Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 442e In Vitro Skin Sensitisation In Vitro Skin Sensitisation Assays Addressing The Key Event On Activation Of Dendritic Cells On The Adverse Outcome Pathway For Skin Sensitisation
Download Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 442e In Vitro Skin Sensitisation In Vitro Skin Sensitisation Assays Addressing The Key Event On Activation Of Dendritic Cells On The Adverse Outcome Pathway For Skin Sensitisation full books in PDF, epub, and Kindle. Read online free Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 442e In Vitro Skin Sensitisation In Vitro Skin Sensitisation Assays Addressing The Key Event On Activation Of Dendritic Cells On The Adverse Outcome Pathway For Skin Sensitisation ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
| Author | : OECD |
| Publisher | : OECD Publishing |
| Total Pages | : 91 |
| Release | : 2024-06-25 |
| Genre | : |
| ISBN | : 9264264353 |
The present Key Event based Test Guideline (TG) addresses the human health hazard endpoint skin sensitisation, following exposure to a test chemical. Skin sensitisation refers to an allergic response following skin contact with the tested chemical, as defined by the United Nations Globally Harmonized System of Classification and Labelling of Chemicals (UN GHS). This TG is proposed to address the activation of dendritic cells, which is one Key Event on the Adverse Outcome Pathway (AOP) for Skin Sensitisation. It provides four in vitro test methods addressing the same Key Event on the AOP: (i) the human cell Line Activation Test or h-CLAT method, (ii) the U937 Cell Line Activation Test or U-SENS, (iii) the Interleukin-8 Reporter Gene Assay or IL-8 Luc assay and (iv) the Genomic Allergen Rapid Detection for assessment of skin sensitisers (GARDTMskin). All of them are used for supporting the discrimination between skin sensitisers and non-sensitisers in accordance with the UN GHS. The test methods described in this TG either quantify the change in the expression of cell surface marker(s) CD54 and CD86, the cytokine IL-8, or a series of genes (genomic biomarker signature) that are associated with the process of activation of monocytes and DC following exposure to sensitisers.
| Author | : Susan Nedorost |
| Publisher | : Elsevier Health Sciences |
| Total Pages | : 201 |
| Release | : 2021-07-08 |
| Genre | : Medical |
| ISBN | : 0323813461 |
Skin Allergy, An Issue of Immunology and Allergy Clinics of North America, E-Book
| Author | : Amy J. Clippinger |
| Publisher | : Frontiers Media SA |
| Total Pages | : 139 |
| Release | : 2022-12-16 |
| Genre | : Science |
| ISBN | : 2832508596 |
| Author | : Monika Schäfer-Korting |
| Publisher | : Springer Nature |
| Total Pages | : 325 |
| Release | : 2021-03-25 |
| Genre | : Medical |
| ISBN | : 3030700631 |
This book provides latest findings in organotypic models in drug development and provides the scientific resonance needed in an emerging field of research in disciplines, such as molecular medicine, physiology, and pathophysiology. Today the research on human-based test systems has gained major interest and funding in the EU and the US has increased over the last years. Moreover, so-called 3R (reduce, replace, refine animal experiments) centres have been established worldwide.
| Author | : Mariana Agostini De Moraes |
| Publisher | : Elsevier |
| Total Pages | : 658 |
| Release | : 2020-06-19 |
| Genre | : Technology & Engineering |
| ISBN | : 0128181354 |
Biopolymer Membranes and Films: Health, Food, Environment, and Energy Applications presents the latest techniques for the design and preparation of biopolymer-based membranes and films, leading to a range of cutting-edge applications. The first part of the book introduces the fundamentals of biopolymers, two-dimensional systems, and the characterization of biopolymer membranes and films, considering physicochemical, mechanical and barrier properties. Subsequent sections are organized by application area, with each chapter explaining how biopolymer-based membranes or films can be developed for specific innovative uses across the health, food, environmental and energy sectors. This book is a valuable resource for researchers, scientists and advanced students involved in biopolymer science, polymer membranes and films, polymer chemistry and materials science, as well as for those in industry and academia who are looking to develop materials for advanced applications in the health, food science, environment or energy industries. - Presents detailed coverage of a range of novel applications in key strategic areas across health, food, environment and energy - Considers the difficulties associated with two-dimensional materials - Assists the reader in selecting the best materials and properties for specific applications - Helps researchers, scientists and engineers combine the enhanced properties of membranes and films with the sustainable characteristics of biopolymer-based materials
| Author | : Frank Dreher |
| Publisher | : CRC Press |
| Total Pages | : 997 |
| Release | : 2022-08-11 |
| Genre | : Medical |
| ISBN | : 1000590623 |
With chapters from experienced and internationally renowned contributors holding positions in research, industry, and clinical practice, this is the fifth edition of what has become the standard reference for cosmetic scientists and dermatologists seeking the latest innovations and technology for the formulation, design, testing, use, and production of cosmetic products for the skin. *Offers in-depth analysis of specific topics in cosmetic science and research *Presents the latest in international research and its translation to practice *Gives an indispensable guide to a hotly competitive area for research and practice
| Author | : OECD |
| Publisher | : OECD Publishing |
| Total Pages | : 206 |
| Release | : 2018-12-10 |
| Genre | : |
| ISBN | : 9264304797 |
In the past several decades, there has been a substantial increase in the availability of in vitro test methods for evaluating chemical safety in an international regulatory context. To foster confidence in in vitro alternatives to animal testing, the test methods and conditions under which ...
| Author | : OECD |
| Publisher | : OECD Publishing |
| Total Pages | : 63 |
| Release | : 2015-02-05 |
| Genre | : |
| ISBN | : 9264229701 |
This Test Guideline addresses the human health hazard endpoint skin sensitisation, following exposure to a test chemical. It provides an in chemico procedure (Direct Peptide Reactivity Assay – DPRA) used for supporting the discrimination between skin sensitisers and non-sensitisers.
| Author | : OECD |
| Publisher | : OECD Publishing |
| Total Pages | : 53 |
| Release | : 2023-07-04 |
| Genre | : |
| ISBN | : 9264903003 |
A Defined Approach (DA) consists of a selection of information sources (e.g in silico predictions, in chemico, in vitro data) used in a specific combination, and resulting data are interpreted using a fixed data interpretation procedure (DIP) (e.g. a mathematical, rule-based model). DAs use methods in combination and are intended to overcome some limitations of the individual, stand-alone methods.
| Author | : Gianni Dal Negro |
| Publisher | : Academic Press |
| Total Pages | : 348 |
| Release | : 2021-11-18 |
| Genre | : Science |
| ISBN | : 0128212527 |
Practical Handbook on the 3Rs in the Context of the Directive 2010/63/EU provides updated information on the EU Directive 2010/63/EU, which is the European Union legislation that protects animals being used in research. EU Directive 2010/63/EU is the European Union (EU) legislation 'on the protection of animals used for scientific purposes' and is one of the most stringent ethical and welfare standards worldwide. - Closes a gap in scientific literature by addressing the need for clear guidance in walking through the multifaced universe of 3Rs - Offers a useful starting point for readers and scientist who approach the 3Rs for the first-time - Gives insights into the harmonization of the animal research legislation across countries
