Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 474 Mammalian Erythrocyte Micronucleus Test
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Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 21 |
Release | : 2014-09-26 |
Genre | : |
ISBN | : 9264224297 |
The mammalian in vivo micronucleus test detects damage induced by the test substance to the chromosomes or the mitotic apparatus of erythroblasts, by analysis of erythrocytes as sampled in bone marrow and/or peripheral blood cells of animals.
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 11 |
Release | : 1997-07-21 |
Genre | : |
ISBN | : 9264071288 |
The mammalian in vivo micronucleus test is used for the detection of damage induced by the test substance to the chromosomes or the mitotic apparatus of erythroblasts, by analysis of erythrocytes as sampled in bone marrow and/or peripheral blood ...
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 30 |
Release | : 2023-07-04 |
Genre | : |
ISBN | : 9264264868 |
The in vitro micronucleus test is a genotoxicity test for the detection of micronuclei in the cytoplasm of interphase cells.
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 37 |
Release | : 2022-06-30 |
Genre | : |
ISBN | : 9264366067 |
This Test Guideline describes an in vivo erythrocyte Pig-a gene mutation assay (hereafter called the Pig-a assay) which uses an endogenous mammalian gene, the phosphatidylinositol glycan class A gene (Pig-a), as a reporter of somatic-cell gene mutation. In vivo gene mutation tests, such as the Pig-a assay, are especially relevant for assessing mutagenicity because physiological factors, such as absorption of the test chemical from the site of exposure, distribution of the test chemical throughout the test system via systemic circulation, and in vivo metabolism and DNA repair processes, all contribute to the mutagenic responses.
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 18 |
Release | : 2016-07-29 |
Genre | : |
ISBN | : 9264264787 |
The mammalian in vivo chromosome aberration test is used for the detection of structural chromosome aberrations induced by test compounds in bone marrow cells of animals, usually rodents (rats, mice and Chinese hamsters).
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 21 |
Release | : 2016-07-29 |
Genre | : |
ISBN | : 9264264760 |
The mammalian in vivo micronucleus test is used for the detection of damage induced by the test substance to the chromosomes or the mitotic apparatus of erythroblasts, by analysis of erythrocytes as sampled in bone marrow and/or peripheral blood cells of animals, usually rodents (mice or rats).
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 22 |
Release | : 2016-07-29 |
Genre | : |
ISBN | : 9264264647 |
This test identifies agents that cause structural chromosome aberrations in cultured mammalian somatic cells.
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 23 |
Release | : 2010-07-23 |
Genre | : |
ISBN | : 9264091017 |
The in vitro micronucleus test is a genotoxicity test for the detection of micronuclei in the cytoplasm of interphase cells. Micronuclei may originate from acentric chromosome fragments (i.e. lacking a centromere), or whole chromosomes that are ...
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 24 |
Release | : 2016-07-29 |
Genre | : |
ISBN | : 9264264906 |
This TG includes two distinct in vitro mammalian gene mutation assays requiring two specific tk heterozygous cells lines: L5178Y tk+/-3.7.2C cells for the mouse lymphoma assay (MLA) and TK6 tk+/- cells for the TK6 assay.
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 18 |
Release | : 2016-07-29 |
Genre | : |
ISBN | : 9264264809 |
The in vitro mammalian cell gene mutation test can be used to detect gene mutations induced by chemical substances. In this test, the used genetic endpoints measure mutation at hypoxanthine-guanine phosphoribosyl transferase (HPRT), and at a transgene of xanthineguanine phosphoribosyl transferase...