Organotitanium Reagents in Organic Synthesis

Organotitanium Reagents in Organic Synthesis
Author: Manfred T. Reetz
Publisher: Springer Science & Business Media
Total Pages: 244
Release: 2013-11-11
Genre: Science
ISBN: 3642707041

Titanium has been used to perform many kinds of reactions in organic and inorganic chemistry. The present book is concerned primarily with a new development in titanium chemistry which is useful in organic synthesis. In 1979/80 it was discovered that the titanation of classical carbanions using C1TiX leads to species with reduced basicity and reactivity. This increases 3 chemo-, regio-and stereo selectivity in reactions with organic compounds such as aldehydes, ketones and alkyl halides. Many new examples have been reported in recent times. Since the nature of the ligand X at titanium can be widely varied, the electronic and steric nature of the reagents is easily controlled. This helps in predicting the stereochemical outcome of many of the C-C bond forming reactions, but the trial and error method is still necessary in other cases. One of the ultimate objectives of chemistry is to understand correlations between structure and reactivity. Although this goal has not been reached in the area of organotitanium chemistry, appreciable progress has been made. A great deal of physical and computational data of organotitanium compounds described in the current and older literature (e. g. , Ziegler-Natta type catalysts) has been reported by polymer, inorganic and theoretical chemists. It is summarized in Chapter 2 of this book, because some aspects are useful in understanding reactivity and selectivity of organo titanium compounds in organic synthesis as described in the chapters which follow.

Organometallics in Process Chemistry

Organometallics in Process Chemistry
Author: Ahmed F. Abdel-Magid
Publisher: Springer Science & Business Media
Total Pages: 316
Release: 2004-06-15
Genre: Science
ISBN: 9783540016038

The design of efficient syntheses of medicinal agents is one of the prime goals of the process chemist in the pharmaceutical industry. The expanding list of metal-mediated reactions has had a major impact on this endeavor over the last two decades. This volume will highlight some of the areas of organometallic chemistry that have played a particularly important role in development. The chapters are written by chemists who work in the process groups of major pharmaceutical companies and fine chemical manufacturers. Having demonstrated the power of organometallics in their processes the authors herein expand upon their experiences with examples from the literature as reported by process groups within the industry. The chapters are organized either by the application of a particular metal or reaction class. Removal of the residual metal(s) from the isolated active pharmaceutical ingredient (API) is key to the release of the material for human consumption, and hence, is reviewed here as well. This volume of Topics in Organometallic Chemistry is presented to offer a representative cross section of organometallic applications in the pharmaceutical industry as well as to give an appreciation for the creativity possible in process chemistry.

Modern Organic Synthesis

Modern Organic Synthesis
Author: George S. Zweifel
Publisher: John Wiley & Sons
Total Pages: 416
Release: 2017-03-13
Genre: Science
ISBN: 1119086760

This book bridges the gap between sophomore and advanced / graduate level organic chemistry courses, providing students with a necessary background to begin research in either an industry or academic environment. • Covers key concepts that include retrosynthesis, conformational analysis, and functional group transformations as well as presents the latest developments in organometallic chemistry and C–C bond formation • Uses a concise and easy-to-read style, with many illustrated examples • Updates material, examples, and references from the first edition • Adds coverage of organocatalysts and organometallic reagents

Fieser and Fieser's Reagents for Organic Synthesis, Volume 14

Fieser and Fieser's Reagents for Organic Synthesis, Volume 14
Author: Mary Fieser
Publisher: John Wiley & Sons
Total Pages: 405
Release: 1989-08-21
Genre: Science
ISBN: 0471504009

This ongoing series, originated in 1967, has become the standard guide to the preparation, properties and uses of thousands of reagents, and additional references to reagents previously discussed. It includes data on structural formulae, molecular weight, physical constants, preferred method of preparation, and examples of important uses. It also contains data on commonly used reagents from 1966 to 1988.

Organometallics in Synthesis

Organometallics in Synthesis
Author: Manfred Schlosser
Publisher: John Wiley & Sons
Total Pages: 1028
Release: 2013-04-15
Genre: Science
ISBN: 047012217X

WINNER of the 2013 PROSE Award in Chemistry & Physics This latest edition enables readers to master new classes of organometallic compounds and syntheses A popular resource used by synthetic organic chemists around the world, this book enables readers to conduct seamless synthetic reactions involving key organometallics. Each reaction is set forth in the book's acclaimed recipe-style format so that readers can easily replicate the results in their own labs. Moreover, each chapter has been written by a world leader in the field of organometallics in organic synthesis. These authors offer hands-on guidance and practical examples illustrating the preparation of organometallics and its application in organic synthesis. This Third Manual of Organometallics in Synthesis features completely new content and topics, with an eye towards providing researchers with the most useful and practical reference on the synthesis of organometallics. Organized into chapters by type of organometallic compound, the book covers: Organoalkali chemistry Organomagnesium and organozinc chemistry Organosilicon and relating organotin chemistry Organoiron chemistry Organopalladium chemistry Within each chapter, readers will find background information to learn more about the class of organometallics as well as mechanistic considerations. The authors thoroughly discuss the various methods of preparing the organometallic compounds presented in the book and outline their uses in synthetic reactions. In addition to current applications, the authors explore future research opportunities for each organometallic class. References at the end of each chapter enable readers to explore all the topics in greater depth. More and more industrial processes rely on organometallic chemistry. As a result, readers will find this book's step-by-step instructions essential in such fields as natural product synthesis, pharmaceuticals, fine chemicals, biotechnology, polymers, and materials science.

Comprehensive Organic Synthesis

Comprehensive Organic Synthesis
Author:
Publisher: Newnes
Total Pages: 9815
Release: 2014-02-14
Genre: Science
ISBN: 008097743X

The second edition of Comprehensive Organic Synthesis—winner of the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers—builds upon the highly respected first edition in drawing together the new common themes that underlie the many disparate areas of organic chemistry. These themes support effective and efficient synthetic strategies, thus providing a comprehensive overview of this important discipline. Fully revised and updated, this new set forms an essential reference work for all those seeking information on the solution of synthetic problems, whether they are experienced practitioners or chemists whose major interests lie outside organic synthesis. In addition, synthetic chemists requiring the essential facts in new areas, as well as students completely new to the field, will find Comprehensive Organic Synthesis, Second Edition, Nine Volume Set an invaluable source, providing an authoritative overview of core concepts. Winner of the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers Contains more than170 articles across nine volumes, including detailed analysis of core topics such as bonds, oxidation, and reduction Includes more than10,000 schemes and images Fully revised and updated; important growth areas—including combinatorial chemistry, new technological, industrial, and green chemistry developments—are covered extensively

Reagents for Organic Synthesis

Reagents for Organic Synthesis
Author: Louis Frederick Fieser
Publisher:
Total Pages: 408
Release: 1967
Genre: Chemical tests and reagents
ISBN:

This major reference work is arranged like an encyclopedia, with each entry providing information about a reagent which has been reported as useful in organic synthesis. Most of the reagents are themselves organic, but inorganic reagents are also included. Suppliers are listed for commercially available reagents; otherwise, a brief indication of the method of preparation is given, along with a literature reference. Concise information and literature references are also provided on the application of reagents. There are author and subject indexes, and a very useful index of reagents by type, so that this reference set can serve as a very convenient point of entry into the literature dealing with a general type of reaction, whether it be a "name" reaction (e.g., Baeyer-Villiger oxidation), a method of introducing a specific functional group (e.g., amination), etc.