Ocular Neuroprotection

Ocular Neuroprotection
Author: Leonard Levin
Publisher: CRC Press
Total Pages: 336
Release: 2003-07
Genre: Medical
ISBN: 0824756134

Ocular neuroprotection is aimed at protecting the death of photoreceptors, retinal ganglion, or other important neurons in cases of disease or trauma. Levin (ophthalmology and neurology, U. of Wisconsin at Madison, US) and Di Polo (pathology and cell biology, U. of Montreal, Canada) present 18 chapt.

Advances in Animal Health, Medicine and Production

Advances in Animal Health, Medicine and Production
Author: Antonio Freitas Duarte
Publisher: Springer Nature
Total Pages: 575
Release: 2020-11-21
Genre: Medical
ISBN: 3030619818

This book brings together in a review manner a comprehensive summary of high-quality research contributions from the different research teams and their collaborators, to celebrate the 25th anniversary of the Centre for Interdisciplinary Research in Animal Health (CIISA). The topics span from animal behaviour and welfare over biotechnology to clinical veterinary medicine. Thus, the book is of interest for researchers and students working in the diverse fields of veterinary medicine and science. The Centre for Interdisciplinary Research in Animal Health (CIISA), the Research Centre of the Faculty of Veterinary Medicine of the University of Lisbon, commemorated its 25th-year jubilee in 2018. Throughout its history, CIISA has been consolidating as the top-ranking Portuguese Animal and Veterinary Sciences research unit. More recently, CIISA has taken a leading role in the coordination of national and international research networks and consortiums. This conveyed a highly interdisciplinary nature to CIISA’s research, encompassing animal, veterinary and biomedical sciences. This multi- and interdisciplinary nature is reflected on the broad scientific background of the team.

Webvision

Webvision
Author: Helga Kolb
Publisher:
Total Pages:
Release: 2007
Genre:
ISBN:

Glaucoma: An Open-Window to Neurodegeneration and Neuroprotection

Glaucoma: An Open-Window to Neurodegeneration and Neuroprotection
Author: Carlo Nucci
Publisher: Newnes
Total Pages: 639
Release: 2008-11-05
Genre: Medical
ISBN: 0080932800

Glaucoma is one of the main causes of blindness throughout the world. It is characterized by death of the retinal ganglion cells, which is associated with loss of the axons making up the optic nerve. Recent studies have demonstrated support for the classification of glaucoma as a degenerative disease of the central nervous system (CNS), leading researchers to look at identifying neuroprotection strategies for the treatment of this disease, like those used for other degenerative diseases of the CNS. This book will provide an in-depth examination of the most recent findings regarding glaucoma, including risk factors, diagnosis, clinical monitoring, treatment, and above all, the need for treatment based on the concept of neuroprotection. A large part of the book is devoted to research related to this new approach to the treatment of glaucoma. Describes the most recent developments on neuroprotection of the optic nerve, including experimental models now used and clinical protocols Discusses new strategies for the prevention of neuronal injury in glaucoma patients Focuses on evidence-based risk factors, innovative diagnostic aspects and advanced medical/surgical treatment of glaucoma

The Science of Glaucoma Management

The Science of Glaucoma Management
Author: Kevin Gillmann
Publisher: Elsevier
Total Pages: 484
Release: 2023-05-18
Genre: Science
ISBN: 0323884431

The Science of Glaucoma Management: From Translational Research to Next-Generation Clinical Practice bridges the gap between laboratory research and clinicians by bringing the latest promising research directly from researchers to clinicians long before they translate into clinical advances, and often before they are presented at conferences. Organized as a series of clinically relevant topics written by world-leading experts, this book summarizes the current state of laboratory and translational research and draws on the potential implications for day-to-day clinical practice. It offers new insights and mind-opening statements through contributions from some of the most respected glaucoma research groups. The book allows glaucoma specialists to explore novel ways to refine and rethink their practice based on the latest discoveries in basic sciences and breakthrough technologies, and to gain a better understanding on how their specialty is evolving and how research may shape tomorrow’s practice. Presents a detailed report on the latest translational research and breakthroughs that may transform glaucoma practice Overviews the specialty from a scientific and clinical point-of-view Written by world-renowned clinicians and researchers in the field of glaucoma Includes insights, opinions and recommendations from some of the most prominent scientists and ophthalmologists Covers hot topics and the latest technologies in glaucoma, such as minimally invasive glaucoma surgery, telemedicine, gene therapy, neuroprotection and artificial intelligence

Glaucoma

Glaucoma
Author: Jihan Salame
Publisher:
Total Pages: 0
Release: 2018
Genre: Glaucoma
ISBN:

