Local circumstances affect individual well-being, the cohesiveness of societies and opportunities for a better future. With the How's Life in Your Region project, a part of the Better Life Initiative, the OECD launched in 2014 an innovative approach to measuring the quality of life at regional and local levels and understanding what needs to be done to achieve greater progress for all. Well-being indicators are a powerful instrument for helping governments identify where improvements are needed, prioritise areas for public intervention, and, ultimately, build trust in the ability of governments to bring change and improve people's lives. Mexico is the first country to have used the OECD Regional Well-Being Framework to develop objective and subjective indicators for twelve dimensions covering materialconditions and quality of life for the 31 Mexican states and the Federal District. This report provides evidence on well-being trends and drivers, disparities across states, and specific snapshots for each Mexican state. It uses the twelve well-being dimensions and 35 indicators chosen by the National Institute of Statistics and Geography of Mexico(INEGI) in consultation with state representatives and other federal agencies. The report offers a useful basis for better understanding local assets and constraints for regional development in Mexico. It also discusses how this data can help shape the policy debate and reformulate local and national policies.