Optimal And Predictable Microwave Ablation For Local Cancer Treatment
Download Optimal And Predictable Microwave Ablation For Local Cancer Treatment full books in PDF, epub, and Kindle. Read online free Optimal And Predictable Microwave Ablation For Local Cancer Treatment ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Author | : Sevde Etoz Niemeier |
Publisher | : |
Total Pages | : 0 |
Release | : 2020 |
Genre | : |
ISBN | : |
Microwave ablation is one of the most common minimally invasive targeted cancer treatment technique. Since development phase of the technique resulted in several commercial ablation systems, current research topics include optimization of the current systems and practices. Recent studies have shown that outcomes of microwave ablation can vary patient to patient. To foresee the ablation results, investigation of treatment planning techniques has gained great interest recently. Simulations have been the main tool for the treatment planning process which requires accurate tissue models. In this work, I investigated new simulation approaches to increase microwave ablation simulation accuracy. Chapter 1 provides an introduction to the current state of microwave ablation and the variability of ablation outcomes with the current systems are presented. Potential sources of this variability were discussed. Moreover, the accuracy of microwave ablation simulations was evaluated with ex-vivo studies (experiments and simulations). The study results suggested that current dielectric property models need improvement. Therefore, following chapters focused on the dielectric tissue property model development for liver and lung tissues. In microwave ablation context, tissue properties can be divided into two groups: baseline and temperature dependent temporal changes during heating. Both depends on the constituents of tissues; therefore, dielectric mixture models were used in the development of liver and lung tissue models. Chapter 2 presents tissue models which were tissue water content dependent. It has been assumed that water content was responsible for the drastic changes in dielectric properties during heating. Chapter 3 outlines the techniques for application of the water content dependent dielectric mixture models in the microwave ablation setting. With this study, it was directly shown that vaporization was the most dominant mechanism in dielectric property change at high temperatures, dielectric mixture models can model vapor induced effects, and the proposed approach with the mixture model allowed more accurate dielectric property predictions than the current models in literature. Since this study focused the temporal changes of tissue properties. In the first 3 chapters, temporal changes in dielectric properties were studied. Chapter 4 presents experiments and simulations in phantoms for tissues with ectopic fat storage, which changes the baseline tissue properties. Differences in heating mechanisms in phantoms with varying fat contents were discovered. Moreover, a framework was introduced for imaging-based (magnetic resonance imaging) determination of baseline tissue dielectric properties. Chapter 5 describes lung tissue dielectric property models that have been built with the data that was collected. The aim of this study was to develop an air content tissue model for lung, therefore, concurrent measurements of dielectric properties with open-ended coaxial probe and air content with CT and microCT was included in the model development process. Chapter 6 describes the implementation of the tissue dielectric property model that was developed in the Chapter 2 and 3 in simulations. The results of the simulated ablation zones were compared with the ablation zones that were measured precisely by accounting for the contraction. The simulations with the proposed model had higher accuracy in the prediction of the ablation zone dimensions in ex-vivo tissues. Chapter 6 also included a study on thermal behavior of the liver perfusion. The literature review on perfusion in the thermal ablation area showed the need for a liver specific perfusion model. In-vivo liver ablation temperatures were collected and used as the training data for the optimization of a muscle perfusion model for liver tissue.
Author | : Henry S. Park |
Publisher | : BoD – Books on Demand |
Total Pages | : 226 |
Release | : 2021-06-02 |
Genre | : Medical |
ISBN | : 1789855756 |
Lung cancer continues to be the leading cause of cancer mortality worldwide among both men and women. Recent advances in prevention, screening and management in the past decade have led to significant improvements in survival and quality of life. Local treatments like minimally invasive surgery, radiotherapy, and image-guided ablation have contributed to improving the effectiveness and tolerability of potentially curative treatments in early-stage, locally advanced, and oligometastatic/oligoprogressive disease. Chemotherapy, targeted therapy, immunotherapy, and palliative local therapy options have expanded rapidly, with new regimens showing improved outcomes even for those with widely metastatic disease. This book comprehensively reviews the evidence that has driven personalized medicine, based on a variety of multidisciplinary perspectives by international lung cancer experts.
