Personalized Medicine In Neuroscience Molecular To System Approach
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| Author | : Ali Yadollahpour |
| Publisher | : Frontiers Media SA |
| Total Pages | : 169 |
| Release | : 2024-04-17 |
| Genre | : Science |
| ISBN | : 2832541275 |
Personalized or precision medicine (PM) is developing and adopting of the safest and most cost-effective therapeutic approach for each patient. PM approach aims to identify phenotypic and genotypic individual characteristics, observe how these parameters are correlated with the disease status, severity, and intervention responsiveness to predict the best personalized clinical protocol. On the other hand, the risk of severe toxicity and adverse effects might be related to the patient-specific characteristics.
| Author | : Evian Gordon |
| Publisher | : Oxford University Press |
| Total Pages | : 346 |
| Release | : 2011 |
| Genre | : Language Arts & Disciplines |
| ISBN | : 0195393805 |
This book takes an in depth and hard look at the current status and future direction of treatment predictive markers in Personalized Medicine for the brain from the perspectives of the researchers on the cutting edge and those involved in healthcare implementation. The contents provide a comprehensive text suitable as both a pithy introduction to and a clear summary of the "science to solutions" continuum in this developing field of Personalized Medicine and Integrative Neuroscience. The science includes both measures of genes using whole genome approaches and SNIPS as well as BRAINmarkers of direct brain function such as brain imaging, biophysical changes and objective cognitive and behavioral measurements. Personalized Medicine for Brain Disorders will soon be a reality using the comprehensive quantitative and standardized approaches to genomics, BRAINmarkers and cognitive function. Each chapter provides a review of recent relevant literature; show the solutions achieved through integrative neuroscience and applications in patient care thus providing a practical guide to the reader. The timeliness of this book's content is propitious providing bottom line information to educate practicing clinicians, health care workers and researchers, and also a pathway for undergraduate and graduates interested in further their understanding of and involvement in tailored personal solutions.
| Author | : Bernhard Baune |
| Publisher | : Academic Press |
| Total Pages | : 594 |
| Release | : 2019-10-16 |
| Genre | : Medical |
| ISBN | : 0128131772 |
Personalized Psychiatry presents the first book to explore this novel field of biological psychiatry that covers both basic science research and its translational applications. The book conceptualizes personalized psychiatry and provides state-of-the-art knowledge on biological and neuroscience methodologies, all while integrating clinical phenomenology relevant to personalized psychiatry and discussing important principles and potential models. It is essential reading for advanced students and neuroscience and psychiatry researchers who are investigating the prevention and treatment of mental disorders. - Combines neurobiology with basic science methodologies in genomics, epigenomics and transcriptomics - Demonstrates how the statistical modeling of interacting biological and clinical information could transform the future of psychiatry - Addresses fundamental questions and requirements for personalized psychiatry from a basic research and translational perspective
| Author | : Drozdstoy Stoyanov |
| Publisher | : Springer Nature |
| Total Pages | : 275 |
| Release | : 2023-05-10 |
| Genre | : Medical |
| ISBN | : 1071632302 |
This volume looks at the latest advancements in imaging neuroscience methods using magnetic resonance imaging (MRI) and electroencephalography (EEG) to study the healthy and diseased brain. The chapters in this book are organized into five parts. Parts One and Two cover an introduction to this field and the latest use of molecular models. Part Three explores neurophysiological methods for assessment, such as quantitative EEG and event-related potentials. Part Four discusses the advances and innovations made in computational anatomy, and Part Five addresses the challenges faced by researchers prior to the computational neuroscience to find wider translational applications in the field of psychiatry and mental health. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and comprehensive, Computational Neuroscience is a valuable tool for researchers in the psychiatry and mental health fields who want to learn more about ways to incorporate computational approaches into utility and validity of clinical methods.
| Author | : Peter J. Whitehouse, M.D. |
| Publisher | : Macmillan |
| Total Pages | : 336 |
| Release | : 2008-12-09 |
| Genre | : Health & Fitness |
| ISBN | : 0312368178 |
Challenges conventional perceptions about Alzheimer's disease to offer readers alternative approaches to memory loss and aging that can be aided through simple nutritional and exercise strategies.
