Physico-Chemical and Computational Approaches to Drug Discovery

Physico-Chemical and Computational Approaches to Drug Discovery
Author: Javier Luque
Publisher: Royal Society of Chemistry
Total Pages: 443
Release: 2012-03-31
Genre: Medical
ISBN: 1849735379

Molecular modeling and simulation play a central role in academic and industrial research focused on physico-chemical properties and processes. The efforts carried out in this field have crystallized in a variety of models, simulation methods, and computational techniques that are examining the relationship between the structure, dynamics and functional role of biomolecules and their interactions. In particular, there has been a huge advance in the understanding of the molecular determinants that mediate the interaction between small compounds acting as ligands and their macromolecular targets. This book provides an updated description of the advances experienced in recent years in the field of molecular modeling and simulation of biomolecular recognition, with particular emphasis towards the development of efficient strategies in structure-based drug design.

The Navier-Stokes Equations

The Navier-Stokes Equations
Author: Rodolfo Salvi
Publisher: CRC Press
Total Pages: 337
Release: 2001-09-27
Genre: Mathematics
ISBN: 0824744896

"Contains proceedings of Varenna 2000, the international conference on theory and numerical methods of the navier-Stokes equations, held in Villa Monastero in Varenna, Lecco, Italy, surveying a wide range of topics in fluid mechanics, including compressible, incompressible, and non-newtonian fluids, the free boundary problem, and hydrodynamic potential theory."

Road and Off-Road Vehicle System Dynamics Handbook

Road and Off-Road Vehicle System Dynamics Handbook
Author: Gianpiero Mastinu
Publisher: CRC Press
Total Pages: 1710
Release: 2014-01-06
Genre: Science
ISBN: 0849333229

Featuring contributions from leading experts, the Road and Off-Road Vehicle System Dynamics Handbook provides comprehensive, authoritative coverage of all the major issues involved in road vehicle dynamic behavior. While the focus is on automobiles, this book also highlights motorcycles, heavy commercial vehicles, and off-road vehicles. The authors of the individual chapters, both from automotive industry and universities, address basic issues, but also include references to significant papers for further reading. Thus the handbook is devoted both to the beginner, wishing to acquire basic knowledge on a specific topic, and to the experienced engineer or scientist, wishing to have up-to-date information on a particular subject. It can also be used as a textbook for master courses at universities. The handbook begins with a short history of road and off-road vehicle dynamics followed by detailed, state-of-the-art chapters on modeling, analysis and optimization in vehicle system dynamics, vehicle concepts and aerodynamics, pneumatic tires and contact wheel-road/off-road, modeling vehicle subsystems, vehicle dynamics and active safety, man-vehicle interaction, intelligent vehicle systems, and road accident reconstruction and passive safety. Provides extensive coverage of modeling, simulation, and analysis techniques Surveys all vehicle subsystems from a vehicle dynamics point of view Focuses on pneumatic tires and contact wheel-road/off-road Discusses intelligent vehicle systems technologies and active safety Considers safety factors and accident reconstruction procedures Includes chapters written by leading experts from all over the world This text provides an applicable source of information for all people interested in a deeper understanding of road vehicle dynamics and related problems.

Progress in the Analysis and Design of Marine Structures

Progress in the Analysis and Design of Marine Structures
Author: Carlos Guedes Soares
Publisher: CRC Press
Total Pages: 952
Release: 2017-04-28
Genre: Technology & Engineering
ISBN: 1351653415

Progress in the Analysis and Design of Marine Structures collects the contributions presented at MARSTRUCT 2017, the 6th International Conference on Marine Structures (Lisbon, Portugal, 8-10 May 2017). The MARSTRUCT series of Conferences started in Glasgow, UK in 2007, the second event of the series having taken place in Lisbon, Portugal in March 2009, the third in Hamburg, Germany in March 2011, the fourth in Espoo, Finland in March 2013, and the fifth in Southampton, UK in March 2015. This Conference series deals with Ship and Offshore Structures, addressing topics in the areas of: - Methods and Tools for Loads and Load Effects - Methods and Tools for Strength Assessment - Experimental Analysis of Structures - Materials and Fabrication of Structures - Methods and Tools for Structural Design and Optimisation, and - Structural Reliability, Safety and Environmental Protection Progress in the Analysis and Design of Marine Structures is essential reading for academics, engineers and all professionals involved in the design of marine and offshore structures.