NK-Myeloid Cell Interactions in the Tumor Microenvironment: Implications for Cancer Immunotherapy
| Author | : Erik Wennerberg |
| Publisher | : Frontiers Media SA |
| Total Pages | : 144 |
| Release | : 2021-09-08 |
| Genre | : Medical |
| ISBN | : 2889712710 |
Nk Myeloid Cell Interactions In The Tumor Microenvironment Implications For Cancer Immunotherapy
Download Nk Myeloid Cell Interactions In The Tumor Microenvironment Implications For Cancer Immunotherapy full books in PDF, epub, and Kindle. Read online free Nk Myeloid Cell Interactions In The Tumor Microenvironment Implications For Cancer Immunotherapy ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Natural Killer Cells
| Author | : Srinivas S. Somanchi |
| Publisher | : Humana Press |
| Total Pages | : 365 |
| Release | : 2016-05-13 |
| Genre | : Medical |
| ISBN | : 9781493936823 |
This volume contains collection of Natural Killer Cell methodologies relevant for both basic and translational research. These methodologies present new developments in the natural killer (NK) cell field, such as understanding the influence of NK cells metabolism on its function, identifying complexity of NK cell subsets through mass cytometry, and determining the emergence of memory NK cells in murine model of MCMV infection. Methods that study NK cell migration and cytotoxicity through endpoint analysis or live single cell imaging are also discussed. Chapters also describe methods pertaining to translational application of NK cells, such as ex vivo expansion of NK cells on K562 cell lines genetically modified to express either membrane bound IL-15 or membrane bound IL-21, large scale NK cell culture, current techniques for engineering NK cells to express chimeric antigen receptors or chemokine receptors using retroviral vectors, electroporation of mRNA, and the natural phenomenon of trogocytosis. Written in the highly successful Methods in Molecular Biology series format, these chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting edge and thorough, Natural Killer Cells: Methods and Protocols is a valuable resource for researchers who not only want to understand mechanisms that govern NK cell behavior and diversity, but also for those who want to understand how to systematically evaluate NK cells for adoptive immunotherapy applications.
Tertiary Lymphoid Structures
| Author | : Marie-Caroline Dieu-Nosjean |
| Publisher | : Humana Press |
| Total Pages | : 289 |
| Release | : 2018-09-05 |
| Genre | : Medical |
| ISBN | : 9781493987085 |
This volume explores the various methods used to study tertiary lymphoid structures (TLS) in pathological situations. Pre-clinical models are also discussed in detail to show how TLS structure, development, and maintenance can be targeted and studied in vivo. The chapters in this book cover topics such as humans and mice; strategies to quantify TLS in order to use it in stained tissue sections; classifying a gene signature form fixed and paraffin-embedded tissues; and development of murine inflammatory models to help look at TLS in the context of infection or malignancy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and thorough, Tertiary Lymphoid Structures: Methods and Protocols is a valuable resource that increases the reader’s knowledge on immune functions and how they will pave the way to future therapeutic applications.
The Link Between Inflammation and Cancer
| Author | : Angus G. Dalgleish |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 260 |
| Release | : 2006-03-05 |
| Genre | : Medical |
| ISBN | : 0387262830 |
A link between inflammation and cancer has been established many years ago, yet it is only recently that the potential significance of this connection has become apparent. Although several examples of chronic inflammatory conditions, often induced by persistent irritation and/or infection, developing into cancer have been known for some time, there has been a notable resistance to contemplate the possibility that this association may apply in a causative way to other cancers. Examples for such progression from chronic inflammation to cancer are colon carcinoma developing with increased frequency in patients with ulcerative colitis, and the increased incidence of bladder cancer in patients suffering from chronic Schistosoma infection. Inflammation and cancer have been recognized to be linked in another context for many years, i.e., with regards to pathologies resembling chronic lacerations or 'wounds that do not heal.' More recently, the immunology of wound healing has given us clues as to the mechanistic link between inflammation and cancer, in as much as wounds and chronic inflammation turn off local cell-mediated immune responses and switch on growth factor release as well the growth of new blood vessels - angiogenesis. Both of these are features of most types of tumours, which suggest that tumours may require an immunologically shielded milieu and a growth factor-rich environment.
