Notch Signaling In Embryology And Cancer
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| Author | : Jörg Reichrath |
| Publisher | : Springer Nature |
| Total Pages | : 200 |
| Release | : 2020-02-14 |
| Genre | : Medical |
| ISBN | : 3030344363 |
This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer. It discusses this topic from Notch’s role in the development of the embryo to the Notch signaling pathway’s role in the development of a number of cancers, including breast cancer, malignant melanoma, Non-melanoma skin cancer, intestinal cancer and others. In the years since the previous edition, there have been numerous developments and insights within this rapidly moving field, making this new edition urgently needed. This volume also features discussions of current insights on Notch’s role in senescence, the regulation of Notch signaling by microRNAs, Notch’s role in the microbiome, diet and its influence on Notch signaling and more. Taken as a whole, with its companion books – Molecular Biology of Notch Signaling and Notch Signaling in Cancer – this is a definitive discussion of the topic, presented by internationally-recognized contributors. Presented in a coherent and accessible structure, this revised and updated second edition is an essential and up-to-date guide for oncologists, embryologists, researchers and advanced students.
| Author | : Jörg Reichrath |
| Publisher | : Springer Nature |
| Total Pages | : 228 |
| Release | : 2020-10-08 |
| Genre | : Medical |
| ISBN | : 3030550311 |
This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer. It discusses this topic from Notch’s role in the development of the embryo to the Notch signaling pathway’s role in the development of a number of cancers, including breast cancer, malignant melanoma, Non-melanoma skin cancer, intestinal cancer and others. In the years since the previous edition, there have been numerous developments and insights within this rapidly moving field, making this new edition urgently needed. This volume also features discussions of current insights on Notch’s role in senescence, the regulation of Notch signaling by microRNAs, Notch’s role in the microbiome, diet and its influence on Notch signaling and more. Taken as a whole, with its companion books -- Notch Signaling and Embryologic Development and Molecular Basis of Notch Signaling – this is a definitive discussion of the topic, presented by internationally-recognized contributors. Presented in a coherent and accessible structure, this revised and updated second edition is an essential and up-to-date guide for oncologists, embryologists, researchers and advanced students.
| Author | : Jörg Reichrath |
| Publisher | : Springer Nature |
| Total Pages | : 179 |
| Release | : 2020-02-18 |
| Genre | : Medical |
| ISBN | : 3030364224 |
This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer. It summarizes the newest achievements on this topic from Notch’s flag-ship function in the development of the embryo and for various inherited diseases to the Notch signaling pathway’s role in the development of leukemia and in a number of cancers, including skin cancer, intestinal cancer and others. Additionally, the emerging new role of the Notch signaling pathway as a promising target for prevention and therapy of various diseases, including cancer, is discussed. In the years since the previous edition, there have been numerous developments and insights within this rapidly moving field, making this new edition urgently needed. This volume also features discussions of current insights on Notch’s role for embryologic tissue patterning, for stem cells, in senescence, and on the regulation of Notch signaling by epigenetic and other factors including microRNAs, long non-codingRNAs, and more. Taken as a whole, with its companion books – Notch Signaling in Embryology and Notch Signaling in Cancer – this is a definitive discussion of the topic, presented by internationally-recognized contributors. Presented in a coherent and accessible structure, this revised and updated second edition is an essential and up-to-date guide for oncologists, embryologists, researchers and advanced students.
| Author | : Jörg Reichrath |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 346 |
| Release | : 2012-03-07 |
| Genre | : Medical |
| ISBN | : 1461408997 |
The goal of this volume is to comprehensively cover a highly readable overview on our present knowledge of the role of Notch signalling for embryology and cancer, with a focus on new findings in molecular biology. Topics that are discussed in-depth by leading researchers and clinicians range from the newest findings in cellular and molecular pathology to new concepts for prophylaxis and treatment of cancer. Experts in the field as well as scientists and health care professionals not intimately involved in these specialized areas are provided with the most significant and timely information related to these topics. It is the aim of this book to summarize essential up-to-date information for every clinician or scientist interested in the role of Notch signalling in embryology and cancer. We hope that this volume will be adopted as the standard text in this area of science and will stimulate new interest in the role of Notch signalling for embryology and cancer. We further hope that this compendium will serve as both a source for current researchers and a guide to stimulate and assist those in related disciplines to enter this exciting field of research.
| Author | : |
| Publisher | : |
| Total Pages | : 179 |
| Release | : 2020 |
| Genre | : Cellular signal transduction |
| ISBN | : 9783030364236 |
This comprehensive assessment of our present knowledge of the role of notch signaling in embryology and cancer analyzes a range of topics from the latest findings in cellular and molecular pathology to new concepts for prophylaxis and treatment of cancer.
