The book gathers some papers concerning the dialogue between neuroscience and psychoanalysis. Following the Introduction written by Georg Northoff, concerning the possibility of overcoming the highly impasse generating contraposition between localizationism and holism, G. Vaslamatzis deals with a “Framework for a new dialogue between psychoanalysis and neurosciences”. In this chapter the author describes three points of epistemological congruence: firstly, dualism is no longer a satisfactory solution; secondly, cautions for the centrality of interpretation (hermeneutics); and, thirdly, the self-criticism of neuroscientists. David W.Mann in his contribution “The mirror crack’d: dissociation and reflexivity in self and group phenomena” tries to show how reflexive processes generate each of three levels of the human system (self, relationships, group) and integrate them one to another, while dissociative processes tend throughout to pull them apart. Health and illness within the self, the relationship and the group can be understood as special states of the dynamic equilibria between these cohesive and dispersive trends. In “Sleep, memory and plasticity” Matthew P. Walker and Robert Stickgold outline a review of the researches following the discovery of rapid eye movement (REM) and non-REM (NREM) sleep, and specifically of those that began testing the hypothesis that sleep, or even specific stages of sleep, actively participated in the process of memory development. The last two chapters, “Clinical implications of neuroscience research in PTSD” by Bessel A. Van Der Kolk, and “Dysregulation of the right brain: a fundamental mechanism of traumatic attachment and the psychopathogenesis of PTSD” by Allan N. Schore, demonstrate how the psychopathology of traumatic conditions can be a fertile field of dialogue between neuroscience and psychoanalysis.