NLRP3 Inflammasome: Regulatory Mechanisms, Role in Health and Disease and Therapeutic Potential
| Author | : Kuo-Feng Hua |
| Publisher | : Frontiers Media SA |
| Total Pages | : 376 |
| Release | : 2021-11-08 |
| Genre | : Medical |
| ISBN | : 2889716023 |
Nlrp3 Inflammasome Regulatory Mechanisms Role In Health And Disease And Therapeutic Potential
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The Inflammasome
| Author | : Christine M. De Nardo |
| Publisher | : Humana |
| Total Pages | : 0 |
| Release | : 2013-07-13 |
| Genre | : Medical |
| ISBN | : 9781627035224 |
This Methods in Molecular Biology book offers methods for studying inflammasome function, including generation of inflammasome stimuli, monitoring of caspase-1 activity and processing, activation of IL-1β cytokines, plus lab protocols, material lists and tips.
Melatonin
| Author | : Andrew Miles |
| Publisher | : Oxford University Press, USA |
| Total Pages | : 312 |
| Release | : 1988 |
| Genre | : Medical |
| ISBN | : |
A review of the areas of clinical medicine where melatonin is thought to play an important role, attempting to clarify the role of melatonin, to suggest avenues for future research, and to provide the first synthesis of basic and clinical research for scientists and those in pineal research.
Free Fatty Acid Receptors
| Author | : Graeme Milligan |
| Publisher | : Springer |
| Total Pages | : 258 |
| Release | : 2017-02-08 |
| Genre | : Medical |
| ISBN | : 3319506935 |
This book highlights the important role free fatty acids (FFA) play as potential drug targets. While FFA have long been considered byproducts of cell metabolism, they are now recognized as ligands that regulate cell and tissue function via G-protein-coupled receptors. At least three receptors have been identified for which FFA appear to be the endogenous ligands.
Autophagy: Biology and Diseases
| Author | : Weidong Le |
| Publisher | : Springer Nature |
| Total Pages | : 734 |
| Release | : 2020-07-15 |
| Genre | : Medical |
| ISBN | : 9811542724 |
This book consists of 3 volumes: Basic Science (Volume 1), Clinical Science (Volume 2) and Technology and Methodology (Volume 3). Volume 2 focuses on the clinical aspects of autophagy research, discussing the role of autophagy in neuropsychiatric disorders, the cardiovascular, immune, digestive and endocrine systems, as well as tumors, infection, the kidney, and the respiratory and hematological systems. It also addresses autophagy-related drug development. Written and edited by a team of 90 experts, and presenting the state of the art in autophagy research, this book is a valuable reference resource for researchers and clinicians alike. It can also be used as supplementary material for graduate students majoring in biology and medicine
The Cytokines of the Immune System
| Author | : Zlatko Dembic |
| Publisher | : Academic Press |
| Total Pages | : 323 |
| Release | : 2015-05-23 |
| Genre | : Medical |
| ISBN | : 0124200109 |
The Cytokines of the Immune System catalogs cytokines and links them to physiology and pathology, providing a welcome and hugely timely tool for scientists in all related fields. In cataloguing cytokines, it lists their potential for therapeutic use, links them to disease treatments needing further research and development, and shows their utility for learning about the immune system. This book offers a new approach in the study of cytokines by combining detailed guidebook-style cytokine description, disease linking, and presentation of immunologic roles. - Supplies new ideas for basic and clinical research - Provides cytokine descriptions in a guidebook-style, cataloging the origins, structures, functions, receptors, disease-linkage, and therapeutic potentials - Offers a textbook-style view on the immune system with the immunologic role of each cytokine
Motor Neuron Disease in Adults
| Author | : Mark B. Bromberg |
| Publisher | : Contemporary Neurology |
| Total Pages | : 369 |
| Release | : 2014-10-28 |
| Genre | : Medical |
| ISBN | : 019978311X |
'Motor Neuron Disease in Adults' reviews new information from 1998 as it applies to all aspects of motor neuron disease. Articles included use evidence-based methods to ensure that the new information is solid and advances the topic. The book can be used by anyone who provides any type of care to ALS patients.
DNA Sensors and Inflammasomes
| Author | : |
| Publisher | : Academic Press |
| Total Pages | : 0 |
| Release | : 2019-08-29 |
| Genre | : Science |
| ISBN | : 9780128183595 |
DNA Sensors and Inflammasomes, Volume 625, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. New sections in this release include Phosphorylation and dimerization of STING and IRF3, cGAS enzymology, Synthesis and identification of immuno-stimulatory CDNs, Tracking cGAS activity/ cGAMP formation using SPR/NMR, Using an enzyme coupled assay to track cGAS activity under steady states, Tracking the polymerization of DNA sensors, inflammasome receptors, and downstream signaling partners using FRET, NLRC4 structure, Tracking TREX1 activity, DNA association and dissociation kinetics of PARP1, and more.
Biology of C Reactive Protein in Health and Disease
| Author | : Waliza Ansar |
| Publisher | : Springer |
| Total Pages | : 324 |
| Release | : 2016-03-23 |
| Genre | : Medical |
| ISBN | : 8132226801 |
This book offers a comprehensive study of C-reactive protein (CRP) belonging to the pentraxin family, including a brief history of CRP, its structure, synthesis and evolution. Focusing on the emerging role of CRP and its clinical application in the field of disease biology, it details the pathophysiological role of CRP in a host of diseases such as cardiovascular disease, diabetes, cancers, rheumatoid arthritis and infectious diseases and others. It also discusses the role of innate immunity and acute phase response (APR) and their key mediators in the host body in response to tissue injury, infection, trauma or surgery, immunological disorders or neoplastic growth. CRP’s significance in inflammation is highlighted, and its importance as a clinical marker in cardiovascular disease, its functional significance in Leishmania and Plasmodium infections, its association with the development of insulin resistance in type 2 diabetes mellitus, and its role in cancer are discussed in detail. The book also includes clinical data studies and presents the latest research advances to further readers’ understanding of CRP.
Coronary Microvascular Dysfunction
| Author | : Filippo Crea |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 263 |
| Release | : 2013-08-15 |
| Genre | : Medical |
| ISBN | : 8847053676 |
In the past two decades a number of studies have shown that abnormalities in the function and structure of coronary microcirculation can be detected in several cardiovascular diseases. On the basis of the clinical setting in which it occurs, coronary microvascular dysfunction (CMD) can be classified into four types: CMD in the absence of any other cardiac disease; CMD in myocardial diseases; CMD in obstructive epicardial coronary artery disease; and iatrogenic CMD. In some instances CMD represents an epiphenomenon, whereas in others it represents an important marker of risk or may contribute to the pathogenesis of myocardial ischemia, thus becoming a possible therapeutic target. This book provides an update on coronary physiology and a systematic assessment of microvascular abnormalities in cardiovascular diseases, in the hope that it will assist clinicians in prevention, detection and management of CMD in their everyday activity.
