Peptides In Oncology Iii
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| Author | : K. Höffken |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 132 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 3642595871 |
Interference with protein-mediated intra- and intercellular pathways has become a major goal of preclinical and clinical research. A, rapidly increasing numBer of peptides are known to be responsible for endo-, para-and autocrine sig nal transduction. These peptides and their receptors have been studied with regard to their cell growth stimulatory ac tion and their impact on differentiation. In parallel, peptide antagonists are being investigated in terms of their potential role in preclinical and clinical application. Thus, biotherapy might improve the clinical outcome of patients with tumors that respond to the respective hormonal manipulation. Among the numerous peptides of interest somatostatin (somatotropin release inhibitory factor) and the luteinizing hormone releasing hormone (LH-RH) have been the topic of intensive research during recent years. In this third vol ume of peptides in oncology, experts in the field exten sively review and update the mechanisms of action of so matostatin and LH -RH -analogues in oncology. Somatostatin and its various short-and long-acting ana logues have the unique feature of suppressing and inhibit ing a wide range of cellular processes including cell prolif eration. Receptors for these peptides which belong to the family of neuropeptides or neurotransmitters, are widely distributed, a feature which is not in keeping with the gen eral view of a growth hormone regulatory system. LH -RH analogues play an established role in curative (adjuvant) and palliative treatment of hormone sensitive tumors."
| Author | : Alicja Hubalewska-Dydejczyk |
| Publisher | : John Wiley & Sons |
| Total Pages | : 379 |
| Release | : 2015-06-11 |
| Genre | : Science |
| ISBN | : 111903163X |
Featuring chapters from specialists in endocrinology, physiology, pathology, and nuclear medicine, this book provides a multidisciplinary approach to a wide variety of issues concerning somatostatin and its analogues. The book: Provides the most up-to-date coverage of somatostatin analog use in diagnostic and therapy Integrating the specialties of endocrinology, physiology, pathology, and nuclear medicine, providing the multidisciplinary approach to the topic Focuses on future applications, novel compounds, and areas for further research Covers topics by authors who are renowned experts and researchers in the field
| Author | : Manfred Schwab |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 1017 |
| Release | : 2001-10-15 |
| Genre | : Medical |
| ISBN | : 3540665277 |
This comprehensive encyclopedic reference provides rapid and focused information about topics of cancer research for the clinical and basic scientist, students and informed laymen. It will be readily accessible, both electronically and in print, such that it will be of value to both the scientific community and the public.
| Author | : Malay K. Das |
| Publisher | : Academic Press |
| Total Pages | : 428 |
| Release | : 2021-03-16 |
| Genre | : Medical |
| ISBN | : 0128217006 |
Multifunctional Theranostic Nanomedicines in Cancer focuses on new trends, applications, and the significance of novel multifunctional nanotheranostics in cancer imaging for diagnosis and treatment. Cancer nanotechnology offers new opportunities for cancer diagnosis and treatment. Multifunctional nanoparticles harboring various functions—including targeting, imaging, and therapy—have been intensively studied with the goal of overcoming the limitations of conventional cancer diagnosis and therapy. Thus theranostic nanomedicines have emerged in recent years to provide an efficient and safer alternative in cancer management. This book covers polymer-based therapies, lipid-based therapies, inorganic particle-based therapies, photo-related therapies, radiotherapies, chemotherapies, and surgeries. Multifunctional Theranostic Nanomedicines in Cancer offers an indispensable guide for researchers in academia, industry, and clinical settings; it is also ideal for postgraduate students; and formulation scientists working on cancer. - Provides a comprehensive resource of recent scientific progress and novel applications of theranostic nanomedicines - Discusses treatment options from a pharmaceutical sciences perspective - Includes translational science and targeted CNS cancer treatment
| Author | : Ved Srivastava |
| Publisher | : Royal Society of Chemistry |
| Total Pages | : 589 |
| Release | : 2017-06-26 |
| Genre | : Medical |
| ISBN | : 1782627324 |
With potentially high specificity and low toxicity, biologicals offer promising alternatives to small-molecule drugs. Peptide therapeutics have again become the focus of innovative drug development efforts backed up by a resurgence of venture funds and small biotechnology companies. What does it take to develop a peptide-based medicine? What are the key challenges and how are they overcome? What are emerging therapeutics for peptide modalities? This book answers these questions with a holistic story from molecules to medicine, combining the themes of design, synthesis and clinical applications of peptide-based therapeutics and biomarkers. Chapters are written and edited by leaders in the field from industry and academia and they cover the pharmacokinetics of peptide therapeutics, attributes necessary for commercially successful metabolic peptides, medicinal chemistry strategies for the design of peptidase-resistant peptide analogues, disease classes for which peptide therapeutic are most relevant, and regulatory issues and guidelines. The critical themes covered provide essential background information on what it takes to develop peptide-based medicine from a chemistry perspective and views on the future of peptide drugs. This book will be a valuable resource not only as a reference book for the researcher engaged in academic and pharmaceutical setting, from basic research to manufacturing and from organic chemistry to biotechnology, but also a valuable resource to graduate students to understand discovery and development process for peptide-based medicine.
