Webvision

Webvision
Author: Helga Kolb
Publisher:
Total Pages:
Release: 2007
Genre:
ISBN:

MAP Kinase Signaling Protocols

MAP Kinase Signaling Protocols
Author: Rony Seger
Publisher: Humana Press
Total Pages: 530
Release: 2010-09-10
Genre: Science
ISBN: 9781607617945

Mitogen-activated protein (MAP) kinase (MAPK) cascades are key signaling components that govern essentially all cellular processes evoked by any type of stimulation, and it has been well established that the malfunctioning of these cascades leads to various diseases including cancer, autoimmunity, and diabetes. In MAP Kinase Signaling Protocols, Second Edition, expert researchers fully update the popular first edition the key techniques used in the study of MAPK signaling cascades in various cellular contexts. This thorough volume explores essential topics such as activation and function of components of the MAPK signaling cascades, the study of MAPK cascades as transmitters of membranal receptor signals, structure-function relationships of MAPKs, studies on the regulation of MAPK cascades, the use of lower organisms, animal models, and human genetics in the study of MAPKs, as well as the study of MAPKs in specific systems and diseases. Written in the highly successful Methods in Molecular BiologyTM series format, chapters includes introductions to their respective subjects, lists of the necessary materials, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, MAP Kinase Signaling Protocols, Second Edition aims to facilitate the study of MAPKs and allow for quicker progress in our knowledge of many vital cellular processes as well as devastating diseases.

Cajal's Degeneration and Regeneration of the Nervous System

Cajal's Degeneration and Regeneration of the Nervous System
Author: Santiago Ramón y Cajal
Publisher: History of Neuroscience
Total Pages: 977
Release: 1991
Genre: Nervous system
ISBN: 0195065166

This book is a reprint of an English translation of Cajal's original work, with abundant notes and commentaries by the editor. This text describes Cajal's fundamental contributions to neuroscience, which continue to be important today. It accurately details Cajal's ideas and data, and providesreaders with the opportunity to learn what Cajal thought about his research career and the significance of his observations. Excerpts from Tello's memorial lectures also provide a contemporary view of Cajal's work.

Neural Regeneration

Neural Regeneration
Author: Kwok Fai So
Publisher: Academic Press
Total Pages: 449
Release: 2015-02-03
Genre: Science
ISBN: 0128018348

Neural Regeneration provides an overview of cutting-edge knowledge on a broad spectrum of neural regeneration, including: - Neural regeneration in lower vertebrates - Neural regeneration in the peripheral nervous system - Neural regeneration in the central nervous system - Transplantation-mediated neural regeneration - Clinical and translational research on neural regeneration The contributors to this book are experts in their fields and work at distinguished institutions in the United States, Canada, Australia, and China. Nervous system injuries, including peripheral nerve injuries, brain and spinal cord injuries, and stroke affect millions of people worldwide every year. As a result of this high incidence of neurological injuries, neural regeneration and repair is becoming a rapidly growing field dedicated to the new discoveries to promote structural and functional recoveries based on neural regeneration. The ultimate goal is to translate the most optimal regenerative strategies to treatments of human nervous system injuries. This valuable reference book is useful for students, postdoctors, and basic and clinical scientists who are interested in neural regeneration research. - Provides an overview of cutting-edge knowledge on a broad spectrum of neural regeneration - Highly translational and clinically-relevance - International authors who are leaders in their respective fields - Vivid art work making the chapters easily understood

Degeneration and Regeneration in the Nervous System

Degeneration and Regeneration in the Nervous System
Author: Norman Saunders
Publisher: CRC Press
Total Pages: 354
Release: 2003-09-02
Genre: Medical
ISBN: 0203304489

Degeneration and Regeneration in the Nervous System brings together an international team of contributors to produce a series of critical reviews appraising key papers in the field. The pace of research on brain and spinal cord injury quickened considerably in the last ten years and there is much that is new and important that is covered in this book. However, there is still a long way to go before our knowledge will explain fully why the central nervous system has such a limited capacity for regeneration, and before experimental solutions can be applied to the patient. With emphasis on actual and therapeutic importance of the work reviewed, Degeneration and Regeneration in the Nervous System is a useful overview for graduate students, their teachers and researchers working in this field.