Glaucoma is a degenerative optic nerve disease that causes retinal ganglion cell loss and visual field loss. Current glaucoma therapy focuses on decreasing intraocular pressure with in the eye as it is one of the main risk factor, however in some patients, retinal ganglion cell death continues despite the intraocular pressure reduction. Treatment needs to shift from therapies that only control intraocular pressure to ones that focus on neuroprotection. Nerve Growth Factor (NGF) and its two receptors Trk A and p75 are expressed in the human eye and have shown a role in maintaining neuroprotection and normal eye health and vision. Growing evidence has shown a decline of NGF and its receptors in several ocular diseases, including glaucoma. This literature review examines the applicability of NGF as a treatment for glaucoma by acting as a protector of retinal ganglion cells and the optic nerve. This literature review shows NGF can exert neuroprotective effects on retinal ganglion cell (RGC) degeneration occuring in glaucoma subjects.

Mechanisms of the Glaucomas

Mechanisms of the Glaucomas
Author: Joyce Tombran-Tink
Publisher: Springer Science & Business Media
Total Pages: 747
Release: 2008-06-06
Genre: Medical
ISBN: 1597453730

The purpose of this important new book is to provide basic scientists working in the field of glaucoma with a current understanding of the clinical aspects of glaucoma. The authors comprehensively review the most current knowledge available in the field and provide a basis in which researchers can effectively study the glaucomas. The multidisciplinary book will be of great value as its contents will aid the reader in prevention of blindness from glaucoma.

The Glaucoma Book

The Glaucoma Book
Author: Paul N. Schacknow
Publisher: Springer Science & Business Media
Total Pages: 1019
Release: 2010-06-10
Genre: Medical
ISBN: 0387767002

Complete evidence-based medical and surgical management of glaucoma for both the general ophthalmologist in practice and residents The only book that covers the new generation of glaucoma procedures including trabectome, trabecular bypass and canaloplasty, by the experts who developed them Includes the latest laser treatments for glaucoma including micro diode and titanium saphire trabeculoplasty as well as laser from an external approach The most comprehensive coverage of the optic nerve and the importance of nerve fiber layer hemorrhage Provides an integrated approach to neovascular glaucoma merging treatment to the retina, with the use of new anti-VEGF drugs, tubes, and shunts to achieve the best outcome Integrates clinical science with basic science to outline the next steps in glaucoma therapy

Melatonin

Melatonin
Author: Venkatramanujan Srinivasan
Publisher: CRC Press
Total Pages: 576
Release: 2014-10-15
Genre: Medical
ISBN: 1482220091

There is growing interest in the field of melatonin research regarding its neurobiological mechanisms as well as its repercussions in clinical practice. Melatonin: Therapeutic Value and Neuroprotection explores melatonin’s neuroprotective effects and discusses the therapeutic potential of melatonin and melatonin agonists in treating neurodegenerative diseases and other ailments. Topics include: The basic aspects of melatonin’s physiology, including its production, bioavailability, and metabolism The functional importance of melatonin receptors and their role in mediating the therapeutic effectiveness of melatonin in cancer Melatonin’s effect on the regulation of blood pressure, sleep, and circadian rhythms The cardioprotective role of melatonin The neuroprotective role in glaucoma, Alzheimer’s disease, Parkinson’s disease, and neurodegenerative diseases Use as a therapeutic agent for treating epilepsy and degenerative discs Treatment for obesity, diabetes mellitus, and other metabolic disorders Protective role in peri-natal hypoxic-ischemia The contributors also examine the discovery of a number of melatonergic agonists, their potential role as antioxidants, and their therapeutic applications in treating glaucoma, Parkinson’s disease, Alzheimer’s disease, primary insomnia, and psychiatric disorders. Opening new vistas in our understanding of etiology, pharmacotherapy, and treatment, the book is a significant milestone in our knowledge about advances in melatonin’s physiology and its therapeutic application in a number of disorders.

Sigma Receptors: Their Role in Disease and as Therapeutic Targets

Sigma Receptors: Their Role in Disease and as Therapeutic Targets
Author: Sylvia B. Smith
Publisher: Springer
Total Pages: 311
Release: 2017-03-16
Genre: Medical
ISBN: 3319501747

Originally confused with opioid receptors and then orphan receptors with no biological function, Sigma Receptors are now recognized as relevant to many degenerative diseases with remarkable potential as therapeutic targets. In this text, new information about the structure of sigma 1 receptor, its binding sites are provided as well as its expression in many cell types. It’s putative role in degenerative neuronal diseases including amyotrophic lateral sclerosis, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, pain, drug addiction and locomotor activity. Their roles in possible treatments for blinding retinal diseases emphasize the tremendous far-reaching potential for ligands for these receptors. Exciting breakthroughs in this dynamic field in the last decade are reported herein, which will guide future investigators in determining the full potential of this unique, yet abundantly expressed protein.