Author | : C. Stroszczynski |
Publisher | : Springer Science & Business Media |
Total Pages | : 146 |
Release | : 2006-09-09 |
Genre | : Medical |
ISBN | : 3540281371 |
In the age of the World Wide Web, informed patients continue to surprise oncologists with detailed questions about popular tumor therapies. Although minimally invasive tumor therapies (MITT) have become daily clinical practice for palliative treatment of liver tumors, the acceptance of these palliative modalities still varies enormously. This book gives an up-to-date overview of the popular techniques and clinical results of MITT, with a clarification of the actual indications including the size, tumor entities, and clinical benefits. Moreover, the book focuses on the prospectives and limitations of imaging methods used for MITT.
Author | : Sergey N. Makarov |
Publisher | : Springer Nature |
Total Pages | : 395 |
Release | : 2021 |
Genre | : Biomedical engineering |
ISBN | : 3030456234 |
The 41st Annual International Conference of the IEEE EMBS, took place between July 23 and 27, 2019, in Berlin, Germany. The focus was on "Biomedical engineering ranging from wellness to intensive care." This conference provided an opportunity for researchers from academia and industry to discuss a variety of topics relevant to EMBS and hosted the 4th Annual Invited Session on Computational Human Models. At this session, a bevy of research related to the development of human phantoms was presented, together with a substantial variety of practical applications explored through simulation.
Author | : Eric van Sonnenberg |
Publisher | : Springer Science & Business Media |
Total Pages | : 554 |
Release | : 2008-09-08 |
Genre | : Medical |
ISBN | : 0387286748 |
There is an enormous sense of excitement in the communities of cancer research and cancer care as we move into the middle third of the ?rst decade of the 21st century. For the ?rst time,there is a true sense of c- ?dence that the tools provided by the human genome project will enable cancer researchers to crack the code of genomic abnormalities that allow tumor cells to live within the body and provide highly speci?c, virtually non-toxic therapies for the eradication,or at least ?rm control of human cancers. There is also good reason to hope that these same lines of inquiry will yield better tests for screening, early detection, and prev- tion of progression beyond curability. While these developments provide a legitimate basis for much op- mism, many patients will continue to develop cancers and suffer from their debilitating effects, even as research moves ahead. For these in- viduals, it is imperative that the cancer ?eld make the best possible use of the tools available to provide present day cancer patients with the best chances for cure, effective palliation, or, at the very least, relief from symptoms caused by acute intercurrent complications of cancer. A modality that has emerged as a very useful approach to at least some of these goals is tumor ablation by the use of physical or physiochemical approaches.
