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Author | : I. Ferkolj |
Publisher | : Springer Science & Business Media |
Total Pages | : 289 |
Release | : 2011-04-28 |
Genre | : Medical |
ISBN | : 1402087675 |
The translation of new molecular understanding of disease into clinical practice in gastroenterology is a special challenge. The Falk Symposium No. 160, entitled ‘Pathogenesis and Clinical Practice in Gastroenterology’, held 15-16 June 2007 in Portorož, Slovenia, provided a stimulating framework to bridge discussions from bench to bedside. The proceedings of the symposium are contained in this book, and the unifying theme is the growing understanding of inflammation as a driving force in chronic disease leading to disability and malignancy. Aspects of early detection - endoscopically or via molecular markers - are covered as well as in-depth discussions of the validation of new findings in clinical practice. Whilst on a molecular basis gastroenterologists and hepatologists try to shed light on the same intracellular pathways, clinical implications such as surveillance of cancer in IBD or chronic hepatitis with cirrhosis have to be tailored to specific needs. New therapeutic agents - approved or on the horizon of early clinical studies - will dramatically change the options of patients with chronic disease such as Crohn’s disease, viral hepatitis or hepatocellular carcinoma.
Author | : Richard Blumberg |
Publisher | : Springer Science & Business Media |
Total Pages | : 262 |
Release | : 2007-02-26 |
Genre | : Medical |
ISBN | : 0387337784 |
Immune Mechanisms in Inflammatory Bowel Disease is a highly, concise update of the most recent advances in the immunobiology, genetics and microbiology related to Inflammatory Bowel Disease. This book broadly treats the topics that lead to understanding of the pathogenesis of this disease in an organized, systematic approach.
Author | : John A. Walker-Smith |
Publisher | : Karger Medical and Scientific Publishers |
Total Pages | : 213 |
Release | : 2009 |
Genre | : Medical |
ISBN | : 3805591349 |
Chronic inflammatory bowel disease (IBD) encompasses Crohn's disease, ulcerative colitis and indeterminate colitis. The distinct phenotype in pediatric and adolescent patients and the difference from adult IBD make early-onset IBD a unique subgroup requiring specific therapeutic considerations. In this book, leading experts from the USA, Europe and Israel present new data on the genetics, epidemiology, pathology and pathogenesis of pediatric IBD. Imaging and endoscopy in the diagnosis of IBD are also discussed. Extensive coverage is given to disease management, i.e. pharmacological, nutritional and surgical approaches, with special emphasis on growth failure and delayed puberty. The important topic of transition from pediatric to adult medical care is highlighted and a clinical and developmental timeline is proposed.Offering practical information on IBD in infants, toddlers, children, adolescents and young adults, this book is essential reading for gastroenterologists, in particular pediatric gastroenterologists and trainees, as well as general pediatricians and nutritionists.
Author | : Ellen J. Scherl |
Publisher | : SLACK Incorporated |
Total Pages | : 296 |
Release | : 2009 |
Genre | : Age factors in disease |
ISBN | : 9781556428418 |
Author | : Derek J. Chadwick |
Publisher | : John Wiley & Sons |
Total Pages | : 238 |
Release | : 2005-06-10 |
Genre | : Science |
ISBN | : 0470090472 |
Inflammatory bowel disease (IBD) comprises a group of idiopathic diseases of the intestine characterized by chronic inflammation of the bowel with periods of exacerbation and remission. Although the exact cause of IBD remains undetermined, the condition appears to be related to a combination of genetic and environmental factors resulting in an aberrant activation of the mucosal immune system. This book contains a series of interdisciplinary discussions between clinical and basic scientists focusing on key issues such as: Epithelial cell and molecular biology, including apoptosis, necrosis and cell survival The role of bacterial milieu and mucosal bacteria in the IBD and of prebiotic and probiotic therapy The progress towards the identification of susceptibility genes and phenotype-determining genes The pharmacogenetics of IBD Mucosal immunology and therapeutic strategies stemming therefrom
Author | : Russell D. Cohen |
Publisher | : Springer Science & Business Media |
Total Pages | : 328 |
Release | : 2011-03-22 |
Genre | : Medical |
ISBN | : 1603274332 |
As in the first edition of Inflammatory Bowel Diseases this new edition continues to provide readers with a concise, yet in-depth review of many of the important areas in the history, epidemiology, pathogenesis, diagnosis, and treatment of the inflammatory bowel diseases (ulcerative colitis and Crohn's disease), as well as associated issues: extraintestinal manifestations, ostomy care, women's issues, economics, etc. This Second Edition provides the reders with up-to-date, state-of-the art approaches to these disease states, with expansion into the newer topics that have emerged in the past few years which include the expansion of biological agents for treatment, new studies in the epidemiology of IBD, the changing economics of IBD, breakthroughs in new endoscopic evaluations, major advances in novel radiographic techniques, the detection of colorectal cancer in patients with IBD and new findings in the genetics of IBD. New Trend / Developments (* These all emerged since our last edition) The most critical trend that has arisen over the past few years has been the introduction and expansion of biological agents in the treatment of inflammatory diseases worldwide. While only one agent, infliximab (Remicade), existed at the time of publication of my first edition, there have been multiple other agents either approved or pending approval for the treatments of these diseases, or in the upper-stages of development. The impact is not only upon the patients, but also on the health-care providers, policy makers, researchers, biotech and pharmacompanies, and