Oecd Series On Testing And Assessment Guiding Principles And Key Elements For Establishing A Weight Of Evidence For Chemical Assessment
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Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 37 |
Release | : 2019-10-22 |
Genre | : |
ISBN | : 9264696814 |
This document is intended to provide universal Guiding Principles that should be considered when developing or augmenting systematic approaches to Weight of Evidence (WoE) for chemical evaluation and Key Elements to formulating a systematic approach to WoE. The ultimate goal is to facilitate that regulators follow a consistent, clear and transparent delivery of evidence using the Principles and Elements described in this document. This can be especially helpful for countries with no existing WoE frameworks or those looking to augment their approaches. It also allows for stakeholders to understand a WoE decision-making process, including potential for unreasonable bias. These Guiding Principles and Key Elements can be employed to develop frameworks that range from simple and pragmatic approaches to more elaborate systems, depending on the context.
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 85 |
Release | : 2017-04-13 |
Genre | : |
ISBN | : 9264274790 |
In this document the importance of mechanistic consideration in quantitative structure-activity relationship ((Q)SAR) analysis, the critical role of mechanistic consideration in improving various (Q)SAR approaches and possible integrative approaches of combining chemoinformatics and ...
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 147 |
Release | : 2023-10-12 |
Genre | : |
ISBN | : 926434828X |
Endocrine disrupting chemicals (EDCs) are contaminants of emerging environmental and health concern that have been detected in freshwater, wastewater and drinking water. They interfere with the endocrine system in humans and wildlife, and produce adverse effects such as developmental, reproductive, neurological and immune effects.
Author | : Dennis J. Paustenbach |
Publisher | : John Wiley & Sons |
Total Pages | : 1319 |
Release | : 2024-04-15 |
Genre | : Technology & Engineering |
ISBN | : 111974296X |
Understand the fundamentals of human risk assessment with this introduction and reference Human risk assessments are a precondition for virtually all industrial action or environmental regulation, all the more essential in a world where chemical and environmental hazards are becoming more abundant. These documents catalog potential environmental, toxicological, ecological, or other harms resulting from a particular hazard, from chemical spills to construction projects to dangerous workplaces. They turn on a number of variables, of which the most significant is the degree of human exposure to the hazardous agent or process. Human and Ecological Risk Assessment combines the virtues of a textbook and reference work to introduce and analyze these vital documents. Beginning with the foundational theory of human health risk assessment, it then supplies case studies and detailed analysis illustrating the practice of producing risk assessment documents. Fully updated and authored by leading authorities in the field, the result is an indispensable work. Readers of the second edition of Human and Ecological Risk Assessment will also find: Over 40 entirely new case studies reflecting the latest in risk assessment practice Detailed discussion of hazards including air emissions, contaminated food and soil, hazardous waste sites, and many more Case studies from multiple countries to reflect diverse international standards Human and Ecological Risk Assessment is ideal for professionals and advanced graduate students in toxicology, industrial hygiene, occupational medicine, environmental science, and all related subjects.
Author | : Kristine L. Willett |
Publisher | : CRC Press |
Total Pages | : 1118 |
Release | : 2024-02-06 |
Genre | : Science |
ISBN | : 1003825265 |
This up-to-date, comprehensive toxicology handbook is devoted to the effects of environmental pollution on fish. Fish species represent nearly half of all vertebrates and have become important sentinels for environmental contamination and model organisms for understanding adverse outcomes from exposures. This new edition is written by recognized experts, and it highlights the significant research progress in fish toxicology that has resulted from rapid technological developments in analytical, biochemical, and genomic sciences. The book: Discusses fundamental topics such as toxicokinetics in fishes, processes governing biotransformation within these organisms, and reactive oxygen species and oxidative stress. Explains key target organ systems for chemical impacts in fish, such as the nervous and immune systems, and how fishes can develop resistance to chemical toxicity. Covers multi-transgenerational effects on fishes, epigenetics, proteomics and metabolomics, and adverse outcome pathways. Replacing the case studies in the first edition, this update delves into the impacts of microplastics, pharmaceuticals, and oil spills in dedicated final chapters. With nearly 200 illustrations and tables, this comprehensive reference work presents concepts in a way that is useful for both novices to and experts in the field of fish toxicology.
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 154 |
Release | : 2014-09-03 |
Genre | : |
ISBN | : 9264085440 |
This document presents principles and helpful guides for validating (Q)SAR technology for a variety of applications.
Author | : Organisation for Economic Co-operation and Development |
Publisher | : Organisation for Economic Co-operation and Development ; [Montréal : Renouf] |
Total Pages | : |
Release | : 1981 |
Genre | : Chemical industry |
ISBN | : 9789264122215 |
Author | : Cornelis A. M. van Gestel |
Publisher | : CRC Press |
Total Pages | : 312 |
Release | : 2016-04-19 |
Genre | : Medical |
ISBN | : 1439830096 |
In the last decade and a half, great progress has been made in the development of concepts and models for mixture toxicity, both in human and environmental toxicology. However, due to their different protection goals, developments have often progressed in parallel but with little integration. Arguably the first book to clearly link ecotoxicology an
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 26 |
Release | : 2007-10-15 |
Genre | : |
ISBN | : 9264067396 |
A developmental neurotoxicity study will provide information on the effects of repeated exposure to a substance during in utero and early postnatal development. The test substance is administered daily, generally orally, to mated females (rats are ...
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 19 |
Release | : 2017-04-13 |
Genre | : |
ISBN | : 9264274758 |
Acute toxicity tests are an area of focus for developing alternative assays and approaches to address animal welfare concerns. In the context of this document, acute toxicity studies refer to studies involving a single exposure to a test chemical and include those assessing systemic toxicity as ...