Novel Cytokine Inhibitors
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| Author | : Gerry A. Higgs |
| Publisher | : Springer |
| Total Pages | : 284 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 3034884508 |
Cytokines have become established as key mediators of the signs and symptoms of inflammatory diseases such as arthritis, dermatitis, asthma and multiple sclerosis. Furthermore, they are involved in the cascade of events leading to cardiovascular shock and are major regulators of the function of immune cells. This book reviews recent advances in the development of new anti-inflammatory drugs. It addresses different therapeutic intervention possibilities for new drugs, such as the cellular source of cytokines, specific receptors which induce cytokine synthesis, intracellular regulators of cytokine gene induction and expression, secretion and activation of cytokines, cytokine receptors and signalling pathways from these receptors. Accordingly, experts were drawn from different backgrounds including academic research institutes, the pharmaceutical industry and clinical pharmacology. In each area, the opportunities for drug development are highlighted and, where possible, clinical data is reviewed.
| Author | : Randy Q. Cron |
| Publisher | : Springer Nature |
| Total Pages | : 609 |
| Release | : |
| Genre | : |
| ISBN | : 3031598156 |
| Author | : Michael J. Parnham |
| Publisher | : Springer Nature |
| Total Pages | : 888 |
| Release | : 2019-12-10 |
| Genre | : Medical |
| ISBN | : 3030108112 |
Principles of Immunopharmacology provides a unique source of essential knowledge on the immune response, its diagnosis and its modification by drugs and chemicals. The 4th edition of this internationally recognized textbook has been revised to include recent developments, but continues the established format, dealing with four related fields in a single volume, thus obviating the need to refer to several different textbooks. The first section of the book, providing a basic introduction to immunology and its relevance for human disease, has been updated to accommodate new immunological concepts, particularly the role of epigenetics and the latest understanding of cancer immunology. The second section on immunodiagnostics offers a topical description of widely used molecular techniques and a new chapter on imaging techniques. This is followed by a systematic coverage of drugs affecting the immune system, including natural products. This third section contains 15 updated chapters, covering classical immunopharmacological topics such as anti-asthmatic, anti-rheumatic and immunosuppressive drugs, but also deals with antibiotics, plant-derived and dietary agents, with new chapters on monoclonal antibodies, immunotherapy in sepsis and infection, drugs for soft-tissue autoimmunity and cell therapy. The book concludes with a chapter on immunotoxicology and drug safety tests. Aids to the reader include a two-column format, glossaries of technical terms and appendix reference tables. The emphasis on illustrations is maintained from the first three editions. The book is a valuable single reference for undergraduate and graduate medical and biomedical students, postgraduate chemistry and pharmacy students, researchers in chemistry, biochemistry and the pharmaceutical industry and researchers lacking basic immunological knowledge, who want to understand the actions of drugs on the immune system.
| Author | : Z. Kmiec |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 154 |
| Release | : 2013-06-29 |
| Genre | : Science |
| ISBN | : 3642565530 |
It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better understood. The development of methods for isolation and co-culturing various types of liver cells has established that they communicate and cooperate via secretion of various intercellular mediators. This monograph summarizes multiple data that suggest the important role of cellular cross-talk for the functions of both normal and diseased liver. Special features of the book include concise presentation of the majority of detailed data in 19 tables. Original schemes allow for the clear illustration of complicated intercellular relationships. This is the first ever presentation of the newly emerging field of liver biology, which is important for hepatic function in health and disease and opens new avenues for therapeutic interventions.
| Author | : P. Miossec |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 256 |
| Release | : 1998-07-21 |
| Genre | : Medical |
| ISBN | : 9783764358532 |
Rheumatoid arthritis (RA) is the most common and most severe form of inflammatory arthritis. The pathogenesis of RA has been the subject of intense research for several decades. The prevailing hypotheses have changed over the years, and have attempted to incorporate the most recent data. Although T cells represent an important component of the cells which infiltrate the joint synovium, their contribution at a late stage of the disease remains a matter of debate. The goal of this book is to outline the major arguments and data suggesting that T cells may, or may not, be central players in the pathogenesis of chronic RA. While each of the editors and authors has his/her own bias (as will be clear by reading the respective chapters), our hope is that the readers will enjoy a complete and balanced view of the critical questions and experiments. This is not just an intellectual exercise since the direction of future therapeutic interventions depends heavily on how one interprets the pathogenesis of RA and the contribution of T cells.