| Author | : Katsumi Matsuzaki |
| Publisher | : Springer |
| Total Pages | : 300 |
| Release | : 2019-04-12 |
| Genre | : Medical |
| ISBN | : 9811335885 |
This book presents an overview of antimicrobial peptides (AMPs), their mechanisms of antimicrobial action, other activities, and various problems that must still be overcome regarding their clinical application. Divided into four major parts, the book begins with a general overview of AMPs (Part I), and subsequently discusses the various mechanisms of antimicrobial action and methods for researching them (Part 2). It then addresses a range of activities other than antimicrobial action, such as cell penetration, antisepsis, anticancer, and immunomodulatory activities (Part 3), and explores the prospects of clinical application from various standpoints such as the selective toxicity, design, and discovery of AMPs (Part 4). A huge number of AMPs have been discovered in plants, insects, and vertebrates including humans, and constitute host defense systems against invading pathogenic microorganisms. Consequently, many attempts have been made to utilize AMPs as antibiotics. AMPs could help to solve the urgent problem of drug-resistant bacteria, and are also promising with regard to sepsis and cancer therapy. Gathering a wealth of information, this book will be a bible for all those seeking to develop antibiotics, anti-sepsis, or anticancer agents based on AMPs.
| Author | : Burzynski Research Institute |
| Publisher | : |
| Total Pages | : 48 |
| Release | : 1988 |
| Genre | : |
| ISBN | : 9783609631004 |
| Author | : Katsunori Tanaka |
| Publisher | : John Wiley & Sons |
| Total Pages | : 560 |
| Release | : 2020-04-27 |
| Genre | : Science |
| ISBN | : 3527344322 |
Provides timely, comprehensive coverage of in vivo chemical reactions within live animals This handbook summarizes the interdisciplinary expertise of both chemists and biologists performing in vivo chemical reactions within live animals. By comparing and contrasting currently available chemical and biological techniques, it serves not just as a collection of the pioneering work done in animal-based studies, but also as a technical guide to help readers decide which tools are suitable and best for their experimental needs. The Handbook of In Vivo Chemistry in Mice: From Lab to Living System introduces readers to general information about live animal experiments and detection methods commonly used for these animal models. It focuses on chemistry-based techniques to develop selective in vivo targeting methodologies, as well as strategies for in vivo chemistry and drug release. Topics include: currently available mouse models; biocompatible fluorophores; radionuclides for radiodiagnosis/radiotherapy; live animal imaging techniques such as positron emission tomography (PET) imaging; magnetic resonance imaging (MRI); ultrasound imaging; hybrid imaging; biocompatible chemical reactions; ligand-directed nucleophilic substitution chemistry; biorthogonal prodrug release strategies; and various selective targeting strategies for live animals. -Completely covers current techniques of in vivo chemistry performed in live animals -Describes general information about commonly used live animal experiments and detection methods -Focuses on chemistry-based techniques to develop selective in vivo targeting methodologies, as well as strategies for in vivo chemistry and drug release -Places emphasis on material properties required for the development of appropriate compounds to be used for imaging and therapeutic purposes in preclinical applications Handbook of In Vivo Chemistry in Mice: From Lab to Living System will be of great interest to pharmaceutical chemists, life scientists, and organic chemists. It will also appeal to those working in the pharmaceutical and biotechnology industries.
| Author | : K. Höffken |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 202 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 3642849563 |
This second of two volumes presents the state of the art in somatostatin analogues and bombesin antagonists in neoplastic diseases. It provides a detailed description of mechanisms of action and the present clinical relevance of these new approaches in cancer treatment. Each chapter has been prepared by an expert active in the respective experimental and/or clinical field so that the reader is assured of obtaining the latest information on the topic.
| Author | : Emilio Bombardieri |
| Publisher | : CRC Press |
| Total Pages | : 534 |
| Release | : 2007-10-15 |
| Genre | : Medical |
| ISBN | : 0203089677 |
The diagnostic and therapeutic achievements in radiopharmaceuticals and nuclear medicine instrumentation - PET, SPECT, MR, CT and their hypbrids PET-CT and SPECT-CT - are the result of the interdisciplinary research efforts of cell-biologists, chemists, pharmacologists, physicists, computer-scientists, engineers, nuclear medicine physicians, a