| Author | : |
| Publisher | : |
| Total Pages | : 200 |
| Release | : 2020 |
| Genre | : Cellular signal transduction |
| ISBN | : 9783030344375 |
This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer. It discusses this topic from Notch's role in the development of the embryo to the Notch signaling pathway's role in the development of a number of cancers, including breast cancer, malignant melanoma, Non-melanoma skin cancer, intestinal cancer and others. In the years since the previous edition, there have been numerous developments and insights within this rapidly moving field, making this new edition urgently needed. This volume also features discussions of current insights on Notch's role in senescence, the regulation of Notch signaling by microRNAs, Notch's role in the microbiome, diet and its influence on Notch signaling and more. Taken as a whole, with its companion books - Molecular Biology of Notch Signaling and Notch Signaling in Cancer - this is a definitive discussion of the topic, presented by internationally-recognized contributors. Presented in a coherent and accessible structure, this revised and updated second edition is an essential and up-to-date guide for oncologists, embryologists, researchers and advanced students. --
| Author | : Juan J. Sanz-Ezquerro |
| Publisher | : Frontiers Media SA |
| Total Pages | : 179 |
| Release | : 2017-11-30 |
| Genre | : |
| ISBN | : 2889453464 |
The formation of a complex multicellular organism from a single cell is one of the most amazing processes of biology. Embryonic development is characterised by the careful regulation of cellular behaviours such that cells proliferate, migrate, differentiate and form tissues at the correct place and time. These processes are genetically controlled and depend both on the history of cells, their lineage, and on the activities of signalling pathways, which coordinate the cell interactions leading to organogenesis. The aim of the Frontiers research topic “Signalling pathways in embryonic development” has been to provide a forum for experts in cell and developmental biology to share recent advances in the field of signalling during embryonic development. Sixteen articles in a variety of formats are united in this Topic, offering a valuable collection for researchers looking for an update in the knowledge of signalling pathways operating during embryogenesis. The works, focused mainly on vertebrates, explore different aspects of this theme from cell communication to organ formation and have implications for areas as distant as evolution or pathology. Understanding developmental signalling pathways is important for several reasons. It gives us information about basic mechanisms of cell function and interactions needed for morphogenesis and organogenesis. It uncovers the basis of congenital malformations, since errors at any step of cell signalling during development are a major cause of defects. This fundamental insight gives us clues to understand the mechanisms operating in evolution that explain diversity in form and function. And finally, it allows the identification of possible causes of disease in the adult organism (such as cancer or degenerative diseases) pinpointing possible targets for therapeutic approaches.
| Author | : Lucio Miele |
| Publisher | : Springer |
| Total Pages | : 389 |
| Release | : 2018-11-23 |
| Genre | : Medical |
| ISBN | : 149398859X |
The serendipitously discovered link between developmental biology and cancer, touched of an explosion of discoveries on the role of Notch in human malignancies, including every aspect of cancer biology, from control of differentiation, proliferation and apoptosis in transformed cells to angiogenesis, tumor-stroma interaction and anti-cancer immune responses. A number of observations have revealed that Notch even plays a role in the renewal of cancer stem cells and tumor initiating cells, which are thought to be a major cause of resistance to treatment. Targeting Notch in Cancer will provide researchers, oncologists, pharmacologists and students with a detailed understanding of the intricate cross-talk between Notch and other pathways of therapeutic interest so to better design rational drug combinations for specific diseases and disease subsets. Divided into two parts, Part I describes in detail what we know about the genetics, molecular biology, biochemistry and structural biology of Notch, as well as the role of Notch in such processes as angiogenesis and immune surveillance. Without insights gained from these basic studies, rational targeting of Notch in human disease would be impossible. Part II describes the role of Notch and ongoing experimental therapeutic efforts in the most important subtypes of human cancers, organized in a clinically oriented fashion by organs and systems affected
| Author | : Stephen Pandol |
| Publisher | : Morgan & Claypool Publishers |
| Total Pages | : 66 |
| Release | : 2011 |
| Genre | : Medical |
| ISBN | : 1615041389 |
The secretions of the exocrine pancreas provide for digestion of a meal into components that are then available for processing and absorption by the intestinal epithelium. Without the exocrine pancreas, malabsorption and malnutrition result. This chapter describes the cellular participants responsible for the secretion of digestive enzymes and fluid that in combination provide a pancreatic secretion that accomplishes the digestive functions of the gland. Key cellular participants, the acinar cell and the duct cell, are responsible for digestive enzyme and fluid secretion, respectively, of the exocrine pancreas. This chapter describes the neurohumoral pathways that mediate the pancreatic response to a meal as well as details of the cellular mechanisms that are necessary for the organ responses, including protein synthesis and transport and ion transports, and the regulation of these responses by intracellular signaling systems. Examples of pancreatic diseases resulting from dysfunction in cellular mechanisms provide emphasis of the importance of the normal physiologic mechanisms.
| Author | : |
| Publisher | : |
| Total Pages | : 10 |
| Release | : 2004 |
| Genre | : |
| ISBN | : |
Constitutively active forms of Notch receptors have been shown to have oncogenic potential in several cell-types. Aberrant expression of Notch signaling pathway components has been detected in several human tumors, including breast cancer. Since Ras signaling is also activated in several breast cancers, I propose to study the potential interactions between Notch and Ras signaling in breast carcinogenesis. Initial observations revealed that coexpression of a constitutively active form of Notch1 in immortalized breast epithelial HMLE cells expressing low levels of oncogenic Ras rendered them fully transformed. These cells generated soft agar colonies in vitro, and tumors when injected subcutaneously in nude mice. Further characterization of the Notch-Ras pathway interaction revealed that nuclear localization of Notch1 is essential for this cooperation. Dissection of Ras-pathways using the Ras-effector loop mutants revealed that compared to G37 and C40, that activate Ral-GEF and PI3K, respectively, the 535 mutant, which preferentially activates Raf/MAPK pathway, formed efficient colonies with activated Notch1. Interestingly, I found that expression of activated Notch1 rendered the HMLE-low Ras cells highly spindly and fibroblastic - characteristics of epithelial-to-mesenchyme transition (EMT) associated with tumor invasion and metastasis. Very recent reports have indeed demonstrated a role for Notch signaling in EMT associated with normal development and cancers. Accordingly, I investigated the role of Notch signaling in the EMT phenotype of breast cancer cells. I found that inhibition of Notch signaling, using presenilin inhibitor, caused the highly metastatic SUM1315 breast cancer cells to revert to an epithelial phenotype, thereby suggesting that Notch signaling may play an important role in mediating/maintaining the EMT phenotype of breast cancer cells.