Author | : Amira S. Ashour |
Publisher | : Elsevier |
Total Pages | : 466 |
Release | : 2021-05-21 |
Genre | : Science |
ISBN | : 0128195444 |
Thermal Ablation Therapy: Theory and Simulation includes detailed theoretical and technical concepts of thermal ablation therapy in different body organs. Concepts of ablation technology based on different thermal ablation methods are introduced, along with changes in the tissues' mechanical properties due to thermal denaturation. The book emphasizes the mathematical and engineering concepts of RF and MW energy propagation through tissues and where high heating rates produced by MW systems can overcome the heat-sink effects from nearby vessels. The design and tuning of the MW antennas to deliver energy efficiently to specific organ systems such as the liver or lung is also covered. Other sections cover the computational modeling of radiofrequency ablation and microwave ablation procedures for developing and implementing new efficient ablation in clinical systems, numerical simulations for different scenarios of different organs with different size using RF and MW ablation systems with different antennas'/probes design and configurations, and numerical techniques for temperature profile in tissues. Presents the latest mathematical models of microwave and RF ablation theories Discusses the biological responses and engineering principles by which thermal ablation techniques can provide temperature-elevation within the organs of the human body, including action mechanisms, required equipment, needle characteristics and treatment techniques Highlights the different techniques of thermal ablation, including radiofrequency ablation, microwave ablation, laser ablation, and ultrasound ablation, nanotechnology, and the different metrics used to evaluate the performance of the used antenna within the ablation needle
Author | : Gerhard J. Müller |
Publisher | : SPIE Press |
Total Pages | : 572 |
Release | : 1995 |
Genre | : Lasers in medicine |
ISBN | : 9780819418593 |
Author | : Boris Rubinsky |
Publisher | : Springer Science & Business Media |
Total Pages | : 320 |
Release | : 2009-11-25 |
Genre | : Technology & Engineering |
ISBN | : 364205420X |
Non-thermal irreversible electroporation is a new minimally invasive surgical p- cedure with unique molecular selectivity attributes – in fact it may be considered the first clinical molecular surgery procedure. Non-thermal irreversible electro- ration is a molecular selective mode of cell ablation that employs brief electrical fields to produce nanoscale defects in the cell membrane, which can lead to cell death, without an effect on any of the other tissue molecules. The electrical fields can be produced through contact by insertion of electrode needles around the undesirable tissue and non-invasively by electromagnetic induction. This new - dition to the medical armamentarium requires the active involvement and is of interest to clinical physicians, medical researchers, mechanical engineers, che- cal engineers, electrical engineers, instrumentation designers, medical companies and many other fields and disciplines that were never exposed in their training to irreversible electroporation or to a similar concept. This edited book is designed to be a comprehensive introduction to the field of irreversible electroporation to those that were not exposed or trained in the field before and can also serve as a reference manual. Irreversible electroporation is broad and interdisciplinary. Therefore, we have made an attempt to cover every one of the various aspects of the field from an introductory basic level to state of the art.
Author | : Adam E. M. Eltorai |
Publisher | : Springer Nature |
Total Pages | : 545 |
Release | : 2019-12-18 |
Genre | : Medical |
ISBN | : 3030260445 |
The book is an on-the-spot reference for residents and medical students seeking diagnostic radiology fast facts. Its question-and-answer format makes it a perfect quick-reference for personal review and studying for board examinations and re-certification. Readers can read the text from cover to cover to gain a general foundation of knowledge that can be built upon through practice or can use choice chapters to review a specific subspecialty before starting a new rotation or joining a new service. With hundreds of high-yield questions and answer items, this resource addresses both general and subspecialty topics and provides accurate, on-the-spot answers. Sections are organized by subspecialty and body area, including chest, abdomen, and trauma, and chapters cover the anatomy, pathophysiology, differential diagnosis, hallmark signs, and image features of major diseases and conditions. Key example images and illustrations enhance the text throughout and provide an ideal, pocket-sized resource for residents and medical students.
Author | : Kecheng Xu |
Publisher | : World Scientific |
Total Pages | : 940 |
Release | : 2012-04-26 |
Genre | : Medical |
ISBN | : 9814462470 |
Cryosurgery is a surgical technique that employs freezing to destroy undesirable tissue. From as early as 3500 BC, there is evidence for the use of cold in medicine for the treatment of infected wounds of the chest, fracture of the skull and various injuries. However, the history of “modern” cryosurgery is relatively short and is closely intertwined with the development in low temperature physics, engineering, and instrumentation during the last century.From the early 21st century, advanced helium-based cryosurgery has been applied worldwide. More than ten thousand patients with malignant and benign tumors have received cryosurgery. It is specially noted that in most cases cryosurgery, as a mini-invasive ablation technique, was performed with percutaneous approach under guidance of CT or ultrasound. Cryosurgery is now one of the more popular techniques in China, with nearly 6000 cases of tumors receiving cryosurgery in the author's institution alone. This book summarizes the experimental and clinical experience and practice of cryosurgery, and describes the basics of cryosurgery and its use in the treatment of various tumors.