Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 473 In Vitro Mammalian Chromosomal Aberration Test
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Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 22 |
Release | : 2016-07-29 |
Genre | : |
ISBN | : 9264264647 |
This test identifies agents that cause structural chromosome aberrations in cultured mammalian somatic cells.
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 20 |
Release | : 2014-09-26 |
Genre | : |
ISBN | : 926422422X |
This test identifies agents that cause structural chromosome aberrations in cultured mammalian somatic cells.
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 10 |
Release | : 1997-07-21 |
Genre | : |
ISBN | : 9264071261 |
The purpose of the in vitro chromosome aberration test is to identify agents that cause structural chromosome aberrations in cultured mammalian somatic cells. Structural aberrations may be of two types: chromosome or chromatid. The in vitro ...
Author | : Organisation for Economic Co-operation and Development |
Publisher | : |
Total Pages | : 20 |
Release | : 2014 |
Genre | : |
ISBN | : |
The purpose of the in vitro chromosome aberration test is to identify agents that cause structural chromosome aberrations in cultured mammalian somatic cells. Structural aberrations may be of two types: chromosome or chromatid. The in vitro chromosome aberration test may employ cultures of established cell lines, cell strains or primary cell cultures. Cell cultures are exposed to the test substance (liquid or solid) both with and without metabolic activation during about 1.5 normal cell cycle lengths. At least three analysable concentrations of the test substance should be used. At each concentration duplicate cultures should normally be used. At predetermined intervals after exposure of cell cultures to the test substance, the cells are treated with a metaphase-arresting substance, harvested, stained. Metaphase cells are analysed microscopically for the presence of chromosome aberrations.
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 18 |
Release | : 2016-07-29 |
Genre | : |
ISBN | : 9264264787 |
The mammalian in vivo chromosome aberration test is used for the detection of structural chromosome aberrations induced by test compounds in bone marrow cells of animals, usually rodents (rats, mice and Chinese hamsters).
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 13 |
Release | : 2015-07-28 |
Genre | : |
ISBN | : 9264243178 |
This test measures structural chromosomal aberrations (both chromosome- and chromatid-type) in dividing spermatogonial germ cells and is, therefore, expected to be predictive of induction of heritable mutations in these germ cells
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 18 |
Release | : 2015-07-28 |
Genre | : |
ISBN | : 9264243089 |
The in vitro mammalian cell gene mutation test can be used to detect gene mutations induced by chemical substances. In this test, the used genetic endpoints measure mutation at hypoxanthine-guanine phosphoribosyl transferase (HPRT), and at a transgene of xanthineguanine phosphoribosyl ...
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 21 |
Release | : 2016-07-29 |
Genre | : |
ISBN | : 9264264760 |
The mammalian in vivo micronucleus test is used for the detection of damage induced by the test substance to the chromosomes or the mitotic apparatus of erythroblasts, by analysis of erythrocytes as sampled in bone marrow and/or peripheral blood cells of animals, usually rodents (mice or rats).
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 5 |
Release | : 1986-10-23 |
Genre | : |
ISBN | : 9264071385 |
The sister chromatid exchange (SCE) assay is a short-term test for the detection of reciprocal exchanges of DNA between two sister chromatids of a duplicating chromosome. Detection of SCEs requires some means of differentially labeling sister ...
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 24 |
Release | : 2016-07-29 |
Genre | : |
ISBN | : 9264264906 |
This TG includes two distinct in vitro mammalian gene mutation assays requiring two specific tk heterozygous cells lines: L5178Y tk+/-3.7.2C cells for the mouse lymphoma assay (MLA) and TK6 tk+/- cells for the TK6 assay.