This thesis is highly interdisciplinary; literature, art, and history accounts were all used to determine plague saint status and grouping, but art was my foundation. I examined important works of art directly associated with the plague and noted which saints appeared multiple times. The results from that assessment spurred further hagiographic and literary study. It was clear that these saints had multivarient connections to the plague. This study into the lives of the saints reaffirms their placement in the artistic and religious history of the pestilential epidemic of the Medieval and early Renaissance periods.