| Author | : E. Carstens |
| Publisher | : CRC Press |
| Total Pages | : 482 |
| Release | : 2014-02-25 |
| Genre | : Science |
| ISBN | : 1466505435 |
Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain. Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer. Composed of contributions from distinguished researchers around the world, the book explores topics such as: Neuropathic itch Peripheral neuronal mechanism of itch The role of PAR-2 in neuroimmune communication and itch Mrgprs as itch receptors The role of interleukin-31 and oncostatin M in itch and neuroimmune communication Spinal coding of itch and pain Spinal microcircuits and the regulation of itch Examining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.
| Author | : Roger W. Byard |
| Publisher | : |
| Total Pages | : 844 |
| Release | : 2018-04 |
| Genre | : Medical |
| ISBN | : 9781925261677 |
This volume covers aspects of sudden infant and early childhood death, ranging from issues with parental grief, to the most recent theories of brainstem neurotransmitters. It also deals with the changes that have occurred over time with the definitions of SIDS (sudden infant death syndrome), SUDI (sudden unexpected death in infancy) and SUDIC (sudden unexpected death in childhood). The text will be indispensable for SIDS researchers, SIDS organisations, paediatric pathologists, forensic pathologists, paediatricians and families, in addition to residents in training programs that involve paediatrics. It will also be of use to other physicians, lawyers and law enforcement officials who deal with these cases, and should be a useful addition to all medical examiner/forensic, paediatric and pathology departments, hospital and university libraries on a global scale. Given the marked changes that have occurred in the epidemiology and understanding of SIDS and sudden death in the very young over the past decade, a text such as this is very timely and is also urgently needed.
| Author | : |
| Publisher | : Elsevier |
| Total Pages | : 609 |
| Release | : 2008-06-18 |
| Genre | : Science |
| ISBN | : 0080559352 |
This book opens a new page of neuro-immunobiology providing substantive experimental and clinical data to support current understanding in the field, and potential applications of this knowledge in the treatment of disease. The volume is a collection of complex, new data drawn from multiple areas of investigation in the field. The contents summarize current understanding on the presence and function of CNS cytokines and their receptors in a variety of CNS cells during health and disease. The chapters are a collection of complex, new data demonstrating the presence and synthesis of cytokines in brain cells, as well as their receptors on cell membranes in health and disease. The strength of the volume are the descriptions of the authors own investigations, together with those of others in the field pertaining to a large number of cytokines in brain function, as well as mechanisms involved in the development of CNS disorders, including multiple sclerosis and Alzheimer's disease. Also included are novel approaches to the treatment of CNS disorders based on new experimental data. The contributors to this volume are internationally known scientists and clinical researchers in their respective fields of investigation and treatment.*Opens a new page of neuro-immunobiology and provides substantive evidence for the promise of this field in the treatment of disease*Summarizes current understanding on the presence and function of central nervous system (CNS) cytokines and their receptors in a variety of CNS cells during health and disease*Includes novel approaches to the treatment of CNS disorders based on new experimental data*Offers new insight into triggers for the development of autoimmune diseases in the brain and the possibilities for treatment
| Author | : Alberto Mantovani |
| Publisher | : Oxford University Press, USA |
| Total Pages | : 354 |
| Release | : 2000 |
| Genre | : Medical |
| ISBN | : |
Cytokines are the "words" of immunity, serving as mediators within and outside the immune system. There is tremendous interest in their expliotation as therapeutic tools in diverse human diseases and considerable effort has been made to understand and utilize their pharmacology. This book examines this pharmacology, from developments and characterization of simple chemicals and their mechanism of action to the use of biotechnology-based approaches. The book puts cytokines and their pharmacology in context and examines their involvement in individual organ-disease systems.
| Author | : L.R. Watkins |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 248 |
| Release | : 1999 |
| Genre | : Medical |
| ISBN | : 9783764358495 |
The purpose of this book is to examine immune-to-brain communication from the viewpoint of its effect on pain processing, and to clarify the major role that substances released by immune cells play in pain modulation. In these chapters, contributed by major laboratories whose focus is understanding how cytokines modulate pain, the perspectives examined range from evolutionary approaches across diverse species, to the basics of the immune response, to the effect of cytokines on peripheral and central nervous system sites, to therapeutic potential in humans. -- book cover.
