Peripheral Markers Of Immune Response In Major Psychiatric Disorders Where Are We Now And Where Do We Want To Be
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| Author | : Błażej Misiak |
| Publisher | : Frontiers Media SA |
| Total Pages | : 115 |
| Release | : 2019-04-03 |
| Genre | : |
| ISBN | : 2889457974 |
Major psychiatric disorders, including schizophrenia, bipolar disorder and major depression represent complex phenotypes with imprecise diagnostic boundaries. It has been found that these disorders can be characterized by a number of peripheral immune-inflammatory alterations, including, i.e. elevated levels of pro-inflammatory cytokines, increased levels of specific and non-specific antibodies or abnormal counts of lymphocyte subpopulations. Although it has been found that major psychiatric disorders share similar dysregulations of immune-inflammatory response, recent studies have also clearly demonstrated that some differences can be indicated. Interestingly, certain immune-inflammatory disturbances appear to be state markers, since they occur in acute relapse and normalize following pharmacological treatment, while the rest represents trait markers that remain stable regardless of treatment. It is also important to note that peripheral immune-inflammatory markers have been associated with psychopathological manifestation of major psychiatric disorders, response to treatment and long-term outcomes. However, it remains unclear what is the origin of peripheral inflammation in psychiatric disorders. To date, several mechanisms have been proposed, including the gut-brain axis dysregulation, infections in the neurodevelopmental period or immunogenetic factors. This eBook summarizes current evidence from studies investigating peripheral inflammation in schizophrenia, bipolar disorder, major depression and post-traumatic stress disorder as well as it provides future directions for the field.
| Author | : Jiucun Wang |
| Publisher | : Frontiers Media SA |
| Total Pages | : 485 |
| Release | : 2020-12-21 |
| Genre | : Science |
| ISBN | : 2889661849 |
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
| Author | : Marion Leboyer |
| Publisher | : Frontiers Media SA |
| Total Pages | : 124 |
| Release | : 2020-10-09 |
| Genre | : Medical |
| ISBN | : 2889660567 |
| Author | : Dagmar Sternad |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 727 |
| Release | : 2008-12-25 |
| Genre | : Medical |
| ISBN | : 038777064X |
This ground-breaking book brings together researchers from a wide range of disciplines to discuss the control and coordination of processes involved in perceptually guided actions. The research area of motor control has become an increasingly multidisciplinary undertaking. Understanding the acquisition and performance of voluntary movements in biological and artificial systems requires the integration of knowledge from a variety of disciplines from neurophysiology to biomechanics.
| Author | : G. Hemmings |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 270 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 9401162069 |
For years lip service has been paid to a belief in a biological basis for schizophrenia, but ,nevertheless psychosocial and psychodynamic "theories" of schizophrenia have been promulgated, and these have detracted from the all important biological work, Eclecticism has ruled the day and has caused considerable confusion, As a result research in schizophrenia has not progressed as fast as it should have done and treatment has been less effective than it could otherwise have been. This book is devoted to a wholly biological approach to the problem of schizophrenia, in the hope that many more workers will enter this exciting field of research. A wide variety of topics is covered, including brain structure; the genetics, pathogenesis and treatment of schizophrenia; a consideration of dietary and immunological factors and finally a chapter on alcoholism as it seems possible that the problems of schizophrenia and addiction are linked. We are grateful to all our contributors and to MTP Press for their enthusiasm for this book. Gwynneth P Hemmings William A Hemmings XI SECTION 1: Structure 1 The brain stem reticular formation K. E. WEBSTER There can be no question that the brain stem reticular lormation no longer exercises the same fascination for neurologists that it did a quarter of a century ago.
| Author | : Michael Berk |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2021 |
| Genre | : |
| ISBN | : 9783030712303 |
This book presents a thorough and critical review of current knowledge on the role of immunology in major psychiatric disorders and its potential applications. The opening chapters offer general information on the immune influence of the brain to provide readers with a better understanding of the end of immune privilege. The book then examines possible underlying mechanisms leading to psychiatric disorders, from early infections to pro-inflammatory markers, stress, and immune genetic background, linking etiology and psychiatry. The third section describes each disorder (ie autism, schizophrenia, bipolar disorder, depression...) with an overview of underlying immune dysfunctions. Lastly, the authors discuss the innovative immune-therapies that may result from the discovery of immune system biomarkers and their associated mechanisms. A better understanding of the role of the immune system in psychiatric disorders makes it possible to identify stratification biomarkers, to explain underlying mechanisms, and to develop innovative, efficient, targeted treatment strategies and management. As such, the book is of value to clinicians, mental health professionals, mental health researchers, immunologists, industry practitioners, and various stakeholders in the mental health field.
| Author | : Firas H. Kobeissy |
| Publisher | : CRC Press |
| Total Pages | : 718 |
| Release | : 2015-02-25 |
| Genre | : Medical |
| ISBN | : 1466565993 |
With the contribution from more than one hundred CNS neurotrauma experts, this book provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma including biomarker studies, experimental models, diagnostic methods, and neurotherapeutic intervention strategies in brain injury research. It discusses neurotrauma mechanisms, biomarker discovery, and neurocognitive and neurobehavioral deficits. Also included are medical interventions and recent neurotherapeutics used in the area of brain injury that have been translated to the area of rehabilitation research. In addition, a section is devoted to models of milder CNS injury, including sports injuries.
| Author | : |
| Publisher | : Elsevier |
| Total Pages | : 609 |
| Release | : 2008-06-18 |
| Genre | : Science |
| ISBN | : 0080559352 |
This book opens a new page of neuro-immunobiology providing substantive experimental and clinical data to support current understanding in the field, and potential applications of this knowledge in the treatment of disease. The volume is a collection of complex, new data drawn from multiple areas of investigation in the field. The contents summarize current understanding on the presence and function of CNS cytokines and their receptors in a variety of CNS cells during health and disease. The chapters are a collection of complex, new data demonstrating the presence and synthesis of cytokines in brain cells, as well as their receptors on cell membranes in health and disease. The strength of the volume are the descriptions of the authors own investigations, together with those of others in the field pertaining to a large number of cytokines in brain function, as well as mechanisms involved in the development of CNS disorders, including multiple sclerosis and Alzheimer's disease. Also included are novel approaches to the treatment of CNS disorders based on new experimental data. The contributors to this volume are internationally known scientists and clinical researchers in their respective fields of investigation and treatment.*Opens a new page of neuro-immunobiology and provides substantive evidence for the promise of this field in the treatment of disease*Summarizes current understanding on the presence and function of central nervous system (CNS) cytokines and their receptors in a variety of CNS cells during health and disease*Includes novel approaches to the treatment of CNS disorders based on new experimental data*Offers new insight into triggers for the development of autoimmune diseases in the brain and the possibilities for treatment
| Author | : Arie Kaffman |
| Publisher | : Frontiers Media SA |
| Total Pages | : 247 |
| Release | : 2021-12-01 |
| Genre | : Science |
| ISBN | : 2889717577 |
| Author | : |
| Publisher | : |
| Total Pages | : 8 |
| Release | : 1991 |
| Genre | : Post-traumatic stress disorder |
| ISBN | : |
