OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 477: Genetic Toxicology: Sex-Linked Recessive Lethal Test in Drosophila melanogaster

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 477: Genetic Toxicology: Sex-Linked Recessive Lethal Test in Drosophila melanogaster
Author: OECD
Publisher: OECD Publishing
Total Pages: 6
Release: 1984-04-04
Genre:
ISBN: 9264071342

Mutations in the X-chromosome of Drosophila melanogaster are phenotypically expressed in males carrying the mutant gene. When the mutation is lethal in the hemizygous condition, its presence is inferred from the absence of one class of male ...

Test No. 478: Genetic Toxicology: Rodent Dominant Lethal Test

Test No. 478: Genetic Toxicology: Rodent Dominant Lethal Test
Author: OECD
Publisher: OECD Publishing
Total Pages: 6
Release: 1984-04-04
Genre:
ISBN: 9264071369

Dominant lethal (DL) effects cause embryonic or foetal death. Induction of a dominant lethal event after exposure to a test substance (liquid, solid, vapour or gas, ...) indicates that the substance has affected germinal tissue of the test species ...

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 479: Genetic Toxicology: In vitro Sister Chromatid Exchange Assay in Mammalian Cells

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 479: Genetic Toxicology: In vitro Sister Chromatid Exchange Assay in Mammalian Cells
Author: OECD
Publisher: OECD Publishing
Total Pages: 5
Release: 1986-10-23
Genre:
ISBN: 9264071385

The sister chromatid exchange (SCE) assay is a short-term test for the detection of reciprocal exchanges of DNA between two sister chromatids of a duplicating chromosome. Detection of SCEs requires some means of differentially labeling sister ...