Personalized Pathway-Activated Systems Imaging in Oncology

Personalized Pathway-Activated Systems Imaging in Oncology
Author: Tomio Inoue
Publisher: Springer
Total Pages: 245
Release: 2017-03-01
Genre: Medical
ISBN: 9811033498

This comprehensive volume covers radiopharmaceuticals developed for pathway-directed systems in imaging and theranostic applications. We now are at the cutting edge of providing personalized treatment with increased use in oncology of these new radiopharmaceuticals. Trends in high-resolution instrumentation development, quality assurance systems and regulatory compliance for radiopharmaceuticals, clinical evaluation of radiopharmaceuticals, and benefits and pitfalls of the current clinical FDG PET are discussed. Radiopharmaceuticals are used for diagnosis of diseases of the central nervous and cardiovascular systems and for staging, restaging, and treatment planning for cancers. Nuclear biomarkers allow precise measurement of molecular pathways on a whole-body image upon administration of functional radiolabeled agents, and nuclear imaging agents have potential use in patient selection, pharmacokinetic, dosage-finding, and proof-of-concept studies. Nuclear imaging agents and hybrid instrumentation also provide sensitive and specific answers for differential responsiveness in therapeutic outcome. This book serves as a reference for moving the discovery and development of radiopharmaceuticals from the workbench to clinical applications. It thus benefits not only clinicians but also translational research scientists—molecular biologists, chemists, imaging scientists, pharmaceutical developers, physicists, and support staff.

Husband & Reznek's Imaging in Oncology

Husband & Reznek's Imaging in Oncology
Author: Anju Sahdev
Publisher: CRC Press
Total Pages: 2210
Release: 2020-10-18
Genre: Medical
ISBN: 1351402048

This comprehensive reference provides an overview of the general principles of cancer staging, as well as specific discussions of each tumour type across the body, including lymphoma and haematological malignancies. For each tumour, the pattern of disease involvement and disease spread are emphasized, the state-of-the-art imaging features surveyed, and the latest tumour staging and methods to assess treatment response are addressed. Separate sections discuss metastatic disease and the effects of treatment on normal and diseased tissues. The final section of the book highlights emerging functional and molecular imaging techniques to evaluate the different biological hallmarks of cancer.

Research Ethics for Environmental Health

Research Ethics for Environmental Health
Author: Friedo Zölzer
Publisher: Routledge
Total Pages: 244
Release: 2021-12-19
Genre: Nature
ISBN: 1000516385

Research Ethics for Environmental Health explores the ethical basis of environmental health research and related aspects of risk assessment and control. Environmental health encompasses the assessment and control of those environmental factors that can potentially affect human health, such as radiation, toxic chemicals and other hazardous agents. It is often assumed that the assessment part is just a matter of scientific research, and that control is a matter of implementing standards that unambiguously follow from that research. But it is less commonly understood that environmental health also requires addressing questions of an ethical nature. Coming from multiple disciplines and nine different countries, the contributors to this book critically examine a diverse range of ethical concerns in modern environmental health research. This book will be of great interest to scholars and practitioners of environmental health, as well as researchers in applied ethics, environmental ethics, medical ethics, bioethics and those concerned with chemical and radiation protection.

AACR 2016: Abstracts 2697-5293

AACR 2016: Abstracts 2697-5293
Author: American Association for Cancer Research (AACR)
Publisher: CTI Meeting Technology
Total Pages: 1518
Release: 2016-03-28
Genre: Medical
ISBN:

The AACR Annual Meeting is a must-attend event for cancer researchers and the broader cancer community. This year's theme, "Delivering Cures Through Cancer Science," reinforces the inextricable link between research and advances in patient care. The theme will be evident throughout the meeting as the latest, most exciting discoveries are presented in every area of cancer research. There will be a number of presentations that include exciting new data from cutting-edge clinical trials as well as companion presentations that spotlight the science behind the trials and implications for delivering improved care to patients. This book contains abstracts 2697-5293 presented on April 19-20, 2016, at the AACR Annual Meeting.

