, eating, and reward behaviors, and they are also believed to control the cardiovascular system. This book provides a comprehensive overview of these receptors including sections on their properties and distribution, approaches for their study, their role in a number of brain functions and diseases, and their role as therapeutic targets. ​