Successes and Challenges of NK Immunotherapy
| Author | : Benjamin Bonavida |
| Publisher | : Academic Press |
| Total Pages | : 540 |
| Release | : 2021-06-23 |
| Genre | : Science |
| ISBN | : 0128243961 |
Successes and Challenges of NK Immunotherapy: Increasing Anti-tumor Efficacy describes the unique therapeutic applications of NK cells to fight cancers and eliminate the bulk and subset of cancer stem cells responsible for metastasis, relapse and recurrences. The book provides information on the development, engineering, mechanisms of action, response to various preclinical models, and applications in various clinical trials. Sections cover the development of highly engineered cytotoxic NK cells, their mechanisms of action, preclinical and clinical applications, the development and application of CAR-NK cells, and new NK-drug conjugates, also emphasizing that activated NK cells can target and kill highly resistant cancer stem cells. Written by the leading experts on NK immunotherapy worldwide, this is a valuable resource for researchers, clinicians and members of the biomedical field who are interested in understanding novel and efficient therapies to fight cancers. - Discusses the unique developmental applications of NK immunotherapy against cancers, which differs greatly from other types of immunotherapies - Provides up-to-date and highly relevant information through chapters written by the leading researchers in the field - Presents a significant number of schematic diagrams for easy understanding and reproducibility
The Heterogeneity of Cancer Metabolism
| Author | : Anne Le |
| Publisher | : Springer |
| Total Pages | : 186 |
| Release | : 2018-06-26 |
| Genre | : Medical |
| ISBN | : 331977736X |
Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.
PET/CT in Melanoma
| Author | : Michael S. Hofman |
| Publisher | : Springer |
| Total Pages | : 73 |
| Release | : 2017-07-31 |
| Genre | : Medical |
| ISBN | : 3319547410 |
This pocket book provides up-to-date guidance on the use of PET/CT in patients with melanoma, which is of rapidly growing importance due to the emergence of immunotherapy. The role of PET/CT in diagnostic workup, staging, treatment selection, prognostication, and follow-up is clearly explained. Imaging features are described and illustrated with the aid of a series of teaching cases, and attention is drawn to normal variants, artifacts, and pitfalls. Readers will also find explanation of the relation of the clinical and pathological background to imaging and the value of PET/CT compared with conventional radiological imaging. The book is published within the Springer series Clinicians’ Guides to Radionuclide Hybrid Imaging (compiled under the auspices of the British Nuclear Medicine Society) and will be an excellent asset for referring clinicians, nuclear medicine/radiology physicians, radiographers/technologists, and nurses who routinely work in nuclear medicine and participate in multidisciplinary meetings.
Tumor Microenvironment
| Author | : Alexander Birbrair |
| Publisher | : Springer Nature |
| Total Pages | : 153 |
| Release | : 2020-02-08 |
| Genre | : Science |
| ISBN | : 3030357236 |
Revealing essential roles of the tumor microenvironment in cancer progression, this book focuses on the role of hematopoietic components of the tumor microenvironment. Further, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development. Topics include neutrophils, basophils, T helper cells, cytotoxic lymphocytes, fibrocytes, and myeloid-derived suppressor cells, and more. Taken alongside its companion volumes, these books update us on what we know about various aspects of the tumor microenvironment as well as future directions. Tumor Microenvironment: Hematopoietic Cells – Part A is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.
Rediscovering Cancer: From Mechanism to Therapy
| Author | : Sayali Mukherjee |
| Publisher | : CRC Press |
| Total Pages | : 599 |
| Release | : 2018-09-04 |
| Genre | : Medical |
| ISBN | : 1351166549 |
This volume presents a snapshot of some of the most important ongoing research in cancer. With cancer as the second leading cause of death worldwide, extensive research is going on globally to decipher the molecular mechanism underlying cancer that will help in finding better targets for drug therapy. The book brings together new research on molecular mechanism and cancer therapeutics in one place. With chapters from experts in their respective fields, chapters cover molecular mechanisms, etiology, prognosis, detection, and treatment of cancer. Emphasis has been given to the intricate mechanism behind the deregulation of cell division, disruption of cell cycle check points, mutation in oncogenes and tumor suppressor genes, apoptosis, and erratic cell signaling. The book discusses in detail topics such as angiogenesis and tumor microenvironment, which are increasingly receiving attention, especially in the field of neoplastic vascularization and metastasis. The book also includes chapters detailing the current understanding and the future perspective of cancer stem cells.
Modulation of Human Immune Parameters by Anticancer Therapies
| Author | : Ulrich Sack |
| Publisher | : Frontiers Media SA |
| Total Pages | : 169 |
| Release | : 2021-01-18 |
| Genre | : Medical |
| ISBN | : 288966399X |