| Author | : Qing Yan |
| Publisher | : Academic Press |
| Total Pages | : 184 |
| Release | : 2017-04-18 |
| Genre | : Computers |
| ISBN | : 0128043881 |
Translational Bioinformatics and Systems Biology Methods for Personalized Medicine introduces integrative approaches in translational bioinformatics and systems biology to support the practice of personalized, precision, predictive, preventive, and participatory medicine. Through the description of important cutting-edge technologies in bioinformatics and systems biology, readers may gain an essential understanding of state-of-the-art methodologies. The book discusses topics such as the challenges and tasks in translational bioinformatics; pharmacogenomics, systems biology, and personalized medicine; and the applicability of translational bioinformatics for biomarker discovery, epigenomics, and molecular dynamics. It also discusses data integration and mining, immunoinformatics, and neuroinformatics. With broad coverage of both basic scientific and clinical applications, this book is suitable for a wide range of readers who may not be scientists but who are also interested in the practice of personalized medicine. Introduces integrative approaches in translational bioinformatics and systems biology to support the practice of personalized, precision, predictive, preventive, and participatory medicine Presents a problem-solving oriented methodology to deal with practical problems in various applications Covers both basic scientific and clinical applications in order to enhance the collaboration between researchers and clinicians Brings integrative and multidisciplinary approaches to bridge the gaps among various knowledge domains in the field
| Author | : Babak Sokouti |
| Publisher | : Elsevier |
| Total Pages | : 356 |
| Release | : 2024-11-05 |
| Genre | : Science |
| ISBN | : 0443223270 |
Systems Biology and In-Depth Applications for Unlocking Diseases: Principles, tools and Application to Disease provides the essence of systems biology approaches in a practical manner, illustrating the basic principles essential to develop and model in real life science applications. Methodologies covered show how to interrogate biological data, with the purpose of obtaining insight about disease diagnosis, prognosis, and treatment. Sections provide an introduction and history of systems biology, discuss the tools and resources needed for structure and function of biological systems, and present evidence of systems biology in action. Examples include big data techniques, scale networks, mathematical model development, and much more. This is the perfect reference to provide the fundamental base of knowledge needed for systems biologists, professionals in systems medicine, computational biologists, and bioinformaticians. - Provides detailed and comprehensive coverage of the field of systems biology - Delivers instruction on how to interrogate biological data, with the purpose of obtaining insight about disease diagnosis, prognosis, and treatment - Makes effective steps towards personalized medicine in the treatment of disease - Explains effective disease treatment strategies at early diagnosis stages
| Author | : Sanket Joshi |
| Publisher | : Springer Nature |
| Total Pages | : 587 |
| Release | : |
| Genre | : |
| ISBN | : 9819994624 |
| Author | : Paban K. Agrawala |
| Publisher | : Elsevier |
| Total Pages | : 478 |
| Release | : 2021-08-25 |
| Genre | : Medical |
| ISBN | : 0323856535 |
Epigenetics and Metabolomics, a new volume in the Translational Epigenetics series, offers a synthesized discussion of epigenetic control of metabolic activity, and systems-based approaches for better understanding these mechanisms. Over a dozen chapter authors provide an overview of epigenetics in translational medicine and metabolomics techniques, followed by analyses of epigenetic and metabolomic linkage mechanisms likely to result in effective identification of disease biomarkers, as well as new therapies targeting the removal of the inappropriate epigenetic alterations. Epigenetic interventions in cancer, brain damage, and neuroendocrine disease, among other disorders, are discussed in-depth, with an emphasis on exploring next steps for clinical translation and personalized healthcare. - Offers a synthesized discussion of epigenetic regulation of metabolic activity and systems-based approaches to power new research - Discusses epigenetic control of metabolic pathways and possible therapeutic targets for cancer, neurodegenerative, and neuroendocrine diseases, among others - Provides guidance in epigenomics and metabolomic research methodology
| Author | : Institute of Medicine |
| Publisher | : National Academies Press |
| Total Pages | : 354 |
| Release | : 2012-09-13 |
| Genre | : Science |
| ISBN | : 0309224187 |
Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.