Systems Biology in Cancer Research and Drug Discovery

Systems Biology in Cancer Research and Drug Discovery
Author: Asfar S Azmi
Publisher: Springer Science & Business Media
Total Pages: 425
Release: 2012-09-29
Genre: Medical
ISBN: 9400748191

Systems Biology in Cancer Research and Drug Discovery provides a unique collection of chapters, by world-class researchers, describing the use of integrated systems biology and network modeling in the cancer field where traditional tools have failed to deliver expected promise. This book touches four applications/aspects of systems biology (i) in understanding aberrant signaling in cancer (ii) in identifying biomarkers and prognostic markers especially focused on angiogenesis pathways (iii) in unwinding microRNAs complexity and (iv) in anticancer drug discovery and in clinical trial design. This book reviews the state-of-the-art knowledge and touches upon cutting edge newer and improved applications especially in the area of network modeling. It is aimed at an audience ranging from students, academics, basic researcher and clinicians in cancer research. This book is expected to benefit the field of translational cancer medicine by bridging the gap between basic researchers, computational biologists and clinicians who have one ultimate goal and that is to defeat cancer.

Textbook of Personalized Medicine

Textbook of Personalized Medicine
Author: Kewal K. Jain
Publisher: Springer Nature
Total Pages: 744
Release: 2020-12-05
Genre: Medical
ISBN: 3030620808

This book is for personalized medicine as a prescription of specific treatments and therapeutics best suited for an individual and considers genetic as well as environmental factors that influence responses to therapy. Best approaches are described for integration of all available technologies for optimizing the therapy of individual patients. This comprehensive third edition covers the latest advances in personalized medicine and several chapters are devoted to various specialties, particulary cancer which is the largest area of application. The book discusses the development of personalized medicine and various players in it such as companies, academic institutions, the government, and the public as the consumer of healthcare. Additionally, the roles of bioinformatics, electronic health records, and digital technologies for personalized medicine are discussed. Textbook of Personalized Medicine, 3rd Edition serves as a convenient source of information for students at many levels and in a wide range of fields, including physicians, scientists, and decision makers in the biopharmaceutical and healthcare industries.

Cancer Proteomics

Cancer Proteomics
Author: Sayed S. Daoud
Publisher: Springer Science & Business Media
Total Pages: 263
Release: 2008
Genre: Medical
ISBN: 1588298582

This book covers current topics related to the use of proteomic strategies in cancer therapy as well as anticipated challenges that may arise from its application in daily practice. It details current technologies used in proteomics, examines the use proteomics in cell signaling, presents clinical applications of proteomics in cancer therapy, and looks at the role of the FDA in regulating the use of proteomics.

Principles of Molecular Diagnostics and Personalized Cancer Medicine

Principles of Molecular Diagnostics and Personalized Cancer Medicine
Author: Dongfeng Tan
Publisher: Lippincott Williams & Wilkins
Total Pages: 2177
Release: 2012-12-07
Genre: Medical
ISBN: 1469820641

The role of molecular genetics in the treatment of malignancy continues to grow at an astonishing rate. Today’s subspecialized multidisciplinary approach to oncology has incorporated advances in targeted molecular therapy, prognosis, risk assessment, and prevention—all based at least in part on molecular diagnostics and imaging. Inside this cutting-edge resource, readers will explore broad, comprehensive perspectives on the current trends in molecular diagnosis of cancer and personalized cancer medicine. Authoritative discussions share insights from noted experts in cancer research, clinical trials, molecular diagnostics, personalized therapy, bioinformatics, and federal regulations. From the basic mechanisms of carcinogenesis to the most advanced molecular screening, staging, and treatment technologies, readers will discover clear and straightforward discussions directly relevant to patient diagnosis and care.

