For young John Degraffenreidt, a sleepless night is no reason to fret when tossing and turning in bed brings a bright red crocodile named Crosley out from under his bed. Night Buddies like Crosley promise an evening of adventure to any not-tired-yet kid-and tonight is no different! Out of bed, and into the city, John embarks on a one-of-a-kind program with his crocodile pal. It seems like Cros is a one-of-a-kind individual-that is, until red crocs start popping up all over the city, creating confusion, committing crimes, and causing Crosley to go bananas at the sight of them.

When pineapple cheesecakes start disappearing from the world's only Pineapple Cheesecake Factory across town, Crosley, a zany red crocodile, enlists the help of young John Degraffenreidt to straighten things out. In this adventure-fantasy, the unlikely pair sneaks out of John's house by becoming invisible, thanks to the I-ain't-here doodad Crosley uses from the bunch of whatchamacallits hanging on his belt. On the way to the subway they get better acquainted, and John finds out the wacky reason Crosley is red, and also what happens if he gets any water on him. They get on the Night Folks Limited train and ride all the way to the Cheesecake Factory where they meet the giant manager, Big Foot Mae. There is danger ahead, but the Night Buddies must stay with their "e;Program"e; (the Night Buddies word for Adventure) if the world's supply of pineapple cheesecakes counts for anything. And it surely does, especially to Crosley who is totally goofy about the things and never seems to get his fill.