the business community. Major changes worldwide in the epidemiology of IBD has spurred new studies in the demographics of who is getting these diseases and why. Previously characterized as diseases primarily affected Caucasians in industrialized countries, there has been an explosion of growth amongst the African American and Hispanic populations in the United States, and well as in pockets of these and other ethnic groups worldwide. The economics of IBD has been changing greatly, given the issues raised above, as well as major changes in the United States Medicare program, and other insurance changes. The growing proportion of the GNP that healthcare costs are consuming in the US and worldwide has shifted attention to decreasing utilization of health care services, and other cost-savings measures. Again, up to this point this has been an exclusive part of our IBD book. New findings in the genetics of IBD have been recently published. Our first edition had the finding of the first Crohn’s disease gene inserted just before going to press; so much has been published about the phenotypes and other genotypes that have emerged. Breakthroughs in new endoscopic evaluations of the bowel (ie. Capsule endoscopy, double-balloon enteroscopy, endoscopic ultrasound) and their use in the inflammatory bowel diseases will be a key highlight of this new book. Major advances in novel radiographic techniques employed in patients with inflammatory bowel disease (ie. CT enterography, MR enterography, advanced ultrasounds, etc.) will also an important component of our work. There have been numerous areas related to the development and detection of colorectal cancer in patients with IBD that have emerged in the past few years. Techniques of better detection (ie. Narrow band imaging; special mucosal staining; endoscopic histological evaluations) as well as research in the putative role of mesalamine and other agents for colorectal cancer prevention are all hot topics that will attract much interest from a variety of interest groups I described above. Identification of additional disease states that probably belong in the IBD family, such as microscopic colitis (including lymphocytic colitis), and collagenous colitis add to the diseases that will be discussed in this new edition.
Author | : |
Publisher | : ScholarlyEditions |
Total Pages | : 161 |
Release | : 2012-01-09 |
Genre | : Medical |
ISBN | : 1464901678 |
Crohn's Disease: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Crohn's Disease. The editors have built Crohn's Disease: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Crohn's Disease in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Crohn's Disease: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author | : Mark Feldman |
Publisher | : Elsevier Health Sciences |
Total Pages | : 3112 |
Release | : 2020-06-09 |
Genre | : Medical |
ISBN | : 0323710948 |
For nearly 50 years, Sleisenger & Fordtran’s Gastrointestinal and Liver Disease has been the go-to reference for gastroenterology and hepatology residents, fellows, physicians, and the entire GI caregiving team. Now in a fully revised 11th Edition, this two-volume masterwork brings together the knowledge and expertise of hundreds of global experts who keep you up to date with the newest techniques, technologies, and treatments for every clinical challenge you face in gastroenterology and hepatology. A logical organization, more than 1,100 full-color illustrations, and easy-to-use algorithms ensure that you’ll quickly and easily find the information you need. Features new and expanded discussions of chronic hepatitis B and C, Helicobacter pylori infection, colorectal cancer prevention through screening and surveillance, biologic agents and novel small molecules to treat and prevent recurrences of inflammatory bowel disease (IBD), gastrointestinal immune and autoimmune diseases, and more. Offers reliable coverage of key topics such as Barrett’s esophagus, gut microbiome, enteric microbiota and probiotics, fecal microbiota transplantation, and hepatic, pancreatic, and small bowel transplantation. Provides more quick-reference algorithms that summarize clinical decision making and practical approaches to patient management. Employs a consistent, templated, format throughout for quick retrieval of information. Includes monthly updates online, as well as more than 20 procedural videos.
Author | : Derek P. Jewell |
Publisher | : John Wiley & Sons |
Total Pages | : 416 |
Release | : 2008-04-15 |
Genre | : Medical |
ISBN | : 1405171766 |
Reviews focused topics – both clinical and basic science - in the fast-moving area of IBD, providing emphasis on the current challenges faced in the successful management of the disease Turn to Challenges in Inflammatory Bowel Disease (IBD) when you need an expert opinion on the new, unusual or controversial areas of IBD and not just the tried and tested information. Current and concise reviews of the latest scientific discoveries are translated into cutting-edge clinical guidance to address those challenging cases faced by every medical team caring for patients with IBD. Refer to this book to answer burning questions, to read an in depth review of the controversial topics and to provide a clear explanation of issues.
Author | : Anke-Hilse Maitland-van der Zee |
Publisher | : John Wiley & Sons |
Total Pages | : 514 |
Release | : 2012-05-08 |
Genre | : Medical |
ISBN | : 047043354X |
This resource provides thorough coverage of pharmacogenetics and its impact on pharmaceuticals, therapeutics, and clinical practice. It opens with the basics of pharmacogenetics, including drug disposition and pharmacodynamics. The following section moves into specific disease areas, including cardiovascular, psychiatry, cancer, asthma/COPD, adverse drug reactions, transplantation, inflammatory bowel disease, and pain medication. Clinical practice and ethical issues make up the third section, with the fourth devoted to technologies like genotyping, genomics, and proteomics. In the fifth part, chapters discuss the impact of key regulatory issues on the pharmaceutical industry.