Principles and Practice of Clinical Electrophysiology of Vision, second edition

Principles and Practice of Clinical Electrophysiology of Vision, second edition
Author: John R. Heckenlively
Publisher: MIT Press
Total Pages: 1033
Release: 2006-04-07
Genre: Medical
ISBN: 0262083469

The long-awaited second edition of an authoritative reference on electrophysiologic vision testing, including detailed information on techniques and problems, basic physiology and anatomy, theoretical concepts, and clinical findings; with extensive new material. This authoritative text is the only comprehensive reference available on electrophysiologic vision testing, offering both practical information on techniques and problems as well as basic physiology and anatomy, theoretical concepts, and clinical correlations. The second edition, of the widely used text, offers extensive new material and updated information: 65 of the 84 chapters are completely new, with the changes reflecting recent advances in the field. The book will continue to be an essential resource for practitioners and scholars from a range of disciplines within vision science. The contributions not only cover new information—important material that is likely to become more important in the next decade—but also offer a long-range perspective on the field and its remarkable development in the last century. After discussing the history and background of clinical electrophysiology, the book introduces the anatomy of the retina and principles of cell biology in the visual pathways at the molecular, physiological, and biochemical levels. It relates these new findings to the techniques and interpretations of clinical tests, including the electro-oculogram (EOG), electroretinogram (ERG), and visual evoked potentials (VEP), which are discussed in detail, as are equipment, data acquisition and analysis, principles and protocols for clinical testing, diseases and dysfunction, and animal testing. Notable additions for this edition include chapters on the origin of electroretinogram waveforms, multifocal techniques, testing in standard laboratory animals, recent advances in analysis of abnormalities in disease, and the applications of these techniques to the study of genetic abnormalities.

Animal Models for Stem Cell Therapy

Animal Models for Stem Cell Therapy
Author: Bruno Christ
Publisher: Humana Press
Total Pages: 0
Release: 2014-09-01
Genre: Science
ISBN: 9781493914524

In Animal Models for Stem Cell Therapy: Methods and Protocols, expert researchers in the field detail disease models of hepatic, cardiovascular, neurological diseases, connective and contractile tissue. Chapters focus on a wide range of diseases and application of different kinds of stem cells and reprogrammed tissue cells (iPS). Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Animal Models for Stem Cell Therapy: Methods and Protocols, covers interest of basic scientists and clinicians to assess the biological as well as the therapeutic potential of stem cell therapy.

Ocular Neuroprotection

Ocular Neuroprotection
Author: Leonard Levin
Publisher: CRC Press
Total Pages: 336
Release: 2003-07
Genre: Medical
ISBN: 0824756134

Ocular neuroprotection is aimed at protecting the death of photoreceptors, retinal ganglion, or other important neurons in cases of disease or trauma. Levin (ophthalmology and neurology, U. of Wisconsin at Madison, US) and Di Polo (pathology and cell biology, U. of Montreal, Canada) present 18 chapt.

Neuronal Degeneration and Regeneration: From Basic Mechanisms to Prospects for Therapy

Neuronal Degeneration and Regeneration: From Basic Mechanisms to Prospects for Therapy
Author: F.W. Van Leeuwen
Publisher: Elsevier
Total Pages: 551
Release: 1998-11-09
Genre: Psychology
ISBN: 008086242X

This book is the result of the 20th International Summer School in Brain Research, organized in August 1997 in Amsterdam, by the Netherlands Institute for Brain Research at the Royal Netherlands Academy of Sciences. It is the first book that provides a complete overview of the field of neurodegeneration and regeneration including spinal cord injury, neurodegenerative diseases and therapy. Divided into five sections, the first two sections give an overview of fundamental research on nerve cell death, neuronal survival, neurite outgrowth and guidance. Extensive attention is given to the role of neurotrophins, their receptor tyrosine kinases and cell-adhesion molecules in development and regeneration of the nervous system. The third section of the book is devoted to research involving human neurodegenerative diseases and emerging treatment strategies. Section four focusses on recent advances in the understanding of pathophysiological mechanisms underlying neurodegenerative diseases, including Alzheimer's, Parkinson's and Huntington's diseases along with prion diseases. Novel insights into the neuropathological hallmarks of these diseases, as well as into transgenic animal models, the involvement of environmental factors, and genomic and mRNA changes that can cause neurodegeneration. The final section of this volume reveals recent developments in the use of cell and gene therapy to treat neurodegenerative disease and lesion-related deficits. Implantation of genetically modified cells, direct gene transfer with viral vectors and the first clinical trials with encapsulated genetically modified cells in patients suffering from amyotrophic lateral scelerosis are examples of new therapeutic strategies treating neurodegenerative diseases.The book is of particular interest to departments of neuroscience, neurological clinics and departments, the pharmalogical industry and medical libraries.