Comprehensive Textbook of Clinical Radiology Volume I: Principles of Clinical Radiology, Multisystem Diseases & Head and Neck-E-book

Comprehensive Textbook of Clinical Radiology Volume I: Principles of Clinical Radiology, Multisystem Diseases & Head and Neck-E-book
Author: Praveen Gulati
Publisher: Elsevier Health Sciences
Total Pages: 2319
Release: 2023-05-15
Genre: Medical
ISBN: 8131263584

Comprehensive Textbook of Clinical Radiology is a fully integrated illustrated textbook of radiology to cater for residents and practising radiologists. It is a one-stop solution for all academic needs in radiology. It helps radiologists as a single reference book to gain complete knowledge instead of referring to multiple resources. More than 500 authors, recognized experts in their subspeciality, have contributed to this book. To meet the expectations of clinical radiologists, thorough clinical expertise and familiarity with all the imaging modalities appropriate to address their clinical questions are necessary, regardless of one's favoured subspeciality. To keep the content relevant to them, we have tried to stay upgraded to their level. This book comprises six volumes, which gives information on Radiological Anatomy, Embryology, Nomogram, Normal Variants, Physics, Imaging Techniques, and all the aspects of Diagnostic Radiology including Neuroradiology, Head and Neck, Chest and CVS, Abdomen, Obstetrics and Gynaecology, Breast, Musculoskeletal and Multisystem Disorders & related Interventional techniques. It will serve as a primary reference for residents and subspeciality trainees and fellows to facilitate their learning in preparation for their examination, and also the consultant radiologists in their daily clinical practice.This volume is subdivided into three sections. Section 1 covers the principles of clinical radiology and deals with basic to advanced aspects of general radiology. The physics of each imaging modality is described in detail for radiology residents. Principles of pathology, genetics and statistics important for radiologists from research point of view are enumerated. Basic principles of medicine including management of contrast reactions, basic and advanced life support which are important for radiologists in day to day practice are dealt in dedicated chapter. Section 2 covers the multisystem disorders that affect multiple body systems either at the same time or over a period of time. Imaging plays a vital role in identifying the extent of systems involved and also in diagnosis by recognising the pattern of systems involved. The last part of the section deals with the general principles of oncoimaging dealing with multisystem involvement and facilitates easier understanding of this complex subject. The format is ideal for both in-depth knowledge and daily reference. Section 3 covers head and neck imaging, anatomy of neck, techniques of imaging and paediatric neck. In addition, all neck spaces and lymph nodes are discussed with anatomy and pathology with high-quality images and line diagrams. Orbits, temporal bone, sinuses and skull base are included with discussion on imaging anatomy, variants and pathologies. Cancer imaging, PETCT and post-operative imaging are fully discussed along with TNM imaging. Unique chapters on Sleep apnea, Emergency Radiology, Dental imaging, Superficial and trans-spatial lesions and Imaging of all cranial nerves are included.

Nanotechnology-Based Targeted Drug Delivery Systems for Lung Cancer

Nanotechnology-Based Targeted Drug Delivery Systems for Lung Cancer
Author: Prashant Kesharwani
Publisher: Academic Press
Total Pages: 352
Release: 2019-01-26
Genre: Medical
ISBN: 0128163674

Nanotechnology-based Targeted Drug Delivery Systems for Lung Cancer is an indispensable resource that will help pharmaceutical scientists and clinical researchers design and develop novel drug delivery systems and devices for the treatment of lung cancer. As recent breakthroughs in nanomedicine are now making it possible to deliver drugs, genes and therapeutic agents to localized areas of disease to maximize clinical benefit, while also limiting unwanted side effects, this book explores promising approaches for the diagnosis and treatment of lung cancer using cutting-edge nanomedical technologies. Topics discussed include polymeric nanoparticles, solid lipid nanoparticles, liposomes, dendrimers, micelles and nanoemulsions. - Provides an overview of an array of nanotechnology-based drug delivery systems - Examines the design, synthesis and application of different nanocarriers in drug and gene delivery - Provides an in-depth understanding of the design of targeted nanotherapeutics and technologies and its implication in various site-specific cancers